STRINGSTRING
ACVRL1 ACVRL1 TERF2IP TERF2IP RPS3 RPS3 ACD ACD RNF169 RNF169 TERF2 TERF2 HELB HELB ENSCSAP00000000740 ENSCSAP00000000740 RECQL5 RECQL5 TEN1 TEN1 TIMELESS TIMELESS TENT4B TENT4B NAT10 NAT10 ANKLE1 ANKLE1 MCRS1 MCRS1 SLX1 SLX1 LIG3 LIG3 TNKS2 TNKS2 NPPC NPPC ANKRD1 ANKRD1 OTUB1 OTUB1 TRIP12 TRIP12 POLQ POLQ MEN1 MEN1 GMNN GMNN ERCC4 ERCC4 NRM NRM RMI2 RMI2 FLCN FLCN HSF1 HSF1 CDAN1 CDAN1 GMNC GMNC NUDT16L1 NUDT16L1 SMARCAL1 SMARCAL1 XRCC5 XRCC5 H1-8 H1-8 BCL6 BCL6 TP53BP1 TP53BP1 CYREN CYREN ADIPOQ ADIPOQ HNRNPU HNRNPU RADX RADX WAPL WAPL DONSON DONSON SHLD2 SHLD2 SLX4 SLX4 GDF2 GDF2 POT1 POT1 CDKN1A CDKN1A ERCC6 ERCC6 BMPR2 BMPR2 OGG1 OGG1 CTC1 CTC1 OTUB2 OTUB2 ENSCSAP00000007206 ENSCSAP00000007206 XRN1 XRN1 ATR ATR TP53 TP53 ENSCSAP00000007796 ENSCSAP00000007796 DNAJC2 DNAJC2 UBR5 UBR5 GNL3L GNL3L NDFIP1 NDFIP1 PIF1 PIF1 TSPYL2 TSPYL2 FOXP3 FOXP3 TIPIN TIPIN GATA3 GATA3 SHLD1 SHLD1 FBXO5 FBXO5 MSH2 MSH2 MSH6 MSH6 TERF1 TERF1 FBH1 FBH1 SRC SRC NIBAN2 NIBAN2 SMG6 SMG6 PARP3 PARP3 CGAS CGAS GTPBP4 GTPBP4 PML PML MLH1 MLH1 KLHL15 KLHL15 XRCC4 XRCC4 DCP2 DCP2 TTF1 TTF1 MSH3 MSH3 FANCB FANCB KCNK2 KCNK2 ENSCSAP00000011749 ENSCSAP00000011749 TINF2 TINF2 RIF1 RIF1 PARP1 PARP1 ZRANB3 ZRANB3 MCIDAS MCIDAS HNRNPC HNRNPC GZMA GZMA TNKS TNKS PINX1 PINX1 PDS5A PDS5A BLM BLM SMCHD1 SMCHD1 DACH1 DACH1 THOC1 THOC1 BRCA2 BRCA2 PARPBP PARPBP ERCC1 ERCC1 HCRT HCRT ATM ATM CDT1 CDT1 CDC6 CDC6 CHEK1 CHEK1 UBQLN4 UBQLN4 TRIM28 TRIM28 AUNIP AUNIP MAD2L2 MAD2L2 EXOSC10 EXOSC10 DFFA DFFA HNRNPCL1 HNRNPCL1 ZNF830 ZNF830 S100A11 S100A11 H1-10 H1-10 MAGEF1 MAGEF1 H1-5 H1-5 H1-3 H1-3 H1-4 H1-4 H1-6 H1-6 H1-2 H1-2 H1-1 H1-1 ENSCSAP00000018936 ENSCSAP00000018936 ENSCSAP00000018998 ENSCSAP00000018998 ENSCSAP00000019103 ENSCSAP00000019103
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
TERF2IPTERF2 interacting protein. (400 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (537 aa)
RNF169Ring finger protein 169. (486 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (500 aa)
HELBDNA helicase B. (1087 aa)
ENSCSAP00000000740Uncharacterized protein. (88 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
TEN1Uncharacterized protein. (94 aa)
TIMELESSTimeless circadian regulator. (1208 aa)
TENT4BTerminal nucleotidyltransferase 4B. (635 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
ANKLE1Ankyrin repeat and LEM domain containing 1. (615 aa)
MCRS1Microspherule protein 1. (462 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
LIG3DNA ligase. (1009 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
NPPCNatriuretic peptide C. (126 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
OTUB1Ubiquitin thioesterase. (280 aa)
TRIP12Thyroid hormone receptor interactor 12. (2067 aa)
POLQDNA polymerase theta. (2729 aa)
MEN1Menin 1. (610 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
NRMNurim. (262 aa)
RMI2RecQ mediated genome instability 2. (147 aa)
FLCNFolliculin. (579 aa)
HSF1Heat shock transcription factor 1. (529 aa)
CDAN1Codanin 1. (1228 aa)
GMNCGeminin coiled-coil domain containing. (334 aa)
NUDT16L1Nudix hydrolase 16 like 1. (225 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
H1-8H1 histone family member O oocyte specific. (346 aa)
BCL6BCL6 transcription repressor. (708 aa)
TP53BP1Tumor protein p53 binding protein 1. (1977 aa)
CYRENCell cycle regulator of NHEJ. (159 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (275 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
RADXRPA1 related single stranded DNA binding protein, X-linked. (855 aa)
WAPLWAPL cohesin release factor. (1190 aa)
DONSONDownstream neighbor of SON. (564 aa)
SHLD2FAM35_C domain-containing protein. (856 aa)
SLX4Uncharacterized protein. (929 aa)
GDF2Growth differentiation factor 2. (429 aa)
POT1Protection of telomeres 1. (634 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1494 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
OGG18-oxoguanine DNA glycosylase. (405 aa)
CTC1CST telomere replication complex component 1. (1209 aa)
OTUB2OTU deubiquitinase, ubiquitin aldehyde binding 2. (243 aa)
ENSCSAP00000007206Uncharacterized protein. (119 aa)
XRN15'-3' exoribonuclease 1. (1707 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ENSCSAP00000007796H15 domain-containing protein. (342 aa)
DNAJC2DnaJ heat shock protein family (Hsp40) member C2. (621 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2793 aa)
GNL3LG protein nucleolar 3 like. (472 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
TSPYL2TSPY like 2; Belongs to the nucleosome assembly protein (NAP) family. (696 aa)
FOXP3Forkhead box P3. (358 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa)
GATA3GATA binding protein 3. (443 aa)
SHLD1Shieldin complex subunit 1. (205 aa)
FBXO5F-box protein 5. (448 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (440 aa)
FBH1F-box DNA helicase 1. (971 aa)
SRCTyrosine-protein kinase. (633 aa)
NIBAN2Niban apoptosis regulator 2. (746 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1419 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
CGASCyclic GMP-AMP synthase. (526 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
PMLPromyelocytic leukemia. (819 aa)
MLH1MutL homolog 1. (756 aa)
KLHL15Kelch like family member 15. (604 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
DCP2Decapping mRNA 2. (420 aa)
TTF1Transcription termination factor 1. (916 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1125 aa)
FANCBFA complementation group B. (859 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (411 aa)
ENSCSAP00000011749G-patch domain-containing protein. (330 aa)
TINF2TERF1 interacting nuclear factor 2. (424 aa)
RIF1Replication timing regulatory factor 1. (2465 aa)
PARP1Poly(ADP-ribose) polymerase 1. (709 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1016 aa)
MCIDASMulticiliate differentiation and DNA synthesis associated cell cycle protein. (385 aa)
HNRNPCHeterogeneous nuclear ribonucleoprotein C (C1/C2). (293 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (262 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (328 aa)
PDS5APDS5 cohesin associated factor A. (1293 aa)
BLMBLM RecQ like helicase. (1423 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2005 aa)
DACH1Dachshund family transcription factor 1. (454 aa)
THOC1THO complex 1. (657 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
PARPBPPARP1 binding protein. (581 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
CDT1Chromatin licensing and DNA replication factor 1. (551 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
CHEK1Checkpoint kinase 1. (749 aa)
UBQLN4Ubiquitin-like domain-containing protein. (308 aa)
TRIM28Tripartite motif containing 28. (834 aa)
AUNIPAurora kinase A and ninein interacting protein. (351 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
EXOSC10Exosome component 10. (884 aa)
DFFADNA fragmentation factor subunit alpha. (331 aa)
HNRNPCL1RRM domain-containing protein. (293 aa)
ZNF830Zinc finger protein 830. (372 aa)
S100A11Protein S100; Belongs to the S-100 family. (105 aa)
H1-10H1 histone family member X. (213 aa)
MAGEF1MAGE family member F1. (308 aa)
H1-5Histone cluster 1 H1 family member b. (226 aa)
H1-3Histone cluster 1 H1 family member d. (221 aa)
H1-4Histone cluster 1 H1 family member e. (219 aa)
H1-6Histone cluster 1 H1 family member t. (208 aa)
H1-2Histone cluster 1 H1 family member c. (213 aa)
H1-1Histone cluster 1 H1 family member a. (215 aa)
ENSCSAP00000018936Protein S100; Belongs to the S-100 family. (105 aa)
ENSCSAP00000018998Protein S100; Belongs to the S-100 family. (101 aa)
ENSCSAP00000019103EF-hand domain-containing protein; Belongs to the S-100 family. (104 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (18%) [HD]