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| | CMTM7 | CKLF like MARVEL transmembrane domain containing 7. (125 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | CD70 | CD70 molecule; Belongs to the tumor necrosis factor family. (194 aa) |
| | EXO1 | Exonuclease 1. (845 aa) |
| | BCL6 | BCL6 transcription repressor. (708 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) |
| | TBC1D10C | TBC1 domain family member 10C. (446 aa) |
| | CLCF1 | Cardiotrophin like cytokine factor 1. (322 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | SASH3 | SAM and SH3 domain containing 3. (380 aa) |
| | ICOSLG | Uncharacterized protein. (302 aa) |
| | DOCK10 | Dedicator of cytokinesis 10; Belongs to the DOCK family. (2187 aa) |
| | SYVN1 | Synoviolin 1. (617 aa) |
| | MFNG | Beta-1,3-N-acetylglucosaminyltransferase. (321 aa) |
| | CD40LG | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa) |
| | CD86 | CD86 molecule. (329 aa) |
| | LGALS1 | Galectin. (135 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | RASGRP1 | RAS guanyl releasing protein 1. (659 aa) |
| | RABL3 | RAB, member of RAS oncogene family like 3. (233 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (824 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | GIMAP1 | GTPase, IMAP family member 1. (306 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa) |
| | HHEX | Hematopoietically expressed homeobox. (268 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1838 aa) |
| | LYL1 | LYL1 basic helix-loop-helix family member. (280 aa) |
| | ENSCSAP00000002631 | Ig-like domain-containing protein. (162 aa) |
| | ENSCSAP00000002624 | Uncharacterized protein. (279 aa) |
| | ENSCSAP00000002584 | Prohibitin. (259 aa) |
| | MS4A1 | Membrane spanning 4-domains A1. (297 aa) |
| | BLNK | B cell linker. (453 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1088 aa) |
| | PTPRJ | Protein tyrosine phosphatase receptor type J. (1333 aa) |
| | EP300 | E1A binding protein p300. (2416 aa) |
| | NKX2-3 | NK2 homeobox 3. (319 aa) |
| | NFAM1 | NFAT activating protein with ITAM motif 1. (272 aa) |
| | BST2 | Bone marrow stromal cell antigen 2. (182 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (953 aa) |
| | JAK3 | Tyrosine-protein kinase. (1069 aa) |
| | PIK3R2 | Uncharacterized protein. (629 aa) |
| | KIT | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | ADGRG3 | Adhesion G protein-coupled receptor G3; Belongs to the G-protein coupled receptor 2 family. (556 aa) |
| | SWAP70 | Switching B cell complex subunit SWAP70. (585 aa) |
| | CD22 | CD22 molecule. (736 aa) |
| | BANK1 | B cell scaffold protein with ankyrin repeats 1. (764 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (331 aa) |
| | CD79B | CD79b molecule. (231 aa) |
| | IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (155 aa) |
| | BCL3 | BCL3 transcription coactivator. (358 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | IRF8 | Interferon regulatory factor 8. (426 aa) |
| | STAT5B | Signal transducer and activator of transcription. (787 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | POU2AF1 | POU class 2 homeobox associating factor 1. (187 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (304 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | IKZF3 | IKAROS family zinc finger 3. (509 aa) |
| | CXCR5 | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | SLAMF8 | SLAM family member 8. (285 aa) |
| | PHB | Prohibitin. (272 aa) |
| | C17orf99 | Chromosome 17 open reading frame 99. (221 aa) |
| | FCRL1 | Fc receptor like 1. (426 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (796 aa) |
| | GON4L | Gon-4 like. (2244 aa) |
| | YY1AP1 | YY1 associated protein 1. (797 aa) |
| | CHRNB2 | Cholinergic receptor nicotinic beta 2 subunit. (442 aa) |
| | NOTCH2 | Notch receptor 2. (2471 aa) |
| | VCAM1 | Vascular cell adhesion molecule 1. (739 aa) |
| | ENSCSAP00000016690 | Prohibitin. (261 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | CTPS1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa) |
| | TXLNA | Taxilin alpha. (546 aa) |
| | EPHB2 | EPH receptor B2. (975 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | IFNK | Interferon kappa. (207 aa) |
| | ENSCSAP00000017563 | Uncharacterized protein. (189 aa) |
| | ENSCSAP00000017564 | Uncharacterized protein. (189 aa) |
| | IFNA6 | Interferon alpha 6. (189 aa) |
| | IFNA14 | Interferon alpha 14. (189 aa) |
| | ENSCSAP00000017567 | Uncharacterized protein. (189 aa) |
| | ENSCSAP00000017568 | Uncharacterized protein. (189 aa) |
| | ENSCSAP00000017569 | Uncharacterized protein. (189 aa) |
| | IFNW1 | Interferon omega 1. (195 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | ENSCSAP00000017599 | annotation not available (271 aa) |
| | ENSCSAP00000017683 | Prohibitin. (272 aa) |
| | GPR183 | G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | ENSCSAP00000017839 | A_deaminase domain-containing protein. (363 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (150 aa) |
| | TICAM1 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (711 aa) |
| | GAPT | GRB2 binding adaptor protein, transmembrane. (157 aa) |
| | RAG2 | Recombination activating 2. (527 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | CD79A | CD79a molecule. (199 aa) |
| | DOCK11 | Dedicator of cytokinesis 11; Belongs to the DOCK family. (2041 aa) |
| | LAT2 | Linker for activation of T cells family member 2. (243 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | MALT1 | MALT1 paracaspase. (729 aa) |
| | AKAP17A | A-kinase anchoring protein 17A. (386 aa) |
| | FLT3 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (805 aa) |
| | LFNG | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (236 aa) |
| | PTPN2 | Protein tyrosine phosphatase non-receptor type 2. (298 aa) |
| | TNFSF13B | TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | IL7R | Interleukin 7 receptor. (459 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | CD38 | CD38 molecule. (304 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa) |
| | CD180 | CD180 molecule. (661 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | TRAF3IP2 | TRAF3 interacting protein 2. (563 aa) |
| | CR2 | Complement C3d receptor 2. (1093 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4131 aa) |
| | ABL1 | Tyrosine-protein kinase. (1130 aa) |
| | CD40 | CD40 molecule. (278 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (446 aa) |
| | SP3 | Sp3 transcription factor. (781 aa) |
| | KIAA1841 | KIAA1841. (718 aa) |
| | LRRC8A | Leucine rich repeat containing 8 VRAC subunit A. (810 aa) |
| | LAX1 | Lymphocyte transmembrane adaptor 1. (398 aa) |
| | SKAP2 | Src kinase associated phosphoprotein 2. (256 aa) |
| | ADA | A_deaminase domain-containing protein. (411 aa) |
| | MLH1 | MutL homolog 1. (756 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1507 aa) |
| | FNIP1 | Folliculin interacting protein 1. (1166 aa) |
| | KLF6 | Kruppel like factor 6. (283 aa) |
| | ZBTB1 | Zinc finger and BTB domain containing 1. (644 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1309 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa) |
| | ENSCSAP00000009708 | Hist_deacetyl domain-containing protein. (156 aa) |
| | ENSCSAP00000009705 | Hist_deacetyl domain-containing protein. (114 aa) |
| | HDAC9 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (780 aa) |
| | IL7 | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa) |
| | ENSCSAP00000009529 | Uncharacterized protein. (278 aa) |
| | IL9 | Uncharacterized protein. (145 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | ITGA4 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | FOXP3 | Forkhead box P3. (358 aa) |
| | CDH17 | Cadherin 17. (832 aa) |
| | BATF | Basic leucine zipper ATF-like transcription factor. (125 aa) |
| | CCR6 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (374 aa) |
| | TCF3 | Transcription factor 3. (581 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa) |
| | TSHR | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (708 aa) |
| | IL2RG | Fibronectin type-III domain-containing protein. (369 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | ITFG2 | Integrin alpha FG-GAP repeat containing 2. (447 aa) |
| | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9. (222 aa) |
| | SHB | SH2 domain containing adaptor protein B. (509 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (496 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (584 aa) |
| | PAX5 | Paired box 5. (391 aa) |
| | ITM2A | Integral membrane protein 2A. (263 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa) |
| | PHB2 | Prohibitin. (288 aa) |
| | IRF2BP2 | Interferon regulatory factor 2 binding protein 2. (587 aa) |
| | DEF6 | DEF6 guanine nucleotide exchange factor. (631 aa) |
| | PLCL2 | Phosphoinositide phospholipase C. (1127 aa) |
| | BTK | Tyrosine-protein kinase. (497 aa) |
| | ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (340 aa) |
| | IFNE | Interferon epsilon. (207 aa) |
| | IFNA8 | Interferon alpha 8. (195 aa) |
| | IFNA2 | Interferon alpha 2. (190 aa) |
| | AICDA | Activation induced cytidine deaminase. (196 aa) |
