STRINGSTRING
HTR2B HTR2B FGFBP1 FGFBP1 NRARP NRARP C5AR2 C5AR2 GPBAR1 GPBAR1 CCR3 CCR3 FZD7 FZD7 FOXE3 FOXE3 JUN JUN SOX11 SOX11 NOG NOG PIK3CD PIK3CD F3 F3 PROK1 PROK1 ZNF304 ZNF304 NRAS NRAS ZNF580 ZNF580 NOTCH2 NOTCH2 CRNN CRNN IQGAP3 IQGAP3 EMC10 EMC10 RPTOR RPTOR JAML JAML MED1 MED1 ERBB2 ERBB2 IL18 IL18 C5AR1 C5AR1 PRKD2 PRKD2 CYBA CYBA VEGFC VEGFC STAT5A STAT5A MMP12 MMP12 STAT3 STAT3 YAP1 YAP1 IGF1 IGF1 TGFB1 TGFB1 GRN GRN PDPK1 PDPK1 CCL26 CCL26 CCL24 CCL24 ECM1 ECM1 FGF9 FGF9 ARNT ARNT PDX1 PDX1 HRH4 HRH4 IRS2 IRS2 SEMA5A SEMA5A RICTOR RICTOR TNFAIP3 TNFAIP3 CTNNB1 CTNNB1 FGF10 FGF10 ARG1 ARG1 WNT3A WNT3A EGR3 EGR3 NKX2-6 NKX2-6 EGFR EGFR TGM1 TGM1 HLX HLX REG3A REG3A NOTCH1 NOTCH1 REG1A REG1A REG1B REG1B TACR1 TACR1 PRKD1 PRKD1 ZNF703 ZNF703 PROX1 PROX1 VASH2 VASH2 FGFR1 FGFR1 AGGF1 AGGF1 THBS4 THBS4 TGFA TGFA SFRP1 SFRP1 VEGFD VEGFD IL10 IL10 MST1 MST1 BMP4 BMP4 WDR48 WDR48 SCN5A SCN5A CYP7B1 CYP7B1 HYAL1 HYAL1 KDM5B KDM5B ENSCSAP00000010227 ENSCSAP00000010227 RTN4 RTN4 HIF1A HIF1A SRSF6 SRSF6 PLCG1 PLCG1 PPP1R16B PPP1R16B EYA1 EYA1 VIP VIP BMP2 BMP2 MAP2K5 MAP2K5 BMP5 BMP5 DLX5 DLX5 PKHD1-2 PKHD1-2 PKHD1 PKHD1 ITGA4 ITGA4 WNT5A WNT5A GHSR GHSR ID1 ID1 MTA3 MTA3 LAMC1 LAMC1 RUNX2 RUNX2 FGF1 FGF1 OSR2 OSR2 PGF PGF SPINK1 SPINK1 VEGFA VEGFA AR AR TBX1 TBX1 JCAD JCAD AGTR1 AGTR1 NRP1 NRP1 NR4A3 NR4A3 TGFBR1 TGFBR1 HRAS HRAS CXCL12 CXCL12 WNT2 WNT2 ATP7A ATP7A SIRT6 SIRT6 HAS2 HAS2 FGF7 FGF7 LRG1 LRG1 BMPR2 BMPR2 MYDGF MYDGF NRP2 NRP2 MYC MYC GHRL GHRL GDF2 GDF2 XBP1 XBP1 SMO SMO B4GALT1 B4GALT1 BTK BTK IGF2 IGF2 TEK TEK AKT1 AKT1 BMPR1A BMPR1A NKX2-5 NKX2-5 WNT7A WNT7A ENSCSAP00000005586 ENSCSAP00000005586 AKT3 AKT3 CCND1 CCND1 TP63 TP63 CLDN1 CLDN1 PTN PTN GATA2 GATA2 IHH IHH APLN APLN NODAL NODAL HMOX1 HMOX1 PTPRN PTPRN RESP18 RESP18 FLT4 FLT4 OSR1 OSR1 ST8SIA1 ST8SIA1 SCG2 SCG2 SIRT1 SIRT1 BMP6 BMP6 RREB1 RREB1 BAD BAD ADAM17 ADAM17 VEGFB VEGFB PLXNB3 PLXNB3 NF1 NF1 SHH SHH PDGFB PDGFB APLNR APLNR ACVRL1 ACVRL1 NR4A1 NR4A1 MDK MDK PAX2 PAX2 STXBP4 STXBP4 NME1 NME1 SP1 SP1 LACRT LACRT NOD2 NOD2 ENSCSAP00000001444 ENSCSAP00000001444 KDR KDR SAAL1 SAAL1 ODAM ODAM EPGN EPGN AREG AREG FGFR2 FGFR2 AGAP2 AGAP2 HTRA1 HTRA1 HPN HPN HMX2 HMX2 SOX9 SOX9 PRKCA PRKCA CDH3 CDH3 ESRP2 ESRP2 EGF EGF ITGB3 ITGB3 HSF4 HSF4 FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
C5AR2Complement component 5a receptor 2. (337 aa)
GPBAR1G protein-coupled bile acid receptor 1. (330 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (355 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FOXE3Forkhead box E3. (316 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
SOX11Transcription factor SOX. (441 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
F3Coagulation factor III, tissue factor. (245 aa)
PROK1Prokineticin 1. (105 aa)
ZNF304Zinc finger protein 304. (659 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ZNF580Zinc finger protein 580. (172 aa)
NOTCH2Notch receptor 2. (2471 aa)
CRNNCornulin. (495 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1632 aa)
EMC10ER membrane protein complex subunit 10. (262 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
JAMLUncharacterized protein. (394 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (406 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
STAT5ASignal transducer and activator of transcription. (798 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
YAP1Yes associated protein 1. (508 aa)
IGF1Insulin like growth factor 1. (159 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GRNGranulin precursor. (605 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
CCL26C-C motif chemokine. (94 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
ECM1Extracellular matrix protein 1. (540 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
HRH4Histamine receptor H4; Belongs to the G-protein coupled receptor 1 family. (339 aa)
IRS2Insulin receptor substrate 2. (906 aa)
SEMA5ASemaphorin 5A. (1074 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1679 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CTNNB1Catenin beta 1. (781 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ARG1Arginase. (322 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
EGR3Early growth response 3. (387 aa)
NKX2-6NK2 homeobox 6. (301 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
TGM1Transglutaminase 1. (820 aa)
HLXH2.0 like homeobox. (494 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
NOTCH1Notch receptor 1. (2555 aa)
REG1ARegenerating family member 1 alpha. (166 aa)
REG1BRegenerating family member 1 beta. (166 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
ZNF703Zinc finger protein 703. (590 aa)
PROX1Prospero homeobox 1. (737 aa)
VASH2Vasohibin 2. (355 aa)
FGFR1Fibroblast growth factor receptor. (830 aa)
AGGF1Uncharacterized protein. (710 aa)
THBS4Thrombospondin 4. (870 aa)
TGFATransforming growth factor alpha. (158 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
IL10Interleukin 10. (178 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
WDR48WD repeat domain 48. (677 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1881 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (436 aa)
HYAL1Hyaluronidase. (450 aa)
KDM5BLysine demethylase 5B. (1544 aa)
ENSCSAP00000010227Uncharacterized protein. (225 aa)
RTN4Reticulon. (199 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
SRSF6Serine and arginine rich splicing factor 6. (343 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (568 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (586 aa)
VIPVasoactive intestinal peptide. (170 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
DLX5Distal-less homeobox 5. (289 aa)
PKHD1-2Uncharacterized protein. (139 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (2535 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
LAMC1Laminin subunit gamma 1. (1573 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (450 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
ARAndrogen receptor. (900 aa)
TBX1T-box transcription factor 1. (490 aa)
JCADJunctional cadherin 5 associated. (1357 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
SIRT6Sirtuin 6. (355 aa)
HAS2Hyaluronan synthase 2. (552 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
MYDGFMyeloid derived growth factor. (96 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (901 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
GHRLGhrelin and obestatin prepropeptide. (141 aa)
GDF2Growth differentiation factor 2. (429 aa)
XBP1X-box binding protein 1. (261 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
BTKTyrosine-protein kinase. (497 aa)
IGF2Insulin like growth factor 2. (236 aa)
TEKTEK receptor tyrosine kinase. (1123 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NKX2-5NK2 homeobox 5. (324 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ENSCSAP00000005586Uncharacterized protein. (163 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (500 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
PTNPleiotrophin. (168 aa)
GATA2GATA binding protein 2. (397 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
APLNApelin. (77 aa)
NODALNodal growth differentiation factor. (347 aa)
HMOX1Heme oxygenase 1. (288 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
RESP18Regulated endocrine specific protein 18. (177 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
SCG2Secretogranin II. (577 aa)
SIRT1Sirtuin 1. (743 aa)
BMP6Bone morphogenetic protein 6. (433 aa)
RREB1Ras responsive element binding protein 1. (1742 aa)
BADBCL2 associated agonist of cell death. (167 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
PLXNB3Plexin B3. (1909 aa)
NF1Neurofibromin 1. (2849 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
APLNRApelin receptor APJ; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (651 aa)
MDKUncharacterized protein. (159 aa)
PAX2Paired box 2. (261 aa)
STXBP4Syntaxin binding protein 4. (498 aa)
NME1Nucleoside diphosphate kinase. (152 aa)
SP1Sp1 transcription factor. (786 aa)
LACRTLacritin. (137 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1036 aa)
ENSCSAP00000001444HMG box domain-containing protein. (377 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
SAAL1Serum amyloid A like 1. (473 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
EPGNEpithelial mitogen. (154 aa)
AREGAmphiregulin. (252 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1195 aa)
HTRA1HtrA serine peptidase 1. (524 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
HMX2H6 family homeobox 2. (273 aa)
SOX9SRY-box transcription factor 9. (509 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
ESRP2Epithelial splicing regulatory protein 2. (715 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
HSF4Heat shock transcription factor 4. (494 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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