STRINGSTRING
FANCC FANCC ENSCSAP00000002882 ENSCSAP00000002882 FAN1 FAN1 RAD51 RAD51 FAAP24 FAAP24 DCLRE1A DCLRE1A RNF168 RNF168 XRCC3 XRCC3 SLX4 SLX4 FANCE FANCE FANCD2 FANCD2 VCP VCP FANCG FANCG ENSCSAP00000007123 ENSCSAP00000007123 XPA XPA RAD51AP1 RAD51AP1 ATR ATR FANCL FANCL NUCKS1 NUCKS1 FANCB FANCB FANCM FANCM POLN POLN MCM9 MCM9 FANCI FANCI HROB HROB ERCC1 ERCC1 NEIL3 NEIL3 FANCA FANCA ENSCSAP00000015863 ENSCSAP00000015863 DCLRE1B DCLRE1B ENSCSAP00000017299 ENSCSAP00000017299 EXO5 EXO5 FANCF FANCF RFWD3 RFWD3 RAD51AP2 RAD51AP2 ERCC4 ERCC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (559 aa)
ENSCSAP00000002882Uncharacterized protein. (1547 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
FAAP24FA core complex associated protein 24. (215 aa)
DCLRE1ADNA cross-link repair 1A. (1040 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
SLX4Uncharacterized protein. (929 aa)
FANCEFA complementation group E. (323 aa)
FANCD2Uncharacterized protein. (1458 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
FANCGFA complementation group G. (622 aa)
ENSCSAP00000007123RAD51_interact domain-containing protein. (319 aa)
XPAXPA, DNA damage recognition and repair factor. (226 aa)
RAD51AP1RAD51 associated protein 1. (354 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
FANCLFA complementation group L. (461 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa)
FANCBFA complementation group B. (859 aa)
FANCMFA complementation group M. (2050 aa)
POLNDNA polymerase nu. (663 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
FANCIFA complementation group I. (1199 aa)
HROBChromosome 17 open reading frame 53. (652 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
NEIL3Nei like DNA glycosylase 3. (601 aa)
FANCAFA complementation group A. (1455 aa)
ENSCSAP00000015863Uncharacterized protein. (81 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
ENSCSAP00000017299Uncharacterized protein. (179 aa)
EXO5Exonuclease 5. (373 aa)
FANCFFA complementation group F. (374 aa)
RFWD3Ring finger and WD repeat domain 3. (774 aa)
RAD51AP2RAD51 associated protein 2. (1161 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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