STRINGSTRING
FGF2 FGF2 HSF4 HSF4 ITGB3 ITGB3 EGF EGF ESRP2 ESRP2 CDH3 CDH3 PRKCA PRKCA SOX9 SOX9 HMX2 HMX2 HPN HPN HTRA1 HTRA1 AGAP2 AGAP2 FGFR2 FGFR2 AREG AREG EPGN EPGN ODAM ODAM SAAL1 SAAL1 KDR KDR ENSCSAP00000001444 ENSCSAP00000001444 NOD2 NOD2 LACRT LACRT SP1 SP1 NME1 NME1 STXBP4 STXBP4 PAX2 PAX2 MDK MDK NR4A1 NR4A1 ACVRL1 ACVRL1 APLNR APLNR PDGFB PDGFB SHH SHH NF1 NF1 HTR2B HTR2B PLXNB3 PLXNB3 VEGFB VEGFB ADAM17 ADAM17 BAD BAD RREB1 RREB1 BMP6 BMP6 SIRT1 SIRT1 SCG2 SCG2 ST8SIA1 ST8SIA1 OSR1 OSR1 FLT4 FLT4 RESP18 RESP18 PTPRN PTPRN HMOX1 HMOX1 NODAL NODAL APLN APLN IHH IHH GATA2 GATA2 PTN PTN CLDN1 CLDN1 TP63 TP63 CCND1 CCND1 AKT3 AKT3 ENSCSAP00000005586 ENSCSAP00000005586 WNT7A WNT7A NKX2-5 NKX2-5 BMPR1A BMPR1A AKT1 AKT1 TEK TEK IGF2 IGF2 BTK BTK B4GALT1 B4GALT1 SMO SMO XBP1 XBP1 GDF2 GDF2 GHRL GHRL MYC MYC NRP2 NRP2 MYDGF MYDGF BMPR2 BMPR2 NRARP NRARP LRG1 LRG1 FGF7 FGF7 HAS2 HAS2 SIRT6 SIRT6 ATP7A ATP7A WNT2 WNT2 CXCL12 CXCL12 HRAS HRAS TGFBR1 TGFBR1 NR4A3 NR4A3 NRP1 NRP1 AGTR1 AGTR1 JCAD JCAD TBX1 TBX1 AR AR VEGFA VEGFA SPINK1 SPINK1 FGFBP1 FGFBP1 PGF PGF OSR2 OSR2 FGF1 FGF1 RUNX2 RUNX2 LAMC1 LAMC1 MTA3 MTA3 ID1 ID1 GHSR GHSR WNT5A WNT5A ITGA4 ITGA4 PKHD1 PKHD1 PKHD1-2 PKHD1-2 DLX5 DLX5 BMP5 BMP5 MAP2K5 MAP2K5 BMP2 BMP2 VIP VIP EYA1 EYA1 PPP1R16B PPP1R16B PLCG1 PLCG1 SRSF6 SRSF6 HIF1A HIF1A RTN4 RTN4 ENSCSAP00000010227 ENSCSAP00000010227 KDM5B KDM5B HYAL1 HYAL1 CYP7B1 CYP7B1 SCN5A SCN5A WDR48 WDR48 BMP4 BMP4 MST1 MST1 IL10 IL10 VEGFD VEGFD SFRP1 SFRP1 TGFA TGFA THBS4 THBS4 AGGF1 AGGF1 FGFR1 FGFR1 VASH2 VASH2 PROX1 PROX1 ZNF703 ZNF703 PRKD1 PRKD1 TACR1 TACR1 REG1B REG1B REG1A REG1A NOTCH1 NOTCH1 REG3A REG3A HLX HLX TGM1 TGM1 EGFR EGFR NKX2-6 NKX2-6 EGR3 EGR3 WNT3A WNT3A ARG1 ARG1 FGF10 FGF10 CTNNB1 CTNNB1 TNFAIP3 TNFAIP3 RICTOR RICTOR SEMA5A SEMA5A IRS2 IRS2 HRH4 HRH4 PDX1 PDX1 ARNT ARNT FGF9 FGF9 ECM1 ECM1 CCL24 CCL24 CCL26 CCL26 PDPK1 PDPK1 GRN GRN TGFB1 TGFB1 IGF1 IGF1 YAP1 YAP1 STAT3 STAT3 MMP12 MMP12 STAT5A STAT5A VEGFC VEGFC CYBA CYBA PRKD2 PRKD2 C5AR1 C5AR1 IL18 IL18 ERBB2 ERBB2 MED1 MED1 JAML JAML RPTOR RPTOR EMC10 EMC10 IQGAP3 IQGAP3 CRNN CRNN NOTCH2 NOTCH2 ZNF580 ZNF580 NRAS NRAS ZNF304 ZNF304 PROK1 PROK1 F3 F3 PIK3CD PIK3CD NOG NOG SOX11 SOX11 JUN JUN FOXE3 FOXE3 FZD7 FZD7 CCR3 CCR3 GPBAR1 GPBAR1 C5AR2 C5AR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
HSF4Heat shock transcription factor 4. (494 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
ESRP2Epithelial splicing regulatory protein 2. (715 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
SOX9SRY-box transcription factor 9. (509 aa)
HMX2H6 family homeobox 2. (273 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
HTRA1HtrA serine peptidase 1. (524 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1195 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
AREGAmphiregulin. (252 aa)
EPGNEpithelial mitogen. (154 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
SAAL1Serum amyloid A like 1. (473 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ENSCSAP00000001444HMG box domain-containing protein. (377 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1036 aa)
LACRTLacritin. (137 aa)
SP1Sp1 transcription factor. (786 aa)
NME1Nucleoside diphosphate kinase. (152 aa)
STXBP4Syntaxin binding protein 4. (498 aa)
PAX2Paired box 2. (261 aa)
MDKUncharacterized protein. (159 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (651 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
APLNRApelin receptor APJ; Belongs to the G-protein coupled receptor 1 family. (380 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
NF1Neurofibromin 1. (2849 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
PLXNB3Plexin B3. (1909 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
BADBCL2 associated agonist of cell death. (167 aa)
RREB1Ras responsive element binding protein 1. (1742 aa)
BMP6Bone morphogenetic protein 6. (433 aa)
SIRT1Sirtuin 1. (743 aa)
SCG2Secretogranin II. (577 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
RESP18Regulated endocrine specific protein 18. (177 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
HMOX1Heme oxygenase 1. (288 aa)
NODALNodal growth differentiation factor. (347 aa)
APLNApelin. (77 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
GATA2GATA binding protein 2. (397 aa)
PTNPleiotrophin. (168 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (500 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
ENSCSAP00000005586Uncharacterized protein. (163 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
NKX2-5NK2 homeobox 5. (324 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TEKTEK receptor tyrosine kinase. (1123 aa)
IGF2Insulin like growth factor 2. (236 aa)
BTKTyrosine-protein kinase. (497 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
XBP1X-box binding protein 1. (261 aa)
GDF2Growth differentiation factor 2. (429 aa)
GHRLGhrelin and obestatin prepropeptide. (141 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (901 aa)
MYDGFMyeloid derived growth factor. (96 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
HAS2Hyaluronan synthase 2. (552 aa)
SIRT6Sirtuin 6. (355 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
JCADJunctional cadherin 5 associated. (1357 aa)
TBX1T-box transcription factor 1. (490 aa)
ARAndrogen receptor. (900 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (450 aa)
LAMC1Laminin subunit gamma 1. (1573 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (2535 aa)
PKHD1-2Uncharacterized protein. (139 aa)
DLX5Distal-less homeobox 5. (289 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
VIPVasoactive intestinal peptide. (170 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (586 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (568 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
SRSF6Serine and arginine rich splicing factor 6. (343 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
RTN4Reticulon. (199 aa)
ENSCSAP00000010227Uncharacterized protein. (225 aa)
KDM5BLysine demethylase 5B. (1544 aa)
HYAL1Hyaluronidase. (450 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (436 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1881 aa)
WDR48WD repeat domain 48. (677 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
IL10Interleukin 10. (178 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
TGFATransforming growth factor alpha. (158 aa)
THBS4Thrombospondin 4. (870 aa)
AGGF1Uncharacterized protein. (710 aa)
FGFR1Fibroblast growth factor receptor. (830 aa)
VASH2Vasohibin 2. (355 aa)
PROX1Prospero homeobox 1. (737 aa)
ZNF703Zinc finger protein 703. (590 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
REG1BRegenerating family member 1 beta. (166 aa)
REG1ARegenerating family member 1 alpha. (166 aa)
NOTCH1Notch receptor 1. (2555 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
HLXH2.0 like homeobox. (494 aa)
TGM1Transglutaminase 1. (820 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
NKX2-6NK2 homeobox 6. (301 aa)
EGR3Early growth response 3. (387 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ARG1Arginase. (322 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CTNNB1Catenin beta 1. (781 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1679 aa)
SEMA5ASemaphorin 5A. (1074 aa)
IRS2Insulin receptor substrate 2. (906 aa)
HRH4Histamine receptor H4; Belongs to the G-protein coupled receptor 1 family. (339 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ECM1Extracellular matrix protein 1. (540 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
CCL26C-C motif chemokine. (94 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
GRNGranulin precursor. (605 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IGF1Insulin like growth factor 1. (159 aa)
YAP1Yes associated protein 1. (508 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
STAT5ASignal transducer and activator of transcription. (798 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (406 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
JAMLUncharacterized protein. (394 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
EMC10ER membrane protein complex subunit 10. (262 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1632 aa)
CRNNCornulin. (495 aa)
NOTCH2Notch receptor 2. (2471 aa)
ZNF580Zinc finger protein 580. (172 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ZNF304Zinc finger protein 304. (659 aa)
PROK1Prokineticin 1. (105 aa)
F3Coagulation factor III, tissue factor. (245 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SOX11Transcription factor SOX. (441 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
FOXE3Forkhead box E3. (316 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (355 aa)
GPBAR1G protein-coupled bile acid receptor 1. (330 aa)
C5AR2Complement component 5a receptor 2. (337 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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