STRINGSTRING
WNT11 WNT11 KITLG KITLG PITX2 PITX2 ALX1 ALX1 LEF1 LEF1 DDX5 DDX5 SOX9 SOX9 ENSCSAP00000000740 ENSCSAP00000000740 FGFR2 FGFR2 NOLC1 NOLC1 FGF8 FGF8 SEMA4G SEMA4G PAX2 PAX2 MAPK3 MAPK3 GBX2 GBX2 SHH SHH CYP26C1 CYP26C1 DDX17 DDX17 HTR2B HTR2B FLNA FLNA SOX10 SOX10 RPS7 RPS7 GSK3B GSK3B FOXF2 FOXF2 SEMA4D SEMA4D ROCK2 ROCK2 SEMA5B SEMA5B EDN1 EDN1 OSR1 OSR1 TGFBR3L TGFBR3L WNT10A WNT10A ENSCSAP00000004881 ENSCSAP00000004881 LRP6 LRP6 FN1 FN1 DLG5 DLG5 FGF19 FGF19 NOTCH4 NOTCH4 ERBB4 ERBB4 ENSCSAP00000005731 ENSCSAP00000005731 EOMES EOMES BMPR1A BMPR1A NRTN NRTN SMO SMO NRP2 NRP2 SEMA6B SEMA6B WNT16 WNT16 HAS2 HAS2 GSC GSC EXT1 EXT1 WNT2 WNT2 RET RET ANXA6 ANXA6 TGFBR1 TGFBR1 NRP1 NRP1 WWTR1 WWTR1 OVOL2 OVOL2 TCOF1 TCOF1 CUL7 CUL7 KBTBD8 KBTBD8 TBX1 TBX1 EFNB1 EFNB1 SOX8 SOX8 SEMA3C SEMA3C HGF HGF ALDH1A2 ALDH1A2 STAT1 STAT1 SEMA3E SEMA3E SEMA3A SEMA3A SEMA3D SEMA3D FRZB FRZB TASOR TASOR WNT5A WNT5A AKNA AKNA OTUD5 OTUD5 WNT8A WNT8A SIX2 SIX2 HEY1 HEY1 SEMA3G SEMA3G BMP2 BMP2 RDH10 RDH10 MAPK1 MAPK1 JAG1 JAG1 ENG ENG FAM83D FAM83D HIF1A HIF1A RTN4 RTN4 ENSCSAP00000010227 ENSCSAP00000010227 SEMA7A SEMA7A KLHL12 KLHL12 RFLNB RFLNB SEMA3B SEMA3B SEMA3F SEMA3F ENSCSAP00000010623 ENSCSAP00000010623 FAM172A FAM172A SEMA6A SEMA6A MEF2C MEF2C SNAI2 SNAI2 BMP4 BMP4 PPP3R1 PPP3R1 TBX20 TBX20 SNAI1 SNAI1 SFRP1 SFRP1 FBXL17 FBXL17 ZFP64 ZFP64 ENSCSAP00000011447 ENSCSAP00000011447 FGFR1 FGFR1 BMP7 BMP7 EDN3 EDN3 OLFM1 OLFM1 TGFB2 TGFB2 LOXL3 LOXL3 SEMA4F SEMA4F NRG1 NRG1 LAMA5 LAMA5 NOTCH1 NOTCH1 ACVR1 ACVR1 LOXL2 LOXL2 MSX1 MSX1 HEY2 HEY2 TAPT1 TAPT1 EPB41L5 EPB41L5 TCF21 TCF21 ISL1 ISL1 FGF10 FGF10 POLR1B POLR1B CTNNB1 CTNNB1 GDNF GDNF RANBP3L RANBP3L PHOX2B PHOX2B SEMA4B SEMA4B SEMA4C SEMA4C SEMA5A SEMA5A PDCD6 PDCD6 EDNRB EDNRB ROCK1 ROCK1 RADIL RADIL CDH2 CDH2 SMAD4 SMAD4 BCL2 BCL2 TGFB1 TGFB1 EDNRA EDNRA HAND2 HAND2 DACT3 DACT3 CORO1C CORO1C ENSCSAP00000015417 ENSCSAP00000015417 TBX3 TBX3 SEMA4A SEMA4A EFNA1 EFNA1 ADAM15 ADAM15 S100A4 S100A4 SEMA6C SEMA6C TRIM28 TRIM28 TGFBR3 TGFBR3 HEYL HEYL PEF1 PEF1 PHACTR4 PHACTR4 WNT4 WNT4 NOG NOG TMEM100 TMEM100 ENSCSAP00000017521 ENSCSAP00000017521 SPRY1 SPRY1 SOX11 SOX11 CITED2 CITED2 AMER1 AMER1 FOXC2 FOXC2 FOXC1 FOXC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
PITX2Homeobox protein. (325 aa)
ALX1ALX homeobox 1. (327 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
SOX9SRY-box transcription factor 9. (509 aa)
ENSCSAP00000000740Uncharacterized protein. (88 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (714 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (810 aa)
PAX2Paired box 2. (261 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (650 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
FLNAFilamin A. (2639 aa)
SOX10SRY-box transcription factor 10. (236 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
FOXF2Forkhead box F2. (443 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
SEMA5BSemaphorin 5B. (1152 aa)
EDN1Endothelin 1. (211 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (314 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
ENSCSAP00000004881RRM domain-containing protein. (364 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
FN1Fibronectin 1. (2265 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1900 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
NOTCH4Notch receptor 4. (1994 aa)
ERBB4Protein kinase domain-containing protein. (622 aa)
ENSCSAP00000005731Protein kinase domain-containing protein. (479 aa)
EOMESEomesodermin. (419 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NRTNNeurturin. (197 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (901 aa)
SEMA6BSema domain-containing protein; Belongs to the semaphorin family. (374 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
HAS2Hyaluronan synthase 2. (552 aa)
GSCGoosecoid homeobox. (259 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (420 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1099 aa)
ANXA6Annexin. (676 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1524 aa)
CUL7Cullin 7; Belongs to the cullin family. (1697 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (575 aa)
TBX1T-box transcription factor 1. (490 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
SOX8SRY-box transcription factor 8. (446 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (715 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (746 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
FRZBFrizzled related protein. (325 aa)
TASORTranscription activation suppressor. (1514 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
AKNAAT-hook transcription factor. (1437 aa)
OTUD5OTU deubiquitinase 5. (376 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SIX2SIX homeobox 2. (290 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (782 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
ENGEndoglin. (658 aa)
FAM83DFamily with sequence similarity 83 member D. (419 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
RTN4Reticulon. (199 aa)
ENSCSAP00000010227Uncharacterized protein. (225 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (501 aa)
KLHL12BTB domain-containing protein. (527 aa)
RFLNBRefilin B. (216 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (748 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (754 aa)
ENSCSAP0000001062340S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (196 aa)
FAM172AFamily with sequence similarity 172 member A. (450 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1043 aa)
MEF2CMyocyte enhancer factor 2C. (446 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PPP3R1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
TBX20T-box transcription factor 20. (447 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FBXL17F-box and leucine rich repeat protein 17. (583 aa)
ZFP64ZFP64 zinc finger protein. (681 aa)
ENSCSAP00000011447Uncharacterized protein. (637 aa)
FGFR1Fibroblast growth factor receptor. (830 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
EDN3Endothelin 3. (230 aa)
OLFM1Olfactomedin 1. (328 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
NRG1Neuregulin 1. (467 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
NOTCH1Notch receptor 1. (2555 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
LOXL2Lysyl oxidase like 2. (774 aa)
MSX1Msh homeobox 1. (303 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
TAPT1Transmembrane anterior posterior transformation 1. (674 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (699 aa)
TCF21Transcription factor 21. (179 aa)
ISL1ISL LIM homeobox 1. (349 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
CTNNB1Catenin beta 1. (781 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
RANBP3LRAN binding protein 3 like. (465 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (836 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
SEMA5ASemaphorin 5A. (1074 aa)
PDCD6Programmed cell death 6. (136 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (442 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
RADILRap associating with DIL domain. (1100 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
DACT3Dishevelled binding antagonist of beta catenin 3. (634 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (483 aa)
ENSCSAP00000015417Uncharacterized protein. (269 aa)
TBX3T-box transcription factor 3. (723 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (810 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
ADAM15ADAM metallopeptidase domain 15. (754 aa)
S100A4Protein S100; Belongs to the S-100 family. (101 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (931 aa)
TRIM28Tripartite motif containing 28. (834 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
PEF1Penta-EF-hand domain containing 1. (283 aa)
PHACTR4Phosphatase and actin regulator. (685 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TMEM100Transmembrane protein 100. (134 aa)
ENSCSAP0000001752140S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
SOX11Transcription factor SOX. (441 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
AMER1APC membrane recruitment protein 1. (1134 aa)
FOXC2Forkhead box C2. (501 aa)
FOXC1Forkhead box C1. (552 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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