STRINGSTRING
CTNNB1 CTNNB1 BCL2L11 BCL2L11 FGF10 FGF10 GLI2 GLI2 FST FST MSX1 MSX1 ACVR2A ACVR2A LAMA5 LAMA5 ITGB6 ITGB6 HDAC2 HDAC2 BMP7 BMP7 GLI3 GLI3 AMELX AMELX BMP4 BMP4 DLX1 DLX1 DLX2 DLX2 SCN10A SCN10A SCN5A SCN5A ATF2 ATF2 ACVR2B ACVR2B BMP2 BMP2 SOSTDC1 SOSTDC1 CTNNA1 CTNNA1 BSG BSG RUNX2 RUNX2 TBX1 TBX1 EDA EDA CCDC154 CCDC154 WDR72 WDR72 SLC24A4 SLC24A4 CFTR CFTR HAND1 HAND1 BCL11B BCL11B SMO SMO BMPR1A BMPR1A NF2 NF2 JAG2 JAG2 FGF4 FGF4 TP63 TP63 ROGDI ROGDI SLC34A1 SLC34A1 TCIRG1 TCIRG1 WNT6 WNT6 SHH SHH NKX2-3 NKX2-3 LRP4 LRP4 TRAF6 TRAF6 PPARA PPARA DLX3 DLX3 ODAM ODAM AMBN AMBN ENAM ENAM HTRA1 HTRA1 ADM ADM STIM1 STIM1 FAM20A FAM20A SMPD3 SMPD3 RELT RELT LEF1 LEF1 FOXC1 FOXC1 ENSCSAP00000017750 ENSCSAP00000017750 HDAC1 HDAC1 LHX8 LHX8 ENSCSAP00000016053 ENSCSAP00000016053 KLK5 KLK5 KLK4 KLK4 NGFR NGFR NECTIN1 NECTIN1 BAX BAX ANKRD11 ANKRD11 HAND2 HAND2 MMP20 MMP20 TGFB1 TGFB1 SERPINE1 SERPINE1 GATA6 GATA6 FAM20C FAM20C CNNM4 CNNM4 EDAR EDAR PERP PERP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTNNB1Catenin beta 1. (781 aa)
BCL2L11BCL2 like 11. (109 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GLI2GLI family zinc finger 2. (1554 aa)
FSTFollistatin. (344 aa)
MSX1Msh homeobox 1. (303 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GLI3GLI family zinc finger 3. (1459 aa)
AMELXAmelogenin X-linked. (191 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
DLX1Distal-less homeobox 1. (255 aa)
DLX2Distal-less homeobox 2. (329 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1956 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1881 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (354 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
CTNNA1Catenin alpha 1. (906 aa)
BSGBasigin (Ok blood group). (385 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (450 aa)
TBX1T-box transcription factor 1. (490 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (260 aa)
CCDC154Coiled-coil domain containing 154. (674 aa)
WDR72WD repeat domain 72. (1100 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (552 aa)
CFTRCFTR_R domain-containing protein. (289 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NF2Neurofibromin 2. (590 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1245 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (500 aa)
ROGDIRogdi atypical leucine zipper. (287 aa)
SLC34A1Solute carrier family 34 member 1. (639 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
NKX2-3NK2 homeobox 3. (319 aa)
LRP4LDL receptor related protein 4. (1669 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (538 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
DLX3Distal-less homeobox 3. (287 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
AMBNAmeloblastin. (447 aa)
ENAMEnamelin. (1139 aa)
HTRA1HtrA serine peptidase 1. (524 aa)
ADMAdrenomedullin. (185 aa)
STIM1Stromal interaction molecule 1. (684 aa)
FAM20AFAM20A golgi associated secretory pathway pseudokinase. (533 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
RELTRELT TNF receptor. (430 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
FOXC1Forkhead box C1. (552 aa)
ENSCSAP00000017750Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
LHX8LIM homeobox 8. (352 aa)
ENSCSAP00000016053Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (497 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (293 aa)
KLK4Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (254 aa)
NGFRNerve growth factor receptor. (427 aa)
NECTIN1Nectin cell adhesion molecule 1. (519 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ANKRD11Ankyrin repeat domain 11. (2622 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
GATA6GATA binding protein 6. (595 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (584 aa)
CNNM4Cyclin and CBS domain divalent metal cation transport mediator 4. (727 aa)
EDAREctodysplasin A receptor. (450 aa)
PERPP53 apoptosis effector related to PMP22. (193 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.