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| | APIP | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (242 aa) |
| | ALOXE3 | Arachidonate lipoxygenase 3. (714 aa) |
| | ALOX12B | Arachidonate 12-lipoxygenase, 12R type. (701 aa) |
| | SLC27A2 | Solute carrier family 27 member 2. (539 aa) |
| | PCCB | Propionyl-CoA carboxylase subunit beta. (539 aa) |
| | ALOX15B | Arachidonate 15-lipoxygenase type B. (676 aa) |
| | MIF | Macrophage migration inhibitory factor. (115 aa) |
| | RBP1 | Retinol binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa) |
| | BAAT | Bile acid-CoA:amino acid N-acyltransferase. (418 aa) |
| | PNPLA8 | Patatin like phospholipase domain containing 8. (782 aa) |
| | PLOD2 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (758 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | CD74 | CD74 molecule. (294 aa) |
| | NOXRED1 | NADP dependent oxidoreductase domain containing 1. (359 aa) |
| | TMED8 | Transmembrane p24 trafficking protein family member 8. (257 aa) |
| | ALDH1A2 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa) |
| | GGT7 | Gamma-glutamyltransferase 7. (662 aa) |
| | LIPC | Lipase C, hepatic type. (499 aa) |
| | GAD2 | Glutamate decarboxylase 2. (585 aa) |
| | GAMT | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (236 aa) |
| | GLS | Glutaminase. (669 aa) |
| | ALOX12 | Arachidonate 12-lipoxygenase, 12S type. (663 aa) |
| | ENSCSAP00000008436 | Uncharacterized protein. (665 aa) |
| | QKI | QKI, KH domain containing RNA binding. (341 aa) |
| | GOT2 | Aspartate aminotransferase. (430 aa) |
| | ARMC7 | Armadillo repeat containing 7. (198 aa) |
| | MTHFD2L | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (386 aa) |
| | SHMT2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa) |
| | LDHC | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (216 aa) |
| | GLS2 | Glutaminase 2. (602 aa) |
| | TECRL | Trans-2,3-enoyl-CoA reductase like. (326 aa) |
| | MGST3 | Microsomal glutathione S-transferase 3. (152 aa) |
| | ELOVL3 | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa) |
| | HSD17B12 | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa) |
| | SCD | Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa) |
| | MCAT | Malonyl-CoA-acyl carrier protein transacylase. (390 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | GOT1 | Aspartate aminotransferase. (413 aa) |
| | HSD3B7 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (369 aa) |
| | HOGA1 | 4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (327 aa) |
| | ENSCSAP00000002230 | FA_desaturase domain-containing protein. (370 aa) |
| | PRG3 | Proteoglycan 3, pro eosinophil major basic protein 2. (225 aa) |
| | PER2 | Period circadian regulator 2. (1254 aa) |
| | ACACA | Acetyl-CoA carboxylase alpha. (2346 aa) |
| | ELOVL6 | Elongation of very long chain fatty acids protein. (192 aa) |
| | HPGDS | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa) |
| | SCD5 | Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (344 aa) |
| | ENOPH1 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (261 aa) |
| | UROS | Uroporphyrinogen III synthase. (308 aa) |
| | OAT | Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa) |
| | THNSL1 | Threonine synthase like 1. (743 aa) |
| | HTD2 | Hydroxyacyl-thioester dehydratase type 2. (168 aa) |
| | CYP8B1 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa) |
| | PRXL2B | Peroxiredoxin like 2B. (230 aa) |
| | ACOT7 | Acyl-CoA thioesterase 7. (370 aa) |
| | PARK7 | Parkinsonism associated deglycase. (189 aa) |
| | PLA2G5 | Phospholipase A(2). (138 aa) |
| | MECR | Mitochondrial trans-2-enoyl-CoA reductase. (373 aa) |
| | EDN2 | Endothelin 2. (178 aa) |
| | AKR1A1 | Aldo-keto reductase family 1 member A1. (325 aa) |
| | ENSCSAP00000016771 | Uncharacterized protein. (433 aa) |
| | CYP4A22 | Uncharacterized protein. (455 aa) |
| | SCP2 | Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | CTH | Cystathionine gamma-lyase. (405 aa) |
| | ABCD3 | ATP binding cassette subfamily D member 3. (659 aa) |
| | DPYD | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa) |
| | GSTM4 | Glutathione S-transferase mu 4. (218 aa) |
| | GSTM5 | Glutathione S-transferase mu 5. (218 aa) |
| | SLC27A5 | Solute carrier family 27 member 5. (690 aa) |
| | PHGDH | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa) |
| | FASN | Fatty acid synthase. (2510 aa) |
| | CRABP2 | Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa) |
| | PYCR1 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (319 aa) |
| | HNF1A | HNF1 homeobox A. (632 aa) |
| | PLA2G1B | Phospholipase A(2). (148 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | SDSL | Serine dehydratase like. (329 aa) |
| | SDS | Serine dehydratase. (328 aa) |
| | ACACB | Acetyl-CoA carboxylase beta. (2462 aa) |
| | BCAT2 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (352 aa) |
| | ACSF3 | Acyl-CoA synthetase family member 3. (576 aa) |
| | ACLY | ATP citrate lyase. (603 aa) |
| | ENSCSAP00000014978 | Uncharacterized protein; Belongs to the peptidase C14A family. (392 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (462 aa) |
| | CBR4 | Carbonyl reductase 4. (237 aa) |
| | PAH | Phenylalanine hydroxylase. (452 aa) |
| | HSDL1 | Hydroxysteroid dehydrogenase like 1. (330 aa) |
| | MLYCD | Malonyl-CoA decarboxylase. (493 aa) |
| | BRCA1 | Uncharacterized protein. (663 aa) |
| | NAGS | N-acetylglutamate synthase. (534 aa) |
| | MGST2 | Microsomal glutathione S-transferase 2. (147 aa) |
| | LTA4H | Leukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (611 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | ACSS1 | Acyl-CoA synthetase short chain family member 1. (399 aa) |
| | ASL | Argininosuccinate lyase. (464 aa) |
| | NANP | N-acetylneuraminic acid phosphatase. (248 aa) |
| | LIPG | Lipase G, endothelial type. (500 aa) |
| | PLOD3 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (736 aa) |
| | ALOX5AP | Arachidonate 5-lipoxygenase activating protein. (161 aa) |
| | CYP3A4 | Cytochrome P450 family 3 subfamily A member 4; Belongs to the cytochrome P450 family. (359 aa) |
| | OSBPL1A | Oxysterol-binding protein; Belongs to the OSBP family. (949 aa) |
| | DAGLB | Diacylglycerol lipase beta. (668 aa) |
| | ABHD3 | Abhydrolase domain containing 3. (410 aa) |
| | ELOVL4 | Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa) |
| | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (698 aa) |
| | AMACR | Alpha-methylacyl-CoA racemase. (382 aa) |
| | AGXT2 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (513 aa) |
| | SLC1A3 | Amino acid transporter. (542 aa) |
| | UGDH | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (494 aa) |
| | LIAS | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (501 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (393 aa) |
| | ALDH8A1 | Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa) |
| | LPL | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa) |
| | ENSCSAP00000012677 | Uncharacterized protein. (410 aa) |
| | ACMSD | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa) |
| | THNSL2 | Threonine synthase like 2. (519 aa) |
| | PYCR2 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa) |
| | KYNU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (465 aa) |
| | DEGS1 | Delta 4-desaturase, sphingolipid 1. (323 aa) |
| | PSPH | Phosphoserine phosphatase. (142 aa) |
| | PTGDS | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (190 aa) |
| | ELOVL7 | Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (281 aa) |
| | OSBPL2 | Oxysterol-binding protein; Belongs to the OSBP family. (480 aa) |
| | NAIP | NLR family apoptosis inhibitory protein. (1232 aa) |
| | GOT1L1 | Glutamic-oxaloacetic transaminase 1 like 1. (420 aa) |
| | SUGCT | Succinyl-CoA:glutarate-CoA transferase. (332 aa) |
| | ABCB11 | ATP binding cassette subfamily B member 11. (1323 aa) |
| | DHRS9 | Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa) |
| | BHMT2 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. (363 aa) |
| | BHMT | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. (406 aa) |
| | DHFR | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa) |
| | IDO1 | Indoleamine 2,3-dioxygenase 1. (401 aa) |
| | PTGIS | Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (492 aa) |
| | GAD1 | Glutamate decarboxylase 1. (594 aa) |
| | ASS1 | Uncharacterized protein. (140 aa) |
| | PTGES | Prostaglandin E synthase. (145 aa) |
| | ACOT8 | Acyl-CoA thioesterase 8. (319 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa) |
| | MTHFD1L | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (948 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (436 aa) |
| | OSBPL6 | Oxysterol-binding protein; Belongs to the OSBP family. (959 aa) |
| | OSBPL3 | Oxysterol-binding protein; Belongs to the OSBP family. (887 aa) |
| | WDR37 | WD repeat domain 37. (495 aa) |
| | OTC | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa) |
| | LIPH | Lipase H. (451 aa) |
| | PTGES2 | Prostaglandin E synthase 2; Belongs to the GST superfamily. (377 aa) |
| | AKR1C3 | Aldo-keto reductase family 1 member C3. (326 aa) |
| | MTHFD1 | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (1042 aa) |
| | SRR | Serine racemase. (339 aa) |
| | RGN | Regucalcin. (299 aa) |
| | RDH10 | Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa) |
| | TMEM196 | Uncharacterized protein. (104 aa) |
| | HAO1 | Hydroxyacid oxidase 1. (370 aa) |
| | LOC103246731 | Uncharacterized protein. (741 aa) |
| | LGSN | Lengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (509 aa) |
| | PCBD2 | Pterin-4 alpha-carbinolamine dehydratase 2. (130 aa) |
| | PTGS1 | Prostaglandin-endoperoxide synthase 1. (599 aa) |
| | PLA2G4A | Phospholipase A2. (749 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2. (572 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa) |
| | GGT6 | Gamma-glutamyltransferase 6. (492 aa) |
| | ALOX15 | Arachidonate 15-lipoxygenase. (610 aa) |
| | ASNS | Asparagine synthetase [glutamine-hydrolyzing]. (561 aa) |
| | HACD3 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa) |
| | OLAH | Oleoyl-ACP hydrolase. (323 aa) |
| | DECR2 | 2,4-dienoyl-CoA reductase 2. (292 aa) |
| | HACD1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (288 aa) |
| | HAAO | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (300 aa) |
| | CYP39A1 | Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (469 aa) |
| | HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa) |
| | GLUL | Glutamine synthetase. (373 aa) |
| | ASNSD1 | Glutamine amidotransferase type-2 domain-containing protein. (643 aa) |
| | GPX4 | Uncharacterized protein. (109 aa) |
| | OSBP | Oxysterol-binding protein; Belongs to the OSBP family. (805 aa) |
| | ALDH18A1 | Aldehyde dehydrogenase 18 family member A1. (495 aa) |
| | ILVBL | IlvB acetolactate synthase like; Belongs to the TPP enzyme family. (632 aa) |
| | CYP2C8 | Cytochrome P450 family 2 subfamily C member 8; Belongs to the cytochrome P450 family. (490 aa) |
| | CYP2C9 | Uncharacterized protein; Belongs to the cytochrome P450 family. (468 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa) |
| | TECR | Trans-2,3-enoyl-CoA reductase. (308 aa) |
| | MRI1 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (375 aa) |
| | FADS1 | Fatty acid desaturase 1. (501 aa) |
| | FADS2 | Fatty acid desaturase 2. (444 aa) |
| | FADS3 | Fatty acid desaturase 3. (445 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (524 aa) |
| | NDUFAB1 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (112 aa) |
| | ADI1 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (179 aa) |
| | ASAH2 | Neutral ceramidase. (780 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | ELOVL2 | Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (296 aa) |
| | EDN1 | Endothelin 1. (211 aa) |
| | HACD2 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (161 aa) |
| | ACSM3 | Acyl-CoA synthetase medium chain family member 3. (586 aa) |
| | ACSM1 | Acyl-CoA synthetase medium chain family member 1. (577 aa) |
| | ACSM2B | Uncharacterized protein. (577 aa) |
| | ACSM5 | Acyl-CoA synthetase medium chain family member 5. (582 aa) |
| | PSAT1 | Phosphoserine aminotransferase. (370 aa) |
| | BCAT1 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (391 aa) |
| | CBS | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (510 aa) |
| | SHMT1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (410 aa) |
| | PLA2G10 | Phospholipase A(2). (165 aa) |
| | ALDH1A1 | Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (501 aa) |
| | TBXAS1 | Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (534 aa) |
| | LTC4S | Leukotriene C4 synthase. (150 aa) |
| | PLA2G4F | Phospholipase A2. (853 aa) |
| | PCBD1 | Pterin-4 alpha-carbinolamine dehydratase 1. (104 aa) |
| | MGLL | Monoglyceride lipase. (339 aa) |
| | CARNS1 | Carnosine synthase 1. (950 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (464 aa) |
| | CYP27A1 | Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (531 aa) |
| | GSTP1 | Glutathione S-transferase pi 1. (383 aa) |
| | ABAT | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa) |
| | LIPI | Lipase I. (415 aa) |
| | AKR1D1 | Aldo-keto reductase family 1 member D1. (326 aa) |
| | PYCR3 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (286 aa) |
| | PECR | Peroxisomal trans-2-enoyl-CoA reductase. (303 aa) |
| | PLP1 | Proteolipid protein 1. (277 aa) |
| | KMO | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (486 aa) |
| | CPS1 | Carbamoyl-phosphate synthase 1. (1504 aa) |
| | HSD17B8 | Hydroxysteroid 17-beta dehydrogenase 8. (257 aa) |
| | ABHD1 | Abhydrolase domain containing 1. (411 aa) |
| | HACD4 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (195 aa) |
| | CAD | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2225 aa) |
| | MTAP | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (283 aa) |
| | OXSM | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (460 aa) |
| | MTR | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1264 aa) |
| | ACSBG2 | Acyl-CoA synthetase bubblegum family member 2. (639 aa) |
| | GLUD1 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (558 aa) |
| | ACSM4 | Acyl-CoA synthetase medium chain family member 4. (580 aa) |
| | XBP1 | X-box binding protein 1. (261 aa) |
| | GATM | Glycine amidinotransferase. (423 aa) |
| | CYP46A1 | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (500 aa) |
| | AASS | Aminoadipate-semialdehyde synthase. (925 aa) |
| | UPB1 | Beta-ureidopropionase 1. (386 aa) |
| | GATD1 | Glutamine amidotransferase like class 1 domain containing 1. (220 aa) |
| | ENSCSAP00000006952 | Uncharacterized protein. (564 aa) |
| | GGT5 | Gamma-glutamyltransferase 5. (588 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (674 aa) |
