STRINGSTRING
GPER1 GPER1 GJA5 GJA5 CHRM3 CHRM3 KCNA5 KCNA5 KCNA1 KCNA1 GJC1 GJC1 PLN PLN KCNE4 KCNE4 KCNE1 KCNE1 KCNE2 KCNE2 GPR88 GPR88 S1PR1 S1PR1 KCNA2 KCNA2 KCNE5 KCNE5 KCNJ2 KCNJ2 KCNE3 KCNE3 RNF207 RNF207 MTOR MTOR SLC9A1 SLC9A1 ZMPSTE24 ZMPSTE24 CLDN19 CLDN19 LOC103224612 LOC103224612 KCND3 KCND3 CACNG8 CACNG8 CACNG7 CACNG7 HCN3 HCN3 JAM3 JAM3 MYH14 MYH14 P2RX4 P2RX4 P2RX7 P2RX7 KCNJ5 KCNJ5 TBX5 TBX5 SCN2B SCN2B SCN4B SCN4B TRPM4 TRPM4 JUP JUP CNTNAP1 CNTNAP1 ATP1A3 ATP1A3 DSG2 DSG2 DSC2 DSC2 NUP155 NUP155 MEF2A MEF2A BIN1 BIN1 HCN1 HCN1 ISL1 ISL1 GJA1 GJA1 CACNB4 CACNB4 KCNJ3 KCNJ3 SCN3A SCN3A SCN2A SCN2A SCN1A SCN1A SCN9A SCN9A SCN7A SCN7A CHRNB4 CHRNB4 KCNN2 KCNN2 GRIK2 GRIK2 SCN11A SCN11A NFASC NFASC SCN10A SCN10A CHRNA1 CHRNA1 SCN5A SCN5A YWHAE YWHAE HCN4 HCN4 P2RX1 P2RX1 RGS21 RGS21 CACNA1D CACNA1D HCN2 HCN2 KCNMB3 KCNMB3 KCNMB2 KCNMB2 CACNB2 CACNB2 AKAP9 AKAP9 SLC8A1 SLC8A1 CACNA2D1 CACNA2D1 CACNA1H CACNA1H ATP1B2 ATP1B2 CACNA1C CACNA1C NRCAM NRCAM CAV1 CAV1 GLRA1 GLRA1 KCND2 KCND2 RYR2 RYR2 KCNQ1 KCNQ1 PMP22 PMP22 CXADR CXADR PLEC PLEC DMRT3 DMRT3 FKBP1B FKBP1B ABCC9 ABCC9 CACNG2 CACNG2 SLC4A3 SLC4A3 NTRK2 NTRK2 CTNNA3 CTNNA3 DSP DSP ANK3 ANK3 PKP2 PKP2 CLCN1 CLCN1 GJD2 GJD2 OTOA OTOA KCNH2 KCNH2 CACNA1I CACNA1I P2RX3 P2RX3 SCN8A SCN8A CACNA1G CACNA1G SCN1B SCN1B MAG MAG CACNG4 CACNG4 CACNG5 CACNG5 SCN4A SCN4A KCNH6 KCNH6 ANK2 ANK2 ENSCSAP00000000163 ENSCSAP00000000163 SPTBN4 SPTBN4 CHRM5 CHRM5 DRD5 DRD5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (170 aa)
KCNE1Uncharacterized protein. (146 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
GPR88G protein-coupled receptor 88. (384 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
RNF207Ring finger protein 207. (599 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (181 aa)
LOC103224612Uncharacterized protein. (835 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (421 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (777 aa)
JAM3Junctional adhesion molecule 3. (364 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (358 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (491 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (432 aa)
TBX5T-box transcription factor 5. (518 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1214 aa)
JUPJunction plakoglobin. (745 aa)
CNTNAP1Contactin associated protein 1. (1382 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1013 aa)
DSG2Desmoglein 2. (1118 aa)
DSC2Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (901 aa)
NUP155Nucleoporin 155. (1080 aa)
MEF2AMyocyte enhancer factor 2A. (503 aa)
BIN1Bridging integrator 1. (608 aa)
HCN1Cyclic nucleotide-binding domain-containing protein. (604 aa)
ISL1ISL LIM homeobox 1. (349 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (486 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1701 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2052 aa)
SCN1ASodium voltage-gated channel alpha subunit 1. (1359 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1992 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1680 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (492 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (846 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (859 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1791 aa)
NFASCNeurofascin. (1437 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1956 aa)
CHRNA1Neur_chan_LBD domain-containing protein. (248 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1881 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (240 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
RGS21Regulator of G protein signaling 21. (149 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2036 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (806 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (286 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (612 aa)
AKAP9A-kinase anchoring protein 9. (3922 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (632 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (962 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2240 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
CACNA1CCalcium voltage-gated channel subunit alpha1 C. (1898 aa)
NRCAMNeuronal cell adhesion molecule. (1298 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (389 aa)
RYR2Ryanodine receptor 2. (4906 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (518 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
CXADRCXADR Ig-like cell adhesion molecule. (352 aa)
PLECPlectin. (4605 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ABCC9ATP binding cassette subfamily C member 9. (1549 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
SLC4A3Anion exchange protein. (1232 aa)
NTRK2Neurotrophic receptor tyrosine kinase 2. (477 aa)
CTNNA3Uncharacterized protein. (305 aa)
DSPDesmoplakin. (2871 aa)
ANK3Ankyrin 3. (2797 aa)
PKP2Plakophilin 2. (837 aa)
CLCN1Chloride channel protein. (988 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (321 aa)
OTOAOtoancorin. (1153 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1160 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2234 aa)
P2RX3Purinergic receptor P2X 3. (298 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2186 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (218 aa)
MAGMyelin associated glycoprotein. (626 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (278 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1836 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (994 aa)
ANK2Ankyrin 2. (4035 aa)
ENSCSAP00000000163Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (489 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2568 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (478 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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