STRINGSTRING
MKS1 MKS1 FGF2 FGF2 WNT9B WNT9B PAK1 PAK1 EGF EGF LEF1 LEF1 GNA13 GNA13 ESRP2 ESRP2 PKD2 PKD2 DCHS1 DCHS1 FGFR2 FGFR2 AREG AREG KDR KDR TIMELESS TIMELESS CELSR1 CELSR1 WT1 WT1 TMEM59L TMEM59L SALL1 SALL1 FGF8 FGF8 BTRC BTRC PAX2 PAX2 TBX2 TBX2 HNF1B HNF1B WNT1 WNT1 GBX2 GBX2 PTCH1 PTCH1 SHH SHH VDR VDR CASR CASR ENSCSAP00000003756 ENSCSAP00000003756 GREB1 GREB1 EDN1 EDN1 DLL4 DLL4 KRAS KRAS GDF7 GDF7 DDR1 DDR1 IHH IHH PPP1CA PPP1CA WNT6 WNT6 DLG1 DLG1 LRP5 LRP5 HS3ST3B1 HS3ST3B1 HS3ST3A1 HS3ST3A1 PLXND1 PLXND1 DLG5 DLG5 NOTCH4 NOTCH4 TGFBR2 TGFBR2 GDF2 GDF2 PHB2 PHB2 PBX1 PBX1 EXT1 EXT1 MET MET PKD1 PKD1 GZF1 GZF1 CITED1 CITED1 NRP1 NRP1 SRF SRF RSPO2 RSPO2 AR AR PGF PGF SEMA3E SEMA3E FGF1 FGF1 WNT5A WNT5A PKHD1 PKHD1 PKHD1-2 PKHD1-2 PLEKHH1 PLEKHH1 BMP2 BMP2 RDH10 RDH10 SRC SRC EYA1 EYA1 ENG ENG PML PML KDM5B KDM5B SIX1 SIX1 ESR1 ESR1 HOXA5 HOXA5 HOXA11 HOXA11 HOXD11 HOXD11 BMP4 BMP4 PPP3R1 PPP3R1 TBX20 TBX20 DAG1 DAG1 CTSH CTSH GLI3 GLI3 FOXA1 FOXA1 BMP7 BMP7 NKX2-1 NKX2-1 CTSZ CTSZ LAMA5 LAMA5 NFATC4 NFATC4 NOTCH1 NOTCH1 ACVR1 ACVR1 NKX3-1 NKX3-1 MMP14 MMP14 ENSCSAP00000012589 ENSCSAP00000012589 SLIT2 SLIT2 GLI2 GLI2 TCF21 TCF21 FGF10 FGF10 CTNNB1 CTNNB1 GDNF GDNF ENSCSAP00000013048 ENSCSAP00000013048 CSMD1 CSMD1 ADAMTS16 ADAMTS16 COL4A1 COL4A1 ENSCSAP00000013601 ENSCSAP00000013601 GREB1L GREB1L SMAD4 SMAD4 BCL2 BCL2 TGFB1 TGFB1 HHIP HHIP EDNRA EDNRA SFRP2 SFRP2 YAP1 YAP1 FOXF1 FOXF1 RASIP1 RASIP1 MED1 MED1 TBX3 TBX3 RBM15 RBM15 CSF1 CSF1 TIE1 TIE1 CSMD2 CSMD2 CLIC4 CLIC4 WNT4 WNT4 EPHA2 EPHA2 CTNNBIP1 CTNNBIP1 SPRY1 SPRY1 FOXC2 FOXC2 SPRY2 SPRY2 NRARP NRARP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MKS1MKS transition zone complex subunit 1. (559 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
GNA13G protein subunit alpha 13. (377 aa)
ESRP2Epithelial splicing regulatory protein 2. (715 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (859 aa)
DCHS1Dachsous cadherin-related 1. (3296 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
AREGAmphiregulin. (252 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
TIMELESSTimeless circadian regulator. (1208 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3017 aa)
WT1WT1 transcription factor. (320 aa)
TMEM59LTransmembrane protein 59 like. (343 aa)
SALL1Spalt like transcription factor 1. (1321 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
PAX2Paired box 2. (261 aa)
TBX2T-box transcription factor 2. (588 aa)
HNF1BHNF1 homeobox B. (557 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
PTCH1Patched 1. (1452 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
VDRVitamin D receptor. (434 aa)
CASRCalcium sensing receptor. (882 aa)
ENSCSAP00000003756Uncharacterized protein. (400 aa)
GREB1Uncharacterized protein. (1418 aa)
EDN1Endothelin 1. (211 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GDF7Growth differentiation factor 7. (447 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
DLG1Uncharacterized protein; Belongs to the MAGUK family. (800 aa)
LRP5LDL receptor related protein 5. (1451 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
PLXND1Plexin D1. (1833 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1900 aa)
NOTCH4Notch receptor 4. (1994 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
GDF2Growth differentiation factor 2. (429 aa)
PHB2Prohibitin. (288 aa)
PBX1PBX homeobox 1. (301 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (420 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1381 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (3853 aa)
GZF1GDNF inducible zinc finger protein 1. (712 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SRFSerum response factor. (508 aa)
RSPO2R-spondin 2. (243 aa)
ARAndrogen receptor. (900 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (715 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (2535 aa)
PKHD1-2Uncharacterized protein. (139 aa)
PLEKHH1Pleckstrin homology, MyTH4 and FERM domain containing H1. (1364 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SRCTyrosine-protein kinase. (633 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (586 aa)
ENGEndoglin. (658 aa)
PMLPromyelocytic leukemia. (819 aa)
KDM5BLysine demethylase 5B. (1544 aa)
SIX1SIX homeobox 1. (284 aa)
ESR1Estrogen receptor 1. (487 aa)
HOXA5Homeobox A5. (381 aa)
HOXA11Homeobox A11. (310 aa)
HOXD11Homeobox D11. (338 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PPP3R1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
TBX20T-box transcription factor 20. (447 aa)
DAG1Dystroglycan 1. (894 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
GLI3GLI family zinc finger 3. (1459 aa)
FOXA1Forkhead box A1. (470 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
NKX2-1NK2 homeobox 1. (371 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
NOTCH1Notch receptor 1. (2555 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
NKX3-1NK3 homeobox 1. (232 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
ENSCSAP00000012589LRRNT domain-containing protein. (132 aa)
SLIT2Slit guidance ligand 2. (1332 aa)
GLI2GLI family zinc finger 2. (1554 aa)
TCF21Transcription factor 21. (179 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CTNNB1Catenin beta 1. (781 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
ENSCSAP00000013048Uncharacterized protein. (152 aa)
CSMD1Uncharacterized protein. (1618 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (889 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
ENSCSAP00000013601Uncharacterized protein. (637 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1873 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HHIPHedgehog interacting protein. (682 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
YAP1Yes associated protein 1. (508 aa)
FOXF1Forkhead box F1. (354 aa)
RASIP1Ras interacting protein 1. (1022 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
TBX3T-box transcription factor 3. (723 aa)
RBM15RNA binding motif protein 15. (976 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (560 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
CSMD2CUB and Sushi multiple domains 2. (3463 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
EPHA2EPH receptor A2. (1033 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
FOXC2Forkhead box C2. (501 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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