STRINGSTRING
ST18 ST18 POLA2 POLA2 H2BC5 H2BC5 MCM5 MCM5 MACROH2A2 MACROH2A2 PRM2 PRM2 TNP2 TNP2 MCM2 MCM2 POLD4 POLD4 RUVBL1 RUVBL1 GLYR1 GLYR1 TNP1 TNP1 KAT6B KAT6B XRCC5 XRCC5 H1-8 H1-8 ATF6B ATF6B CENPA CENPA ENSCSAP00000005631 ENSCSAP00000005631 ENSCSAP00000005636 ENSCSAP00000005636 H2BW2 H2BW2 BRF1 BRF1 NKX2-5 NKX2-5 NPM1 NPM1 DONSON DONSON POT1 POT1 ENSCSAP00000006521 ENSCSAP00000006521 GINS1 GINS1 CTC1 CTC1 ING3 ING3 ENSCSAP00000007253 ENSCSAP00000007253 NFYA NFYA TEAD4 TEAD4 EPC1 EPC1 ENSCSAP00000007796 ENSCSAP00000007796 RAD52 RAD52 CDC45 CDC45 TBP TBP KDM5A KDM5A LOC103232061 LOC103232061 FOS FOS WDR18 WDR18 ACTL6A ACTL6A MCM3 MCM3 RPA3 RPA3 GATA1 GATA1 BRD8 BRD8 MACROH2A1 MACROH2A1 MAX MAX PRIM2 PRIM2 TERF1 TERF1 ENSCSAP00000009816 ENSCSAP00000009816 EYA1 EYA1 POLR2H POLR2H RPA1 RPA1 TOP1 TOP1 ESR1 ESR1 MYOG MYOG HOXA11 HOXA11 POLA1 POLA1 NFE2L2 NFE2L2 HOXD11 HOXD11 ENSCSAP00000010702 ENSCSAP00000010702 SLF1 SLF1 SP3 SP3 MCM4 MCM4 PRKDC PRKDC KAT6A KAT6A GINS4 GINS4 POLD2 POLD2 H2AZ2 H2AZ2 TINF2 TINF2 MRGBP MRGBP EPC2 EPC2 MCM6 MCM6 PARP1 PARP1 CTNNB1 CTNNB1 ENSCSAP00000013063 ENSCSAP00000013063 SHPRH SHPRH ORC3 ORC3 TERT TERT TRRAP TRRAP GTF2F2 GTF2F2 MCM7 MCM7 ZNHIT1 ZNHIT1 ACTR6 ACTR6 ENSCSAP00000014778 ENSCSAP00000014778 GINS2 GINS2 JUP JUP NFYB NFYB SPHK2 SPHK2 RUVBL2 RUVBL2 TBX5 TBX5 POLD1 POLD1 GTF2H3 GTF2H3 EP400 EP400 ENSCSAP00000016160 ENSCSAP00000016160 VPS72 VPS72 GTF2B GTF2B DMAP1 DMAP1 MEAF6 MEAF6 RPA2 RPA2 HP1BP3 HP1BP3 ZBTB17 ZBTB17 H2AX H2AX LOC103232850 LOC103232850 LOC103232850-2 LOC103232850-2 ENSCSAP00000017607 ENSCSAP00000017607 MORF4L2 MORF4L2 LOC103229948 LOC103229948 H2BU1 H2BU1 H2AW H2AW H2BC18 H2BC18 H2BC21 H2BC21 H2AC20 H2AC20 H2AC21 H2AC21 H2AP H2AP LOC103247785 LOC103247785 LOC103247786 LOC103247786 ENSCSAP00000017862 ENSCSAP00000017862 LOC103232262 LOC103232262 ENSCSAP00000017985 ENSCSAP00000017985 ENSCSAP00000017986 ENSCSAP00000017986 JUND JUND SOX12 SOX12 H1-10 H1-10 PRM3 PRM3 LOC103215048 LOC103215048 HIST1H2BO HIST1H2BO H3C11 H3C11 H1-5 H1-5 H2BC15 H2BC15 HIST1H2AL HIST1H2AL H2BC14 H2BC14 H2AC14 H2AC14 H2BC13 H2BC13 LOC103221972 LOC103221972 H2BC11 H2BC11 LOC103221946 LOC103221946 H1-3 H1-3 H2AC7 H2AC7 H1-4 H1-4 H2AC6 H2AC6 H2BC4 H2BC4 H1-6 H1-6 H1-2 H1-2 H2BC3 H2BC3 LOC103222003 LOC103222003 LOC103221946-2 LOC103221946-2 H1-1 H1-1 H2BC1 H2BC1 H2AC1 H2AC1 RAG2 RAG2 LOC103221971 LOC103221971 H2AJ H2AJ ENSCSAP00000018777 ENSCSAP00000018777 H1-0 H1-0 LOC103221619 LOC103221619 LOC103230365 LOC103230365 ACD ACD LEF1 LEF1 POLD3 POLD3 TERF2 TERF2 YEATS4 YEATS4 TAF10 TAF10 ENSCSAP00000000740 ENSCSAP00000000740 PLEKHA1 PLEKHA1 TERB1 TERB1 GINS3 GINS3 DDIT3 DDIT3 H3F3B H3F3B TEN1 TEN1 ENSCSAP00000001444 ENSCSAP00000001444 STN1 STN1 NFE2 NFE2 RAG1 RAG1 SP1 SP1 MBTD1 MBTD1 PAX2 PAX2 XRCC6 XRCC6 EP300 EP300 SRCAP SRCAP NUPR1 NUPR1 HHEX HHEX SUZ12 SUZ12 ENSCSAP00000003275 ENSCSAP00000003275 GTF2E1 GTF2E1 IRF4 IRF4 KDM1B KDM1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ST18ST18 C2H2C-type zinc finger transcription factor. (1047 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
PRM2Protamine 2. (103 aa)
TNP2Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. (141 aa)
MCM2DNA helicase; Belongs to the MCM family. (738 aa)
POLD4Uncharacterized protein. (107 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
GLYR1Glyoxylate reductase 1 homolog. (553 aa)
TNP1Transition protein 1. (55 aa)
KAT6BHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2070 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
H1-8H1 histone family member O oocyte specific. (346 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
CENPACentromere protein A. (138 aa)
ENSCSAP00000005631Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
ENSCSAP00000005636Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
H2BW2H2B histone family member M; Belongs to the histone H2B family. (175 aa)
BRF1BRF1 RNA polymerase III transcription initiation factor subunit. (677 aa)
NKX2-5NK2 homeobox 5. (324 aa)
NPM1Nucleophosmin 1. (294 aa)
DONSONDownstream neighbor of SON. (564 aa)
POT1Protection of telomeres 1. (634 aa)
ENSCSAP00000006521Uncharacterized protein. (266 aa)
GINS1GINS complex subunit 1. (285 aa)
CTC1CST telomere replication complex component 1. (1209 aa)
ING3Inhibitor of growth protein. (418 aa)
ENSCSAP00000007253Uncharacterized protein. (117 aa)
NFYANuclear transcription factor Y subunit alpha. (343 aa)
TEAD4TEA domain transcription factor 4. (361 aa)
EPC1Enhancer of polycomb homolog. (813 aa)
ENSCSAP00000007796H15 domain-containing protein. (342 aa)
RAD52RAD52 homolog, DNA repair protein. (411 aa)
CDC45Cell division cycle 45. (566 aa)
TBPTATA-box binding protein. (270 aa)
KDM5ALysine demethylase 5A. (1636 aa)
LOC103232061Histone domain-containing protein. (136 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
WDR18WD repeat domain 18. (432 aa)
ACTL6AActin like 6A; Belongs to the actin family. (429 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
RPA3Replication protein A3. (121 aa)
GATA1GATA binding protein 1. (414 aa)
BRD8Bromodomain containing 8. (969 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (368 aa)
MAXMYC associated factor X. (103 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (440 aa)
ENSCSAP00000009816Histone H3; Belongs to the histone H3 family. (136 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (586 aa)
POLR2HRNA polymerase II subunit H. (187 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
ESR1Estrogen receptor 1. (487 aa)
MYOGMyogenin. (249 aa)
HOXA11Homeobox A11. (310 aa)
POLA1DNA polymerase. (1465 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
HOXD11Homeobox D11. (338 aa)
ENSCSAP00000010702Nucleoplasmin domain-containing protein. (275 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
SP3Sp3 transcription factor. (781 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4131 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1726 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
TINF2TERF1 interacting nuclear factor 2. (424 aa)
MRGBPMRG domain binding protein. (204 aa)
EPC2Enhancer of polycomb homolog. (807 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
PARP1Poly(ADP-ribose) polymerase 1. (709 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSCSAP00000013063Uncharacterized protein. (278 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1683 aa)
ORC3Origin recognition complex subunit 3. (711 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3848 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
ZNHIT1Zinc finger HIT-type containing 1. (178 aa)
ACTR6Actin related protein 6; Belongs to the actin family. (428 aa)
ENSCSAP00000014778RPA_C domain-containing protein. (256 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
JUPJunction plakoglobin. (745 aa)
NFYBNuclear transcription factor Y subunit beta. (169 aa)
SPHK2Sphingosine kinase 2. (653 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
TBX5T-box transcription factor 5. (518 aa)
POLD1DNA polymerase. (1086 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
EP400E1A binding protein p400. (3161 aa)
ENSCSAP00000016160HSA domain-containing protein. (457 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (467 aa)
MEAF6MYST/Esa1 associated factor 6. (201 aa)
RPA2Replication protein A2. (270 aa)
HP1BP3Heterochromatin protein 1 binding protein 3. (456 aa)
ZBTB17BTB domain-containing protein. (244 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
LOC103232850Histone H2A; Belongs to the histone H2A family. (115 aa)
LOC103232850-2Histone H2A-Bbd type 2/3-like. (115 aa)
ENSCSAP00000017607Histone H2A; Belongs to the histone H2A family. (128 aa)
MORF4L2Mortality factor 4 like 2. (287 aa)
LOC103229948Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
H2APHuntingtin interacting protein M. (117 aa)
LOC103247785Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103247786Histone H3; Belongs to the histone H3 family. (136 aa)
ENSCSAP00000017862Histone domain-containing protein. (136 aa)
LOC103232262Histone H3; Belongs to the histone H3 family. (136 aa)
ENSCSAP00000017985Histone H2A; Belongs to the histone H2A family. (128 aa)
ENSCSAP00000017986Histone domain-containing protein. (136 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (348 aa)
SOX12Transcription factor SOX. (314 aa)
H1-10H1 histone family member X. (213 aa)
PRM3Protamine 3. (111 aa)
LOC103215048Histone domain-containing protein. (136 aa)
HIST1H2BOHistone H2B; Belongs to the histone H2B family. (126 aa)
H3C11Histone H3; Belongs to the histone H3 family. (136 aa)
H1-5Histone cluster 1 H1 family member b. (226 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST1H2ALHistone H2A; Belongs to the histone H2A family. (130 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC14Histone H2A; Belongs to the histone H2A family. (128 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103221972Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103221946Histone H3.1. (136 aa)
H1-3Histone cluster 1 H1 family member d. (221 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
H1-4Histone cluster 1 H1 family member e. (219 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
H2BC4Histone H2B; Belongs to the histone H2B family. (126 aa)
H1-6Histone cluster 1 H1 family member t. (208 aa)
H1-2Histone cluster 1 H1 family member c. (213 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103222003Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103221946-2Histone H3.1. (136 aa)
H1-1Histone cluster 1 H1 family member a. (215 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (131 aa)
RAG2Recombination activating 2. (527 aa)
LOC103221971Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
ENSCSAP00000018777Histone domain-containing protein. (136 aa)
H1-0H1 histone family member 0. (194 aa)
LOC103221619Histone domain-containing protein. (136 aa)
LOC103230365Histone H3; Belongs to the histone H3 family. (136 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (537 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
POLD3Uncharacterized protein. (466 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (500 aa)
YEATS4YEATS domain containing 4. (227 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
ENSCSAP00000000740Uncharacterized protein. (88 aa)
PLEKHA1Pleckstrin homology domain containing A1. (383 aa)
TERB1Telomere repeat binding bouquet formation protein 1. (727 aa)
GINS3GINS complex subunit 3. (216 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
TEN1Uncharacterized protein. (94 aa)
ENSCSAP00000001444HMG box domain-containing protein. (377 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
NFE2Nuclear factor, erythroid 2. (373 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (953 aa)
SP1Sp1 transcription factor. (786 aa)
MBTD1Mbt domain containing 1. (690 aa)
PAX2Paired box 2. (261 aa)
XRCC6X-ray repair cross complementing 6. (609 aa)
EP300E1A binding protein p300. (2416 aa)
SRCAPUncharacterized protein. (3169 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
HHEXHematopoietically expressed homeobox. (268 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
ENSCSAP00000003275Uncharacterized protein. (261 aa)
GTF2E1General transcription factor IIE subunit 1. (439 aa)
IRF4Interferon regulatory factor 4. (284 aa)
KDM1BLysine demethylase 1B. (822 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: medium (42%) [HD]