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| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | POLR2H | RNA polymerase II subunit H. (187 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (586 aa) |
| | ENSCSAP00000009816 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (440 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa) |
| | MAX | MYC associated factor X. (103 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (368 aa) |
| | BRD8 | Bromodomain containing 8. (969 aa) |
| | GATA1 | GATA binding protein 1. (414 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | IRF4 | Interferon regulatory factor 4. (284 aa) |
| | LOC103230365 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC103221619 | Histone domain-containing protein. (136 aa) |
| | H1-0 | H1 histone family member 0. (194 aa) |
| | ENSCSAP00000018777 | Histone domain-containing protein. (136 aa) |
| | H2AJ | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | LOC103221971 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | RAG2 | Recombination activating 2. (527 aa) |
| | H2AC1 | Histone H2A; Belongs to the histone H2A family. (131 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | H1-1 | Histone cluster 1 H1 family member a. (215 aa) |
| | LOC103221946-2 | Histone H3.1. (136 aa) |
| | LOC103222003 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H1-2 | Histone cluster 1 H1 family member c. (213 aa) |
| | H1-6 | Histone cluster 1 H1 family member t. (208 aa) |
| | H2BC4 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2AC6 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H1-4 | Histone cluster 1 H1 family member e. (219 aa) |
| | H2AC7 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H1-3 | Histone cluster 1 H1 family member d. (221 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (429 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H1-5 | Histone cluster 1 H1 family member b. (226 aa) |
| | H3C11 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | HIST1H2BO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103215048 | Histone domain-containing protein. (136 aa) |
| | PRM3 | Protamine 3. (111 aa) |
| | H1-10 | H1 histone family member X. (213 aa) |
| | SOX12 | Transcription factor SOX. (314 aa) |
| | JUND | JunD proto-oncogene, AP-1 transcription factor subunit. (348 aa) |
| | ENSCSAP00000017986 | Histone domain-containing protein. (136 aa) |
| | ENSCSAP00000017985 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | LOC103232262 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ENSCSAP00000017862 | Histone domain-containing protein. (136 aa) |
| | LOC103247786 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC103247785 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H2AP | Huntingtin interacting protein M. (117 aa) |
| | H2AC21 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | POLD1 | DNA polymerase. (1086 aa) |
| | GTF2H3 | General transcription factor IIH subunit 3. (309 aa) |
| | EP400 | E1A binding protein p400. (3161 aa) |
| | ENSCSAP00000016160 | HSA domain-containing protein. (457 aa) |
| | VPS72 | Vacuolar protein sorting 72 homolog. (364 aa) |
| | GTF2B | General transcription factor IIB. (316 aa) |
| | DMAP1 | DNA methyltransferase 1 associated protein 1. (467 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (201 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | HP1BP3 | Heterochromatin protein 1 binding protein 3. (456 aa) |
| | ZBTB17 | BTB domain-containing protein. (244 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | LOC103232850 | Histone H2A; Belongs to the histone H2A family. (115 aa) |
| | LOC103232850-2 | Histone H2A-Bbd type 2/3-like. (115 aa) |
| | ENSCSAP00000017607 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | MORF4L2 | Mortality factor 4 like 2. (287 aa) |
| | LOC103229948 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2AW | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H2BC18 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2AC20 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | TBX5 | T-box transcription factor 5. (518 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | SPHK2 | Sphingosine kinase 2. (653 aa) |
| | NFYB | Nuclear transcription factor Y subunit beta. (169 aa) |
| | JUP | Junction plakoglobin. (745 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | ENSCSAP00000014778 | RPA_C domain-containing protein. (256 aa) |
| | ACTR6 | Actin related protein 6; Belongs to the actin family. (428 aa) |
| | ZNHIT1 | Zinc finger HIT-type containing 1. (178 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | GTF2F2 | General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3848 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa) |
| | ORC3 | Origin recognition complex subunit 3. (711 aa) |
| | SHPRH | SNF2 histone linker PHD RING helicase. (1683 aa) |
| | ENSCSAP00000013063 | Uncharacterized protein. (278 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | PARP1 | Poly(ADP-ribose) polymerase 1. (709 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | EPC2 | Enhancer of polycomb homolog. (807 aa) |
| | MRGBP | MRG domain binding protein. (204 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (424 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | ENSCSAP00000005636 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | H2BW2 | H2B histone family member M; Belongs to the histone H2B family. (175 aa) |
| | BRF1 | BRF1 RNA polymerase III transcription initiation factor subunit. (677 aa) |
| | NKX2-5 | NK2 homeobox 5. (324 aa) |
| | NPM1 | Nucleophosmin 1. (294 aa) |
| | DONSON | Downstream neighbor of SON. (564 aa) |
| | POT1 | Protection of telomeres 1. (634 aa) |
| | ENSCSAP00000006521 | Uncharacterized protein. (266 aa) |
| | GINS1 | GINS complex subunit 1. (285 aa) |
| | CTC1 | CST telomere replication complex component 1. (1209 aa) |
| | ING3 | Inhibitor of growth protein. (418 aa) |
| | ENSCSAP00000007253 | Uncharacterized protein. (117 aa) |
| | NFYA | Nuclear transcription factor Y subunit alpha. (343 aa) |
| | TEAD4 | TEA domain transcription factor 4. (361 aa) |
| | EPC1 | Enhancer of polycomb homolog. (813 aa) |
| | ENSCSAP00000007796 | H15 domain-containing protein. (342 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (411 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | TBP | TATA-box binding protein. (270 aa) |
| | KDM5A | Lysine demethylase 5A. (1636 aa) |
| | LOC103232061 | Histone domain-containing protein. (136 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | WDR18 | WD repeat domain 18. (432 aa) |
| | KAT6A | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1726 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4131 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | ST18 | ST18 C2H2C-type zinc finger transcription factor. (1047 aa) |
| | SP3 | Sp3 transcription factor. (781 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | ENSCSAP00000010702 | Nucleoplasmin domain-containing protein. (275 aa) |
| | HOXD11 | Homeobox D11. (338 aa) |
| | NFE2L2 | Nuclear factor, erythroid 2 like 2. (606 aa) |
| | POLA1 | DNA polymerase. (1465 aa) |
| | HOXA11 | Homeobox A11. (310 aa) |
| | MYOG | Myogenin. (249 aa) |
| | ESR1 | Estrogen receptor 1. (487 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | MACROH2A2 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | PRM2 | Protamine 2. (103 aa) |
| | TNP2 | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. (141 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | GLYR1 | Glyoxylate reductase 1 homolog. (553 aa) |
| | TNP1 | Transition protein 1. (55 aa) |
| | KAT6B | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2070 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | H1-8 | H1 histone family member O oocyte specific. (346 aa) |
| | ATF6B | Activating transcription factor 6 beta. (711 aa) |
| | CENPA | Centromere protein A. (138 aa) |
| | ENSCSAP00000005631 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | LOC103221946 | Histone H3.1. (136 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103221972 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC13 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2AC14 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | HIST1H2AL | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (537 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (331 aa) |
| | POLD3 | Uncharacterized protein. (466 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (500 aa) |
| | YEATS4 | YEATS domain containing 4. (227 aa) |
| | TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa) |
| | ENSCSAP00000000740 | Uncharacterized protein. (88 aa) |
| | PLEKHA1 | Pleckstrin homology domain containing A1. (383 aa) |
| | TERB1 | Telomere repeat binding bouquet formation protein 1. (727 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa) |
| | H3F3B | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | TEN1 | Uncharacterized protein. (94 aa) |
| | ENSCSAP00000001444 | HMG box domain-containing protein. (377 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | NFE2 | Nuclear factor, erythroid 2. (373 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (953 aa) |
| | SP1 | Sp1 transcription factor. (786 aa) |
| | MBTD1 | Mbt domain containing 1. (690 aa) |
| | PAX2 | Paired box 2. (261 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (609 aa) |
| | EP300 | E1A binding protein p300. (2416 aa) |
| | SRCAP | Uncharacterized protein. (3169 aa) |
| | NUPR1 | Nuclear protein 1, transcriptional regulator. (82 aa) |
| | HHEX | Hematopoietically expressed homeobox. (268 aa) |
| | SUZ12 | SUZ12 polycomb repressive complex 2 subunit. (739 aa) |
| | ENSCSAP00000003275 | Uncharacterized protein. (261 aa) |
| | GTF2E1 | General transcription factor IIE subunit 1. (439 aa) |
| | KDM1B | Lysine demethylase 1B. (822 aa) |
