STRINGSTRING
TSG101 TSG101 VPS4A VPS4A CHMP2A CHMP2A MVB12A MVB12A VPS37C VPS37C VPS28 VPS28 PDCD6IP PDCD6IP UBAP1 UBAP1 CHMP4B CHMP4B STAM STAM CHMP4C CHMP4C MVB12B MVB12B CHMP4A CHMP4A STAM2 STAM2 VPS37A VPS37A VPS36 VPS36 VPS25 VPS25 SNF8 SNF8 HGS HGS VPS37B VPS37B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSG101Tumor susceptibility 101. (390 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
MVB12AMultivesicular body subunit 12A. (273 aa)
VPS37CVPS37C subunit of ESCRT-I. (355 aa)
VPS28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (231 aa)
PDCD6IPBRO1 domain-containing protein. (868 aa)
UBAP1Ubiquitin associated protein 1. (502 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
STAMSignal transducing adaptor molecule. (540 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
MVB12BMultivesicular body subunit 12B. (321 aa)
CHMP4ACharged multivesicular body protein 4A. (222 aa)
STAM2Signal transducing adaptor molecule 2. (525 aa)
VPS37AVPS37A subunit of ESCRT-I. (396 aa)
VPS36Vacuolar protein sorting 36 homolog. (386 aa)
VPS25Vacuolar protein sorting 25 homolog. (176 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
VPS37BVPS37B subunit of ESCRT-I. (285 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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