STRINGSTRING
XBP1 XBP1 GPER1 GPER1 S1PR2 S1PR2 JUN JUN S1PR1 S1PR1 HTR1B HTR1B ENSCSAP00000017683 ENSCSAP00000017683 ENSCSAP00000017599 ENSCSAP00000017599 P2RY6 P2RY6 HES5 HES5 CTNNBIP1 CTNNBIP1 MFN2 MFN2 LDLRAP1 LDLRAP1 NPR1 NPR1 IL6R IL6R MEF2D MEF2D PHB PHB DDR2 DDR2 IL18 IL18 PTGIR PTGIR CYBA CYBA NPY5R NPY5R APOE APOE IGF1 IGF1 TGFB1 TGFB1 ITGB3 ITGB3 ERN1 ERN1 GNA13 GNA13 SMPD3 SMPD3 FRS2 FRS2 IFNG IFNG ZNF143 ZNF143 FGFR2 FGFR2 EREG EREG NDRG4 NDRG4 CX3CL1 CX3CL1 ENSCSAP00000001444 ENSCSAP00000001444 PDCD4 PDCD4 MMP2 MMP2 XRCC6 XRCC6 RPS6KB1 RPS6KB1 NOTCH3 NOTCH3 ENSCSAP00000002584 ENSCSAP00000002584 PDGFB PDGFB VIPR2 VIPR2 NPPC NPPC NF1 NF1 CNN1 CNN1 NOS3 NOS3 IRAK4 IRAK4 IRAK1 IRAK1 PTEN PTEN PRKG1 PRKG1 ID2 ID2 THBS1 THBS1 SF1 SF1 DNMT1 DNMT1 EDN1 EDN1 EFEMP2 EFEMP2 HMOX1 HMOX1 APLN APLN CDKN1B CDKN1B APOD APOD IGFBP5 IGFBP5 ADAMTS1 ADAMTS1 XRCC5 XRCC5 MYOCD MYOCD ADIPOQ ADIPOQ TGFBR2 TGFBR2 BMPR1A BMPR1A AKT1 AKT1 FOXJ2 FOXJ2 CCN4 CCN4 PPARD PPARD TRIB1 TRIB1 CDKN1A CDKN1A NOX1 NOX1 BMPR2 BMPR2 NR4A3 NR4A3 FOXP1 FOXP1 PDGFRB PDGFRB TGFB3 TGFB3 STAT1 STAT1 IL12A IL12A ALOX12 ALOX12 CALCRL CALCRL RBPMS2 RBPMS2 SOD2 SOD2 ELANE ELANE HBEGF HBEGF PIK3CA PIK3CA TLR4 TLR4 PTGS2 PTGS2 BMP2 BMP2 VIP VIP RBM10 RBM10 SRC SRC SERPINF2 SERPINF2 IL6 IL6 MNAT1 MNAT1 MMP9 MMP9 MEF2C MEF2C BMP4 BMP4 PRKDC PRKDC IL10 IL10 DBH DBH CCDC142 CCDC142 IGFBP3 IGFBP3 TACR1 TACR1 GJA1 GJA1 PPARGC1A PPARGC1A NDRG2 NDRG2 ITGA2 ITGA2 MAP3K5 MAP3K5 CTNNB1 CTNNB1 TNFAIP3 TNFAIP3 IGF1R IGF1R NPR3 NPR3 TERT TERT GNA12 GNA12 FGF9 FGF9 ELN ELN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XBP1X-box binding protein 1. (261 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
ENSCSAP00000017683Prohibitin. (272 aa)
ENSCSAP00000017599annotation not available (271 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (320 aa)
NPR1Guanylate cyclase. (1270 aa)
IL6RInterleukin 6 receptor. (443 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
PHBProhibitin. (272 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
PTGIRProstaglandin I2 receptor. (387 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
NPY5RNeuropeptide Y receptor Y5. (287 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
IGF1Insulin like growth factor 1. (159 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
GNA13G protein subunit alpha 13. (377 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
ZNF143Zinc finger protein 143. (638 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
EREGEpiregulin. (171 aa)
NDRG4NDRG family member 4. (391 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (402 aa)
ENSCSAP00000001444HMG box domain-containing protein. (377 aa)
PDCD4Programmed cell death 4. (469 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
XRCC6X-ray repair cross complementing 6. (609 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
NOTCH3Notch receptor 3. (1980 aa)
ENSCSAP00000002584Prohibitin. (259 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
VIPR2Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (438 aa)
NPPCNatriuretic peptide C. (126 aa)
NF1Neurofibromin 1. (2849 aa)
CNN1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (297 aa)
NOS3Nitric oxide synthase 3. (867 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (686 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PRKG1Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (471 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
THBS1Thrombospondin 1. (1170 aa)
SF1Splicing factor 1. (548 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1616 aa)
EDN1Endothelin 1. (211 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
HMOX1Heme oxygenase 1. (288 aa)
APLNApelin. (77 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
APODApolipoprotein D. (189 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
MYOCDMyocardin. (986 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (275 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FOXJ2Forkhead box J2. (574 aa)
CCN4Cellular communication network factor 4. (336 aa)
PPARDPeroxisome proliferator activated receptor delta. (372 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
NOX1NADPH oxidase 1. (564 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
FOXP1Fork-head domain-containing protein. (677 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (472 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (217 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (263 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (572 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
VIPVasoactive intestinal peptide. (170 aa)
RBM10RNA binding motif protein 10. (995 aa)
SRCTyrosine-protein kinase. (633 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (495 aa)
IL6Interleukin 6. (212 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
MEF2CMyocyte enhancer factor 2C. (446 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4131 aa)
IL10Interleukin 10. (178 aa)
DBHDopamine beta-hydroxylase. (597 aa)
CCDC142Coiled-coil domain containing 142. (750 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
NDRG2NDRG family member 2. (357 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1219 aa)
CTNNB1Catenin beta 1. (781 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
NPR3Natriuretic peptide receptor 3. (541 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
GNA12G protein subunit alpha 12. (305 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ELNUncharacterized protein. (68 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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