STRINGSTRING
TENM4 TENM4 PSAPL1 PSAPL1 RAG2 RAG2 FOXC1 FOXC1 SPRY2 SPRY2 FOXC2 FOXC2 S1PR1 S1PR1 TSKU TSKU MATN1 MATN1 ZMPSTE24 ZMPSTE24 LEPR LEPR TGFBR3 TGFBR3 THBS3 THBS3 TBX5 TBX5 PTPN11 PTPN11 DDR2 DDR2 RARA RARA SORBS2 SORBS2 MMP13 MMP13 YAP1 YAP1 SMAD1 SMAD1 ENSCSAP00000014410 ENSCSAP00000014410 BCL2 BCL2 ECM1 ECM1 FGF9 FGF9 SMAD2 SMAD2 IER3IP1 IER3IP1 GATA6 GATA6 ENSCSAP00000013468 ENSCSAP00000013468 AKAP13 AKAP13 MESP1 MESP1 PRLR PRLR GATA4 GATA4 FGF10 FGF10 HEY2 HEY2 STC1 STC1 EVC EVC ENSCSAP00000012148 ENSCSAP00000012148 ADRA1A ADRA1A HLX HLX NOTCH1 NOTCH1 TGFB2 TGFB2 FGFR3 FGFR3 SAV1 SAV1 BMP10 BMP10 PLAG1 PLAG1 ATF2 ATF2 ACVR2B ACVR2B ARX ARX ESR1 ESR1 IL7 IL7 COL27A1 COL27A1 STK3 STK3 IFT80 IFT80 AR AR DLL1 DLL1 RSPO2 RSPO2 PDGFRB PDGFRB TMEM38B TMEM38B DIPK2A DIPK2A ANKRD30B ANKRD30B CYP19A1 CYP19A1 ANXA6 ANXA6 WNT2 WNT2 EXT1 EXT1 FGF7 FGF7 LEP LEP RARB RARB TGFBR2 TGFBR2 NKX2-5 NKX2-5 BNC2 BNC2 CER1 CER1 MAP2K4 MAP2K4 EHMT2 EHMT2 OSTN OSTN PSAP PSAP FXN FXN HEG1 HEG1 ENSCSAP00000003965 ENSCSAP00000003965 JARID2 JARID2 PTEN PTEN ARID2 ARID2 NPPC NPPC SHH SHH UBE3A UBE3A RARG RARG FGF8 FGF8 COMP COMP MAPK11 MAPK11 NDRG4 NDRG4 FGFR2 FGFR2 SOX9 SOX9 PDLIM5 PDLIM5 SMPD3 SMPD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TENM4Teneurin transmembrane protein 4. (2605 aa)
PSAPL1Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. (521 aa)
RAG2Recombination activating 2. (527 aa)
FOXC1Forkhead box C1. (552 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
FOXC2Forkhead box C2. (501 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
MATN1Matrilin 1. (496 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
LEPRLeptin receptor. (1163 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
THBS3Thrombospondin 3. (947 aa)
TBX5T-box transcription factor 5. (518 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
RARARetinoic acid receptor alpha. (462 aa)
SORBS2Sorbin and SH3 domain containing 2. (1524 aa)
MMP13Matrix metallopeptidase 13. (471 aa)
YAP1Yes associated protein 1. (508 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ENSCSAP00000014410ANK_REP_REGION domain-containing protein. (583 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ECM1Extracellular matrix protein 1. (540 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
IER3IP1Immediate early response 3 interacting protein 1. (82 aa)
GATA6GATA binding protein 6. (595 aa)
ENSCSAP00000013468Uncharacterized protein. (1924 aa)
AKAP13A-kinase anchoring protein 13. (2854 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)
GATA4GATA binding protein 4. (442 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
STC1Stanniocalcin 1. (247 aa)
EVCEvC ciliary complex subunit 1. (948 aa)
ENSCSAP00000012148ANK_REP_REGION domain-containing protein. (397 aa)
ADRA1AAdrenoceptor alpha 1A. (425 aa)
HLXH2.0 like homeobox. (494 aa)
NOTCH1Notch receptor 1. (2555 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
SAV1Salvador family WW domain containing protein 1. (385 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
PLAG1PLAG1 zinc finger. (500 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (354 aa)
ARXAristaless related homeobox. (562 aa)
ESR1Estrogen receptor 1. (487 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
COL27A1Collagen type XXVII alpha 1 chain. (1860 aa)
STK3Serine/threonine kinase 3. (491 aa)
IFT80Intraflagellar transport 80. (768 aa)
ARAndrogen receptor. (900 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
RSPO2R-spondin 2. (243 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
ANKRD30BAnkyrin repeat domain 30B. (1370 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
ANXA6Annexin. (676 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (420 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
LEPLeptin. (199 aa)
RARBRetinoic acid receptor beta. (448 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
NKX2-5NK2 homeobox 5. (324 aa)
BNC2Basonuclin 2. (1099 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (363 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1197 aa)
OSTNOsteocrin. (133 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (524 aa)
FXNFrataxin. (210 aa)
HEG1Heart development protein with EGF like domains 1. (1323 aa)
ENSCSAP00000003965Uncharacterized protein. (1421 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1246 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ARID2AT-rich interaction domain 2. (1687 aa)
NPPCNatriuretic peptide C. (126 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (872 aa)
RARGRetinoic acid receptor gamma. (443 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
NDRG4NDRG family member 4. (391 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
SOX9SRY-box transcription factor 9. (509 aa)
PDLIM5PDZ and LIM domain 5. (546 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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