node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP2 | BMP4 | ENSCSAP00000009677 | ENSCSAP00000010950 | Bone morphogenetic protein 2. | Bone morphogenetic protein 4. | 0.937 |
BMP2 | FGF8 | ENSCSAP00000009677 | ENSCSAP00000001820 | Bone morphogenetic protein 2. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.434 |
BMP2 | RUNX2 | ENSCSAP00000009677 | ENSCSAP00000008664 | Bone morphogenetic protein 2. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.754 |
BMP4 | BMP2 | ENSCSAP00000010950 | ENSCSAP00000009677 | Bone morphogenetic protein 4. | Bone morphogenetic protein 2. | 0.937 |
BMP4 | FGF8 | ENSCSAP00000010950 | ENSCSAP00000001820 | Bone morphogenetic protein 4. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.616 |
BMP4 | RUNX2 | ENSCSAP00000010950 | ENSCSAP00000008664 | Bone morphogenetic protein 4. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.564 |
BMP4 | WNT10A | ENSCSAP00000010950 | ENSCSAP00000004859 | Bone morphogenetic protein 4. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.447 |
CSF1 | NGFR | ENSCSAP00000016469 | ENSCSAP00000015601 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Nerve growth factor receptor. | 0.657 |
FGF8 | BMP2 | ENSCSAP00000001820 | ENSCSAP00000009677 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Bone morphogenetic protein 2. | 0.434 |
FGF8 | BMP4 | ENSCSAP00000001820 | ENSCSAP00000010950 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Bone morphogenetic protein 4. | 0.616 |
FGF8 | NGFR | ENSCSAP00000001820 | ENSCSAP00000015601 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Nerve growth factor receptor. | 0.677 |
NGFR | CSF1 | ENSCSAP00000015601 | ENSCSAP00000016469 | Nerve growth factor receptor. | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | 0.657 |
NGFR | FGF8 | ENSCSAP00000015601 | ENSCSAP00000001820 | Nerve growth factor receptor. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.677 |
RUNX2 | BMP2 | ENSCSAP00000008664 | ENSCSAP00000009677 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | Bone morphogenetic protein 2. | 0.754 |
RUNX2 | BMP4 | ENSCSAP00000008664 | ENSCSAP00000010950 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | Bone morphogenetic protein 4. | 0.564 |
WNT10A | BMP4 | ENSCSAP00000004859 | ENSCSAP00000010950 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | Bone morphogenetic protein 4. | 0.447 |