STRINGSTRING
TAZ TAZ BMP4 BMP4 MEF2C MEF2C ATG5 ATG5 BVES BVES SCN5A SCN5A CHD7 CHD7 TNNI1 TNNI1 TNNT2 TNNT2 ENG ENG MSC MSC VWA5B2 VWA5B2 BMP2 BMP2 TNNC1 TNNC1 HEY1 HEY1 BMP5 BMP5 WNT8A WNT8A NPRL3 NPRL3 TTN TTN WNT5A WNT5A MYLK2 MYLK2 NEBL NEBL C10orf113 C10orf113 SLC8A1 SLC8A1 SHOX2 SHOX2 ALDH1A2 ALDH1A2 ADAMTS9 ADAMTS9 ZFPM2 ZFPM2 PDGFRB PDGFRB SRF SRF DIPK2A DIPK2A KDM6B KDM6B TGFBR1 TGFBR1 ASB2 ASB2 WNT2 WNT2 HAND1 HAND1 CAV3 CAV3 SIRT6 SIRT6 SGCD SGCD EGLN1 EGLN1 MYO18B MYO18B RARB RARB ACTN2 ACTN2 BMPR1A BMPR1A RYR2 RYR2 NKX2-5 NKX2-5 HNRNPU HNRNPU MAP2K4 MAP2K4 MYOCD MYOCD CXADR CXADR PLEC PLEC MAML1 MAML1 FOXH1 FOXH1 MYH11 MYH11 OBSL1 OBSL1 HEG1 HEG1 DLL4 DLL4 JARID2 JARID2 ZIC3 ZIC3 DSP DSP IFT20 IFT20 PKP2 PKP2 PTEN PTEN ARID2 ARID2 ANKRD1 ANKRD1 CBY1 CBY1 TBX2 TBX2 MYBPC3 MYBPC3 CACNA1G CACNA1G IRX3 IRX3 WT1 WT1 HOPX HOPX NRAP NRAP CSRP3 CSRP3 SGCB SGCB MAPK11 MAPK11 NDRG4 NDRG4 FGFR2 FGFR2 PDLIM5 PDLIM5 TENM4 TENM4 GREM1 GREM1 GJA5 GJA5 FOXC1 FOXC1 GJC1 GJC1 PLN PLN LRRC10 LRRC10 GJB6 GJB6 FOXC2 FOXC2 S1PR1 S1PR1 NOG NOG MTOR MTOR NPPA NPPA NPPB NPPB VWA5B1 VWA5B1 SLC9A1 SLC9A1 ZMPSTE24 ZMPSTE24 TGFBR3 TGFBR3 COL11A1 COL11A1 NOTCH2 NOTCH2 TNNI3 TNNI3 LMNA LMNA TBX3 TBX3 TBX5 TBX5 VWA5A VWA5A PRMT1 PRMT1 MYL2 MYL2 MED1 MED1 TCAP TCAP RARA RARA SORBS2 SORBS2 ZFPM1 ZFPM1 PPP1R13L PPP1R13L ENSCSAP00000014858 ENSCSAP00000014858 EDNRA EDNRA SMAD1 SMAD1 TGFB1 TGFB1 ALPK2 ALPK2 SMAD4 SMAD4 MYL10 MYL10 FGF9 FGF9 SGCG SGCG SMAD7 SMAD7 FHOD3 FHOD3 DSG2 DSG2 GATA6 GATA6 ENSCSAP00000013468 ENSCSAP00000013468 TBX18 TBX18 ALPK3 ALPK3 AKAP13 AKAP13 MESP1 MESP1 FHL2 FHL2 GATA4 GATA4 MEF2A MEF2A ISL1 ISL1 WNT3A WNT3A HEY2 HEY2 NKX2-6 NKX2-6 GJA1 GJA1 MYL3 MYL3 GATA5 GATA5 NEB NEB ADRA1A ADRA1A MYH6 MYH6 MYH7 MYH7 ACVR1 ACVR1 NOTCH1 NOTCH1 NRG1 NRG1 TGFB2 TGFB2 PTCD2 PTCD2 MYL7 MYL7 PROX1 PROX1 BMP7 BMP7 XIRP2 XIRP2 LRP2 LRP2 SAV1 SAV1 TSC1 TSC1 BMP10 BMP10 TBX20 TBX20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (262 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MEF2CMyocyte enhancer factor 2C. (446 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
BVESBlood vessel epicardial substance. (360 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1881 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
TNNI1Troponin I1, slow skeletal type. (183 aa)
TNNT2Troponin T2, cardiac type. (302 aa)
ENGEndoglin. (658 aa)
MSCMusculin. (206 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1255 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
TTNTitin. (32000 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
MYLK2Myosin light chain kinase 2. (595 aa)
NEBLNebulette. (716 aa)
C10orf113Chromosome 10 open reading frame 113. (155 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (632 aa)
SHOX2Short stature homeobox 2. (331 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1764 aa)
ZFPM2Zinc finger protein, FOG family member 2. (940 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
SRFSerum response factor. (508 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
KDM6BLysine demethylase 6B. (1640 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (635 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SIRT6Sirtuin 6. (355 aa)
SGCDSarcoglycan delta. (224 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2208 aa)
RARBRetinoic acid receptor beta. (448 aa)
ACTN2Actinin alpha 2. (894 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RYR2Ryanodine receptor 2. (4906 aa)
NKX2-5NK2 homeobox 5. (324 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (363 aa)
MYOCDMyocardin. (986 aa)
CXADRCXADR Ig-like cell adhesion molecule. (352 aa)
PLECPlectin. (4605 aa)
MAML1Mastermind like transcriptional coactivator 1. (790 aa)
FOXH1Forkhead box H1. (365 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1953 aa)
OBSL1Obscurin like 1. (1896 aa)
HEG1Heart development protein with EGF like domains 1. (1323 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1246 aa)
ZIC3Zic family member 3. (466 aa)
DSPDesmoplakin. (2871 aa)
IFT20Intraflagellar transport 20. (163 aa)
PKP2Plakophilin 2. (837 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ARID2AT-rich interaction domain 2. (1687 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
CBY1Chibby family member 1, beta catenin antagonist. (126 aa)
TBX2T-box transcription factor 2. (588 aa)
MYBPC3Myosin binding protein C, cardiac. (1266 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2186 aa)
IRX3Iroquois homeobox 3. (416 aa)
WT1WT1 transcription factor. (320 aa)
HOPXHomeobox domain-containing protein. (73 aa)
NRAPNebulin related anchoring protein. (1042 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
SGCBSarcoglycan beta. (297 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
NDRG4NDRG family member 4. (391 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
PDLIM5PDZ and LIM domain 5. (546 aa)
TENM4Teneurin transmembrane protein 4. (2605 aa)
GREM1Gremlin. (184 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
FOXC1Forkhead box C1. (552 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
LRRC10Leucine rich repeat containing 10. (279 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
FOXC2Forkhead box C2. (501 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
NPPANatriuretic peptide A. (153 aa)
NPPBNatriuretic peptide B. (134 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1219 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
COL11A1Collagen type XI alpha 1 chain. (1806 aa)
NOTCH2Notch receptor 2. (2471 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (663 aa)
TBX3T-box transcription factor 3. (723 aa)
TBX5T-box transcription factor 5. (518 aa)
VWA5AVon Willebrand factor A domain containing 5A. (700 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (306 aa)
MYL2Myosin light chain 2. (166 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
TCAPTitin-cap. (167 aa)
RARARetinoic acid receptor alpha. (462 aa)
SORBS2Sorbin and SH3 domain containing 2. (1524 aa)
ZFPM1Zinc finger protein, FOG family member 1. (992 aa)
PPP1R13LUncharacterized protein. (518 aa)
ENSCSAP00000014858Uncharacterized protein. (451 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ALPK2Alpha kinase 2. (2166 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MYL10Myosin light chain 10. (136 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SGCGSarcoglycan gamma. (291 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
FHOD3Formin homology 2 domain containing 3. (1622 aa)
DSG2Desmoglein 2. (1118 aa)
GATA6GATA binding protein 6. (595 aa)
ENSCSAP00000013468Uncharacterized protein. (1924 aa)
TBX18T-box transcription factor 18. (607 aa)
ALPK3Alpha kinase 3. (1701 aa)
AKAP13A-kinase anchoring protein 13. (2854 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
FHL2Four and a half LIM domains 2. (279 aa)
GATA4GATA binding protein 4. (442 aa)
MEF2AMyocyte enhancer factor 2A. (503 aa)
ISL1ISL LIM homeobox 1. (349 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
NKX2-6NK2 homeobox 6. (301 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
MYL3Myosin light chain 3. (197 aa)
GATA5GATA binding protein 5. (366 aa)
NEBNebulin. (5297 aa)
ADRA1AAdrenoceptor alpha 1A. (425 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1942 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1501 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
NOTCH1Notch receptor 1. (2555 aa)
NRG1Neuregulin 1. (467 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
PTCD2Pentatricopeptide repeat domain 2. (383 aa)
MYL7Myosin light chain 7. (175 aa)
PROX1Prospero homeobox 1. (737 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
XIRP2Xin actin binding repeat containing 2. (3378 aa)
LRP2LDL receptor related protein 2. (3861 aa)
SAV1Salvador family WW domain containing protein 1. (385 aa)
TSC1TSC complex subunit 1. (1164 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
TBX20T-box transcription factor 20. (447 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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