STRINGSTRING
NCOA3 NCOA3 CYP27B1 CYP27B1 IKBKB IKBKB NKX6-3 NKX6-3 SFRP4 SFRP4 BMP7 BMP7 ENSCSAP00000011565 ENSCSAP00000011565 ADD1 ADD1 NOTCH1 NOTCH1 REG3A REG3A ATOH8 ATOH8 HEY2 HEY2 PROM1 PROM1 FST FST FGF10 FGF10 IL1B IL1B AHI1 AHI1 PROC PROC CTNNB1 CTNNB1 GDNF GDNF PRLR PRLR MESP1 MESP1 ROCK1 ROCK1 SERPINE1 SERPINE1 ETV4 ETV4 CEACAM1 CEACAM1 YAP1 YAP1 STAT5B STAT5B KRT36 KRT36 SULT2B1 SULT2B1 MED1 MED1 F11R F11R NFE2L1 NFE2L1 TBX3 TBX3 MAFG MAFG PTCH2 PTCH2 MYCL MYCL KDF1 KDF1 ERRFI1 ERRFI1 AJAP1 AJAP1 TP73 TP73 HES5 HES5 SFN SFN TMEM100 TMEM100 ATOH1 ATOH1 SPRY1 SPRY1 ENSCSAP00000017686 ENSCSAP00000017686 FOXE3 FOXE3 ENSCSAP00000017880 ENSCSAP00000017880 S1PR3 S1PR3 SPRY2 SPRY2 COMMD5 COMMD5 ZBED2 ZBED2 CEBPB CEBPB S1PR2 S1PR2 ASCL1 ASCL1 FOXC1 FOXC1 CLDN5 CLDN5 SOX9 SOX9 NUMA1 NUMA1 SPRED3 SPRED3 ZFP36 ZFP36 WNT9B WNT9B BTG1 BTG1 IL20 IL20 CDH5 CDH5 FOXJ1 FOXJ1 PAX6 PAX6 PAX2 PAX2 VEZF1 VEZF1 ACVRL1 ACVRL1 WNT10B WNT10B PTCH1 PTCH1 VDR VDR MAFF MAFF EZH2 EZH2 KEAP1 KEAP1 BAD BAD SPRED1 SPRED1 FOXN1 FOXN1 ROCK2 ROCK2 BMP6 BMP6 KRAS KRAS ETV2 ETV2 OSR1 OSR1 MACROH2A2 MACROH2A2 NODAL NODAL APOLD1 APOLD1 CDKN1B CDKN1B RFX3 RFX3 TRIM16 TRIM16 VCL VCL TP63 TP63 ZDHHC21 ZDHHC21 ABCA12 ABCA12 CCND1 CCND1 NOTCH4 NOTCH4 LIF LIF CDKN2B CDKN2B FOXJ2 FOXJ2 GDF3 GDF3 SMO SMO AQP3 AQP3 GDF2 GDF2 KLF7 KLF7 PAX4 PAX4 TNFRSF1A TNFRSF1A ALOX15B ALOX15B CAV1 CAV1 NKX2-2 NKX2-2 XDH XDH WWTR1 WWTR1 OVOL2 OVOL2 ZEB1 ZEB1 DLL1 DLL1 GRHL2 GRHL2 STAT1 STAT1 ESRP1 ESRP1 FRZB FRZB ID1 ID1 ZFP36L1 ZFP36L1 SIX2 SIX2 MACROH2A1 MACROH2A1 GATA3 GATA3 BMP2 BMP2 PLCB1 PLCB1 JAG1 JAG1 SGPP1 SGPP1 SRSF6 SRSF6 CD109 CD109 MMP9 MMP9 SPRED2 SPRED2 BMP4 BMP4 KIAA1109 KIAA1109 FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCOA3Nuclear receptor coactivator. (1417 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
NKX6-3Homeobox domain-containing protein. (265 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ENSCSAP00000011565Uncharacterized protein. (57 aa)
ADD1Adducin 1. (631 aa)
NOTCH1Notch receptor 1. (2555 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
ATOH8Atonal bHLH transcription factor 8. (330 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
PROM1Prominin 1. (855 aa)
FSTFollistatin. (344 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
AHI1Abelson helper integration site 1. (1202 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa; Belongs to the peptidase S1 family. (547 aa)
CTNNB1Catenin beta 1. (781 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
ETV4ETS variant 4. (415 aa)
CEACAM1Uncharacterized protein. (525 aa)
YAP1Yes associated protein 1. (508 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
KRT36Keratin 36; Belongs to the intermediate filament family. (421 aa)
SULT2B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (363 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
F11RF11 receptor. (323 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (772 aa)
TBX3T-box transcription factor 3. (723 aa)
MAFGMAF bZIP transcription factor G. (162 aa)
PTCH2Patched 2. (1203 aa)
MYCLMYCL proto-oncogene, bHLH transcription factor. (364 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
AJAP1Adherens junctions associated protein 1. (409 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (637 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
TMEM100Transmembrane protein 100. (134 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
ENSCSAP00000017686BHLH domain-containing protein. (358 aa)
FOXE3Forkhead box E3. (316 aa)
ENSCSAP00000017880Uncharacterized protein. (78 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
COMMD5COMM domain containing 5. (224 aa)
ZBED2Zinc finger BED-type containing 2. (218 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (239 aa)
FOXC1Forkhead box C1. (552 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
SOX9SRY-box transcription factor 9. (509 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2118 aa)
SPRED3Sprouty related EVH1 domain containing 3. (423 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
IL20Interleukin 20. (176 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
FOXJ1Forkhead box J1. (421 aa)
PAX6Paired box 6. (436 aa)
PAX2Paired box 2. (261 aa)
VEZF1Vascular endothelial zinc finger 1. (520 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PTCH1Patched 1. (1452 aa)
VDRVitamin D receptor. (434 aa)
MAFFMAF bZIP transcription factor F. (164 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
BADBCL2 associated agonist of cell death. (167 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
FOXN1Forkhead box N1. (648 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
BMP6Bone morphogenetic protein 6. (433 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ETV2ETS variant 2. (375 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
NODALNodal growth differentiation factor. (347 aa)
APOLD1Apolipoprotein L domain containing 1. (280 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
RFX3Regulatory factor X3. (753 aa)
TRIM16Uncharacterized protein. (557 aa)
VCLVinculin. (1134 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (500 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
ABCA12ATP binding cassette subfamily A member 12. (2571 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
NOTCH4Notch receptor 4. (1994 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (137 aa)
FOXJ2Forkhead box J2. (574 aa)
GDF3Growth differentiation factor 3. (364 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
GDF2Growth differentiation factor 2. (429 aa)
KLF7Kruppel like factor 7. (302 aa)
PAX4Paired box 4. (343 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (676 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NKX2-2NK2 homeobox 2. (273 aa)
XDHXanthine dehydrogenase. (1339 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1124 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
ESRP1Epithelial splicing regulatory protein 1. (663 aa)
FRZBFrizzled related protein. (325 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
SIX2SIX homeobox 2. (290 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (368 aa)
GATA3GATA binding protein 3. (443 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (441 aa)
SRSF6Serine and arginine rich splicing factor 6. (343 aa)
CD109CD109 molecule. (1201 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
SPRED2Sprouty related EVH1 domain containing 2. (415 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
KIAA1109KIAA1109. (4812 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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