STRINGSTRING
CAV1 CAV1 ANXA2 ANXA2 BDNF BDNF CLDN5 CLDN5 TICAM1 TICAM1 EPB41 EPB41 ENSCSAP00000016646 ENSCSAP00000016646 ZNF268 ZNF268 HIP1R HIP1R RFNG RFNG SPPL3 SPPL3 SPTA1 SPTA1 CSF3 CSF3 RAPGEF2 RAPGEF2 APOE APOE LFNG LFNG ARHGEF7 ARHGEF7 TERT TERT BLK BLK EPB41L5 EPB41L5 WNT3A WNT3A NVL NVL PPP2CB PPP2CB ADD1 ADD1 GCG GCG ADD2 ADD2 BMP4 BMP4 ABL1 ABL1 MMP9 MMP9 DACT1 DACT1 PPP2CA PPP2CA BMP2 BMP2 STING1 STING1 RIPK2 RIPK2 WNT5A WNT5A TRIB3 TRIB3 PSEN1 PSEN1 KRIT1 KRIT1 STK3 STK3 PRKN PRKN ENSCSAP00000008246 ENSCSAP00000008246 CTHRC1 CTHRC1 BAMBI BAMBI NRP1 NRP1 PLCL1 PLCL1 TAF1 TAF1 PKD1 PKD1 DERL1 DERL1 SPAG8 SPAG8 MARK3 MARK3 PLCL2 PLCL2 TAF1L TAF1L B2M B2M MAPRE3 MAPRE3 TIAM1 TIAM1 PLXND1 PLXND1 APP APP HSF1 HSF1 HIPK2 HIPK2 FLOT1 FLOT1 HFE HFE PIN1 PIN1 MFNG MFNG EPHB6 EPHB6 CAPRIN2 CAPRIN2 DTX3L DTX3L MEN1 MEN1 POLDIP2 POLDIP2 LRRK2 LRRK2 GSK3B GSK3B CDK5 CDK5 IDE IDE EP300 EP300 AKTIP AKTIP AMFR AMFR ENSCSAP00000001444 ENSCSAP00000001444 LRP1 LRP1 SPON1 SPON1 TRIM21 TRIM21
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ANXA2Annexin. (339 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (247 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (711 aa)
EPB41Erythrocyte membrane protein band 4.1. (667 aa)
ENSCSAP00000016646Peptidyl-prolyl cis-trans isomerase. (157 aa)
ZNF268Zinc finger protein 268. (947 aa)
HIP1RHuntingtin interacting protein 1 related. (1056 aa)
RFNGRFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (205 aa)
SPPL3Signal peptide peptidase like 3. (384 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2421 aa)
CSF3Colony stimulating factor 3. (207 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1685 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (236 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
BLKTyrosine-protein kinase. (505 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (699 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
NVLNuclear VCP like. (856 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ADD1Adducin 1. (631 aa)
GCGGlucagon. (180 aa)
ADD2Adducin 2. (726 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ABL1Tyrosine-protein kinase. (1130 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (798 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
STING1Transmembrane protein 173. (379 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (443 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TRIB3Tribbles pseudokinase 3. (358 aa)
PSEN1Presenilin 1. (467 aa)
KRIT1Uncharacterized protein. (736 aa)
STK3Serine/threonine kinase 3. (491 aa)
PRKNParkin RBR E3 ubiquitin protein ligase. (288 aa)
ENSCSAP00000008246Annexin. (284 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PLCL1Phosphoinositide phospholipase C. (997 aa)
TAF1Transcription initiation factor TFIID subunit. (1894 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (3853 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
SPAG8Sperm associated antigen 8. (402 aa)
MARK3Microtubule affinity regulating kinase 3. (529 aa)
PLCL2Phosphoinositide phospholipase C. (1127 aa)
TAF1LTATA-box binding protein associated factor 1 like. (1476 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
MAPRE3Microtubule associated protein RP/EB family member 3. (281 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1466 aa)
PLXND1Plexin D1. (1833 aa)
APPAmyloid beta precursor protein. (770 aa)
HSF1Heat shock transcription factor 1. (529 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (379 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (300 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (321 aa)
EPHB6EPH receptor B6. (1018 aa)
CAPRIN2Caprin family member 2. (1070 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (739 aa)
MEN1Menin 1. (610 aa)
POLDIP2DNA polymerase delta interacting protein 2. (408 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
CDK5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (224 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (978 aa)
EP300E1A binding protein p300. (2416 aa)
AKTIPAKT interacting protein. (292 aa)
AMFRAutocrine motility factor receptor. (643 aa)
ENSCSAP00000001444HMG box domain-containing protein. (377 aa)
LRP1LDL receptor related protein 1. (4544 aa)
SPON1Spondin 1. (807 aa)
TRIM21Tripartite motif containing 21. (475 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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