STRINGSTRING
LEF1 LEF1 DDX5 DDX5 SMPD3 SMPD3 BMPR1B BMPR1B ETV2 ETV2 USP15 USP15 PDCD4 PDCD4 SLC39A5 SLC39A5 DLX3 DLX3 COMP COMP FKBP8 FKBP8 ACVRL1 ACVRL1 MAPK3 MAPK3 BMP6 BMP6 HIVEP1 HIVEP1 ENSCSAP00000003769 ENSCSAP00000003769 TMPRSS6 TMPRSS6 HFE HFE FAM83G FAM83G GDF7 GDF7 NODAL NODAL SCX SCX CHRDL1 CHRDL1 BMPR1A BMPR1A GDF3 GDF3 GDF2 GDF2 GDF5 GDF5 BMPR2 BMPR2 EXT1 EXT1 TGFB3 TGFB3 SLC33A1 SLC33A1 GDF6 GDF6 RUNX2 RUNX2 BMP15 BMP15 WNT5A WNT5A DLX5 DLX5 EGR1 EGR1 SMAD6 SMAD6 BMP5 BMP5 SMAD3 SMAD3 SMAD5 SMAD5 SOSTDC1 SOSTDC1 BMP2 BMP2 CHRD CHRD ENG ENG USP9X USP9X ACVR2B ACVR2B ATF2 ATF2 ABL1 ABL1 BMP4 BMP4 BMPER BMPER BMP10 BMP10 SFRP1 SFRP1 RGMB RGMB BMP7 BMP7 ZNF831 ZNF831 CCDC142 CCDC142 TGFB2 TGFB2 ACVR1 ACVR1 ACVR2A ACVR2A MSX1 MSX1 LEFTY1 LEFTY1 LEFTY2 LEFTY2 FST FST RGMA RGMA TWSG1 TWSG1 SMURF1 SMURF1 DSG4 DSG4 SMAD9 SMAD9 SPART SPART SMAD7 SMAD7 SMAD4 SMAD4 USP9Y USP9Y TGFB1 TGFB1 SOST SOST MEGF8 MEGF8 SMAD1 SMAD1 SFRP2 SFRP2 HJV HJV NOTCH2 NOTCH2 ZNF8 ZNF8 TGFBR3 TGFBR3 ENSCSAP00000016878 ENSCSAP00000016878 ENSCSAP00000016884 ENSCSAP00000016884 ENSCSAP00000016885 ENSCSAP00000016885 HES5 HES5 NOG NOG TMEM100 TMEM100 ZCCHC12 ZCCHC12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEF1Lymphoid enhancer binding factor 1. (331 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (536 aa)
ETV2ETS variant 2. (375 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
PDCD4Programmed cell death 4. (469 aa)
SLC39A5Solute carrier family 39 member 5. (540 aa)
DLX3Distal-less homeobox 3. (287 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
BMP6Bone morphogenetic protein 6. (433 aa)
HIVEP1Uncharacterized protein. (2175 aa)
ENSCSAP00000003769Uncharacterized protein. (473 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (800 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (300 aa)
FAM83GFamily with sequence similarity 83 member G. (673 aa)
GDF7Growth differentiation factor 7. (447 aa)
NODALNodal growth differentiation factor. (347 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
CHRDL1Chordin like 1. (458 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GDF3Growth differentiation factor 3. (364 aa)
GDF2Growth differentiation factor 2. (429 aa)
GDF5Growth differentiation factor 5. (499 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (420 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SLC33A1Solute carrier family 33 member 1. (550 aa)
GDF6Growth differentiation factor 6. (455 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (450 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
DLX5Distal-less homeobox 5. (289 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (956 aa)
ENGEndoglin. (658 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (354 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ABL1Tyrosine-protein kinase. (1130 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
BMPERBMP binding endothelial regulator. (685 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (478 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ZNF831Zinc finger protein 831. (1676 aa)
CCDC142Coiled-coil domain containing 142. (750 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
MSX1Msh homeobox 1. (303 aa)
LEFTY1Left-right determination factor. (366 aa)
LEFTY2Left-right determination factor. (366 aa)
FSTFollistatin. (344 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (450 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
SMURF1E3 ubiquitin-protein ligase. (728 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1052 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
SPARTSpartin. (666 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
USP9YUbiquitin specific peptidase 9 Y-linked; Belongs to the peptidase C19 family. (2237 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SOSTSclerostin. (213 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
NOTCH2Notch receptor 2. (2471 aa)
ZNF8Zinc finger protein 8. (575 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
ENSCSAP00000016878TGF_BETA_2 domain-containing protein. (354 aa)
ENSCSAP00000016884TGF_BETA_2 domain-containing protein. (292 aa)
ENSCSAP00000016885TGFb_propeptide domain-containing protein. (144 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TMEM100Transmembrane protein 100. (134 aa)
ZCCHC12Zinc finger CCHC-type containing 12. (404 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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