STRINGSTRING
POLD3 POLD3 SMPD1 SMPD1 USP47 USP47 TMEM161A TMEM161A MMP2 MMP2 N4BP1 N4BP1 DDB2 DDB2 EP300 EP300 RBX1 RBX1 ATF4 ATF4 DDB1 DDB1 ENSCSAP00000003275 ENSCSAP00000003275 EIF2AK4 EIF2AK4 BMF BMF SIRT1 SIRT1 INO80 INO80 RHBDD1 RHBDD1 MFAP4 MFAP4 ERCC4 ERCC4 CRIP1 CRIP1 XPC XPC OPN3 OPN3 ENSCSAP00000005812 ENSCSAP00000005812 BAK1 BAK1 CREBBP CREBBP NPM1 NPM1 TAF1L TAF1L OPN1SW OPN1SW MYC MYC MAPK13 MAPK13 ENSCSAP00000006521 ENSCSAP00000006521 CDKN1A CDKN1A RPL26 RPL26 AURKB AURKB XPA XPA TAF1 TAF1 RHNO1 RHNO1 ATR ATR TP53 TP53 NEDD4 NEDD4 DHX36 DHX36 POLH POLH STK11 STK11 TP53INP1 TP53INP1 OPN5 OPN5 PRKCD PRKCD PTGS2 PTGS2 EIF2S1 EIF2S1 PCNA PCNA TIMP1 TIMP1 ZBTB1 ZBTB1 ACTR5 ACTR5 HYAL2 HYAL2 HYAL1 HYAL1 HYAL3 HYAL3 ENSCSAP00000010702 ENSCSAP00000010702 MMP9 MMP9 AQP1 AQP1 POLK POLK C9orf116 C9orf116 NFATC4 NFATC4 PIK3R1 PIK3R1 CDC25A CDC25A PBK PBK SDE2 SDE2 PARP1 PARP1 PTPRK PTPRK METTL3 METTL3 ENSCSAP00000013063 ENSCSAP00000013063 CUL4A CUL4A IMPACT IMPACT CUL4B CUL4B FBXW7 FBXW7 ENSCSAP00000014836 ENSCSAP00000014836 MMP1 MMP1 MMP3 MMP3 ERCC1 ERCC1 USP28 USP28 BAX BAX RUVBL2 RUVBL2 CHEK1 CHEK1 TRIAP1 TRIAP1 POLD1 POLD1 KDM1A KDM1A CASP9 CASP9 NOC2L NOC2L H2AW H2AW ENSCSAP00000017875 ENSCSAP00000017875 ENSCSAP00000017976 ENSCSAP00000017976 MC1R MC1R NSMCE3 NSMCE3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLD3Uncharacterized protein. (466 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (626 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1355 aa)
TMEM161ATransmembrane protein 161A. (462 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
N4BP1NEDD4 binding protein 1. (810 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
EP300E1A binding protein p300. (2416 aa)
RBX1Ring-box 1. (108 aa)
ATF4Activating transcription factor 4. (351 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
ENSCSAP00000003275Uncharacterized protein. (261 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
BMFBcl2 modifying factor. (184 aa)
SIRT1Sirtuin 1. (743 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
RHBDD1Rhomboid domain containing 1. (316 aa)
MFAP4Microfibril associated protein 4. (255 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
CRIP1LIM zinc-binding domain-containing protein. (77 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (888 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (402 aa)
ENSCSAP00000005812KOW domain-containing protein. (119 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CREBBPCREB binding protein. (2417 aa)
NPM1Nucleophosmin 1. (294 aa)
TAF1LTATA-box binding protein associated factor 1 like. (1476 aa)
OPN1SWOpsin 1, short wave sensitive. (349 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ENSCSAP00000006521Uncharacterized protein. (266 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
RPL26Ribosomal protein L26. (145 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
XPAXPA, DNA damage recognition and repair factor. (226 aa)
TAF1Transcription initiation factor TFIID subunit. (1894 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
NEDD4E3 ubiquitin-protein ligase. (900 aa)
DHX36DEAH-box helicase 36. (1007 aa)
POLHDNA polymerase eta. (712 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (165 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (572 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
ZBTB1Zinc finger and BTB domain containing 1. (644 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (515 aa)
HYAL2Hyaluronidase. (473 aa)
HYAL1Hyaluronidase. (450 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
ENSCSAP00000010702Nucleoplasmin domain-containing protein. (275 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
POLKDNA polymerase kappa. (847 aa)
C9orf116Chromosome 9 open reading frame 116. (136 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CDC25ACell division cycle 25A. (523 aa)
PBKPDZ binding kinase. (322 aa)
SDE2SDE2 telomere maintenance homolog. (451 aa)
PARP1Poly(ADP-ribose) polymerase 1. (709 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1461 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
ENSCSAP00000013063Uncharacterized protein. (278 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
IMPACTImpact RWD domain protein. (320 aa)
CUL4BCullin 4B; Belongs to the cullin family. (900 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
ENSCSAP00000014836Uncharacterized protein. (329 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1139 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
CHEK1Checkpoint kinase 1. (749 aa)
TRIAP1TP53 regulated inhibitor of apoptosis 1. (76 aa)
POLD1DNA polymerase. (1086 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (872 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (415 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (756 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
ENSCSAP00000017875Uncharacterized protein. (370 aa)
ENSCSAP00000017976Uncharacterized protein. (145 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (317 aa)
NSMCE3NSE3 homolog, SMC5-SMC6 complex component. (304 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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