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SLC25A46 SLC25A46 PLXNA2 PLXNA2 BMP7 BMP7 TTC21B TTC21B PROX1 PROX1 TBR1 TBR1 OGDH OGDH CTNNA2 CTNNA2 EN1 EN1 GLI2 GLI2 ENSCSAP00000012858 ENSCSAP00000012858 AHI1 AHI1 KLHL5 KLHL5 CTNNB1 CTNNB1 IGF1R IGF1R PHOX2B PHOX2B SEMA4C SEMA4C MYO16 MYO16 KLHL1 KLHL1 LOC103247300 LOC103247300 BCL2 BCL2 KNDC1 KNDC1 ENSCSAP00000014408 ENSCSAP00000014408 FZD4 FZD4 SMAD1 SMAD1 NAGLU NAGLU KAT2A KAT2A DIXDC1 DIXDC1 CD3E CD3E NCSTN NCSTN HOXB1 HOXB1 HOXB2 HOXB2 HOXB3 HOXB3 PTPN11 PTPN11 ATF5 ATF5 LHX5 LHX5 KDM2B KDM2B KCNC3 KCNC3 PTBP2 PTBP2 B4GALT2 B4GALT2 EPHB2 EPHB2 RERE RERE TRNP1 TRNP1 NOG NOG SSTR2 SSTR2 NHLH2 NHLH2 NEUROG3 NEUROG3 NEUROD1 NEUROD1 CDK5R2 CDK5R2 ASCL1 ASCL1 CEND1 CEND1 NEUROD2 NEUROD2 FOXC1 FOXC1 SSTR3 SSTR3 ENSCSAP00000019086 ENSCSAP00000019086 ABAT ABAT TTBK2 TTBK2 SCRIB SCRIB MTPN MTPN HOXA2 HOXA2 CRK CRK NRXN1 NRXN1 KIF14 KIF14 UQCRQ UQCRQ HSPA5 HSPA5 BMP5 BMP5 CRKL CRKL ATRN ATRN LRRC1 LRRC1 WHRN WHRN PTF1A PTF1A HERC1 HERC1 LPAR1 LPAR1 RORA RORA ALDH1A2 ALDH1A2 OPHN1 OPHN1 DLL1 DLL1 HNF1B HNF1B LHX1 LHX1 FAIM2 FAIM2 CLP1 CLP1 ARL13B ARL13B MDK MDK TTLL1 TTLL1 LDB1 LDB1 CBLN1 CBLN1 RPGRIP1L RPGRIP1L NAV2 NAV2 GSX2 GSX2 KCNC1 KCNC1 GLI1 GLI1 AARS1 AARS1 HNRNPD HNRNPD ENSCSAP00000000562 ENSCSAP00000000562 GRID2 GRID2 PHOX2A PHOX2A LEF1 LEF1 SEC24B SEC24B EGF EGF CEP290 CEP290 COQ8B COQ8B PTPRS PTPRS GDF10 GDF10 ENSCSAP00000006443 ENSCSAP00000006443 ENSCSAP00000006449 ENSCSAP00000006449 GNPAT GNPAT KLHL4 KLHL4 LMX1A LMX1A ATP7A ATP7A EPHB1 EPHB1 TP53 TP53 ATP1B2 ATP1B2 NFIB NFIB ENSCSAP00000005586 ENSCSAP00000005586 WNT7A WNT7A GART GART SMO SMO GATA2 GATA2 PSMG1 PSMG1 SPTBN2 SPTBN2 SERPINE2 SERPINE2 AGTPBP1 AGTPBP1 EGR2 EGR2 ZNF365 ZNF365 CNTN1 CNTN1 SEZ6 SEZ6 EZH2 EZH2 MECP2 MECP2 CDK5 CDK5 EN2 EN2 SHH SHH CDK5R1 CDK5R1 GBX2 GBX2 WNT1 WNT1 SEZ6L2 SEZ6L2 ATF2 ATF2 SCN5A SCN5A OTX1 OTX1 ABL1 ABL1 PDSS2 PDSS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC25A46Solute carrier family 25 member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)
PLXNA2Plexin A2. (1909 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TTC21BTetratricopeptide repeat domain 21B. (1316 aa)
PROX1Prospero homeobox 1. (737 aa)
TBR1T-box brain transcription factor 1. (682 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
CTNNA2Uncharacterized protein. (537 aa)
EN1Homeobox protein engrailed-like. (395 aa)
GLI2GLI family zinc finger 2. (1554 aa)
ENSCSAP00000012858START domain-containing protein. (1078 aa)
AHI1Abelson helper integration site 1. (1202 aa)
KLHL5Kelch like family member 5. (709 aa)
CTNNB1Catenin beta 1. (781 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
MYO16Myosin XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1471 aa)
KLHL1Kelch like family member 1. (582 aa)
LOC103247300Uncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
KNDC1Uncharacterized protein. (1124 aa)
ENSCSAP00000014408Rho-GAP domain-containing protein. (860 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (587 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
DIXDC1DIX domain containing 1. (683 aa)
CD3ECD3e molecule. (197 aa)
NCSTNNicastrin. (709 aa)
HOXB1Homeobox B1. (304 aa)
HOXB2Homeobox B2. (356 aa)
HOXB3Homeobox B3. (431 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ATF5Activating transcription factor 5. (291 aa)
LHX5LIM homeobox 5. (402 aa)
KDM2BLysine demethylase 2B. (1348 aa)
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (755 aa)
PTBP2Polypyrimidine tract binding protein 2. (531 aa)
B4GALT2Beta-1,4-galactosyltransferase 2. (353 aa)
EPHB2EPH receptor B2. (975 aa)
REREArginine-glutamic acid dipeptide repeats. (1566 aa)
TRNP1TMF1 regulated nuclear protein 1. (227 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
NEUROG3Neurogenin 3. (215 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (239 aa)
CEND1Cell cycle exit and neuronal differentiation 1. (152 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
FOXC1Forkhead box C1. (552 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa)
ENSCSAP00000019086Uncharacterized protein. (141 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
TTBK2Tau tubulin kinase 2. (1244 aa)
SCRIBScribble planar cell polarity protein. (1678 aa)
MTPNMyotrophin. (118 aa)
HOXA2Homeobox A2. (373 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
NRXN1Neurexin 1. (831 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1650 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ATRNAttractin. (1431 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
WHRNWhirlin. (907 aa)
PTF1APancreas associated transcription factor 1a. (329 aa)
HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4846 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
RORARAR related orphan receptor A. (490 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
OPHN1Oligophrenin 1. (792 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
HNF1BHNF1 homeobox B. (557 aa)
LHX1LIM homeobox 1. (406 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
ARL13BADP ribosylation factor like GTPase 13B. (428 aa)
MDKUncharacterized protein. (159 aa)
TTLL1Tubulin tyrosine ligase like 1. (423 aa)
LDB1LIM domain binding 1. (411 aa)
CBLN1Cerebellin 1 precursor. (193 aa)
RPGRIP1LRPGRIP1 like. (1263 aa)
NAV2Neuron navigator 2. (2284 aa)
GSX2GS homeobox 2. (304 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
GLI1GLI family zinc finger 1. (1106 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (355 aa)
ENSCSAP00000000562ANF_receptor domain-containing protein. (332 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (609 aa)
PHOX2APaired like homeobox 2A. (284 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1213 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
CEP290Centrosomal protein 290. (2513 aa)
COQ8BCoenzyme Q8B. (544 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1941 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
ENSCSAP00000006443Uncharacterized protein. (1287 aa)
ENSCSAP00000006449Uncharacterized protein. (1336 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (680 aa)
KLHL4Kelch like family member 4. (718 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (295 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
EPHB1EPH receptor B1. (984 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
ENSCSAP00000005586Uncharacterized protein. (163 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
GATA2GATA binding protein 2. (397 aa)
PSMG1Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2. (288 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2313 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
AGTPBP1ATP/GTP binding protein 1. (1193 aa)
EGR2Early growth response 2. (476 aa)
ZNF365Zinc finger protein 365. (407 aa)
CNTN1Contactin 1. (1018 aa)
SEZ6Seizure related 6 homolog. (995 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (479 aa)
CDK5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (224 aa)
EN2Homeobox protein engrailed-like. (335 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SEZ6L2Seizure related 6 homolog like 2. (923 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1881 aa)
OTX1Orthodenticle homeobox 1. (354 aa)
ABL1Tyrosine-protein kinase. (1130 aa)
PDSS2Decaprenyl diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (399 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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