STRINGSTRING
DBX1 DBX1 FKBP8 FKBP8 SUFU SUFU NKX2-2 NKX2-2 PRRX1 PRRX1 DLL1 DLL1 FEZF2 FEZF2 PTF1A PTF1A EYA1 EYA1 HOXD10 HOXD10 ISL2 ISL2 DLX2 DLX2 DLX1 DLX1 BMP4 BMP4 GLI3 GLI3 FOXA1 FOXA1 NKX2-1 NKX2-1 PROX1 PROX1 TBR1 TBR1 LHX3 LHX3 NRG1 NRG1 NOTCH1 NOTCH1 GLI2 GLI2 ISL1 ISL1 CTNNB1 CTNNB1 ZNF521 ZNF521 GSX1 GSX1 SMAD4 SMAD4 FOXN4 FOXN4 DMRTA2 DMRTA2 ATOH1 ATOH1 OLIG3 OLIG3 OLIG1 OLIG1 OLIG2 OLIG2 ASCL1 ASCL1 EPOP EPOP FOXG1 FOXG1 GSX2 GSX2 PAX6 PAX6 HOXC10 HOXC10 LBX1 LBX1 NOTCH3 NOTCH3 WNT1 WNT1 MNX1 MNX1 SHH SHH GBX1 GBX1 MYT1L MYT1L ID2 ID2 DLL4 DLL4 IHH IHH FEV FEV GATA2 GATA2 DMRT3 DMRT3 EHMT2 EHMT2 JAG2 JAG2 TLX3 TLX3 BCL11B BCL11B TGFBR1 TGFBR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DBX1Developing brain homeobox 1. (344 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
NKX2-2NK2 homeobox 2. (273 aa)
PRRX1Paired related homeobox 1. (217 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
FEZF2FEZ family zinc finger 2. (458 aa)
PTF1APancreas associated transcription factor 1a. (329 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (586 aa)
HOXD10Homeobox D10. (340 aa)
ISL2ISL LIM homeobox 2. (359 aa)
DLX2Distal-less homeobox 2. (329 aa)
DLX1Distal-less homeobox 1. (255 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GLI3GLI family zinc finger 3. (1459 aa)
FOXA1Forkhead box A1. (470 aa)
NKX2-1NK2 homeobox 1. (371 aa)
PROX1Prospero homeobox 1. (737 aa)
TBR1T-box brain transcription factor 1. (682 aa)
LHX3LIM homeobox 3. (402 aa)
NRG1Neuregulin 1. (467 aa)
NOTCH1Notch receptor 1. (2555 aa)
GLI2GLI family zinc finger 2. (1554 aa)
ISL1ISL LIM homeobox 1. (349 aa)
CTNNB1Catenin beta 1. (781 aa)
ZNF521Zinc finger protein 521. (1311 aa)
GSX1GS homeobox 1. (264 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FOXN4Forkhead box N4. (517 aa)
DMRTA2DMRT like family A2. (538 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
OLIG3Oligodendrocyte transcription factor 3. (273 aa)
OLIG1Oligodendrocyte transcription factor 1. (271 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (239 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
FOXG1Forkhead box G1. (490 aa)
GSX2GS homeobox 2. (304 aa)
PAX6Paired box 6. (436 aa)
HOXC10Homeobox C10. (342 aa)
LBX1Ladybird homeobox 1. (281 aa)
NOTCH3Notch receptor 3. (1980 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
MNX1Motor neuron and pancreas homeobox 1. (401 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
GBX1Gastrulation brain homeobox 1. (434 aa)
MYT1LMyelin transcription factor 1 like. (1012 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
FEVFEV transcription factor, ETS family member. (238 aa)
GATA2GATA binding protein 2. (397 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1197 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1245 aa)
TLX3T cell leukemia homeobox 3. (291 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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