Your Input: | |||||
FANCC | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (559 aa) | ||||
ENSCSAP00000002882 | Uncharacterized protein. (1547 aa) | ||||
FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa) | ||||
RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) | ||||
FAAP24 | FA core complex associated protein 24. (215 aa) | ||||
DCLRE1A | DNA cross-link repair 1A. (1040 aa) | ||||
RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) | ||||
XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) | ||||
SLX4 | Uncharacterized protein. (929 aa) | ||||
FANCE | FA complementation group E. (323 aa) | ||||
FANCD2 | Uncharacterized protein. (1458 aa) | ||||
VCP | Valosin containing protein; Belongs to the AAA ATPase family. (806 aa) | ||||
FANCG | FA complementation group G. (622 aa) | ||||
ENSCSAP00000007123 | RAD51_interact domain-containing protein. (319 aa) | ||||
XPA | XPA, DNA damage recognition and repair factor. (226 aa) | ||||
RAD51AP1 | RAD51 associated protein 1. (354 aa) | ||||
ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) | ||||
FANCL | FA complementation group L. (461 aa) | ||||
NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) | ||||
FANCB | FA complementation group B. (859 aa) | ||||
FANCM | FA complementation group M. (2050 aa) | ||||
POLN | DNA polymerase nu. (663 aa) | ||||
MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa) | ||||
FANCI | FA complementation group I. (1199 aa) | ||||
HROB | Chromosome 17 open reading frame 53. (652 aa) | ||||
ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) | ||||
NEIL3 | Nei like DNA glycosylase 3. (601 aa) | ||||
FANCA | FA complementation group A. (1455 aa) | ||||
ENSCSAP00000015863 | Uncharacterized protein. (81 aa) | ||||
DCLRE1B | DNA cross-link repair 1B. (532 aa) | ||||
ENSCSAP00000017299 | Uncharacterized protein. (179 aa) | ||||
EXO5 | Exonuclease 5. (373 aa) | ||||
FANCF | FA complementation group F. (374 aa) | ||||
RFWD3 | Ring finger and WD repeat domain 3. (774 aa) | ||||
RAD51AP2 | RAD51 associated protein 2. (1161 aa) | ||||
ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (735 aa) |