STRINGSTRING
SMAD1 SMAD1 IGF1 IGF1 DMPK DMPK KAT2A KAT2A PIEZO1 PIEZO1 MAMSTR MAMSTR YBX1 YBX1 MTOR MTOR TRIM32 TRIM32 ZBED6 ZBED6 FZD7 FZD7 TMEM119 TMEM119 BHLHA15 BHLHA15 GPER1 GPER1 NFATC1 NFATC1 TGFB1 TGFB1 HDAC5 HDAC5 GSK3A GSK3A EDN1 EDN1 RBM24 RBM24 OLFM2 OLFM2 BHLHE41 BHLHE41 EFEMP2 EFEMP2 ACTN3 ACTN3 RBM4B RBM4B MAML1 MAML1 MYOCD MYOCD NKX2-5 NKX2-5 TCF23 TCF23 BMPR1A BMPR1A NID1 NID1 IGF2 IGF2 XBP1 XBP1 MAPK14 MAPK14 PI16 PI16 SETD3 SETD3 BMPR2 BMPR2 CAMK1 CAMK1 CAV3 CAV3 CCN3 CCN3 FOXO4 FOXO4 FOXP1 FOXP1 SRF SRF LMOD3 LMOD3 ZEB1 ZEB1 TBX1 TBX1 DLL1 DLL1 SHOX2 SHOX2 RBPMS2 RBPMS2 SOD2 SOD2 LAMC1 LAMC1 PTBP1 PTBP1 RGS2 RGS2 BMP2 BMP2 HDAC9 HDAC9 ENSCSAP00000009705 ENSCSAP00000009705 ENSCSAP00000009708 ENSCSAP00000009708 NIBAN2 NIBAN2 CDK9 CDK9 ENG ENG MYOG MYOG MEGF10 MEGF10 PRDM6 PRDM6 FBXO22 FBXO22 MEF2C MEF2C PLPP7 PLPP7 BMP4 BMP4 BMP10 BMP10 NFATC2 NFATC2 CYP26B1 CYP26B1 RBM38 RBM38 PROX1 PROX1 CCDC142 CCDC142 AKAP6 AKAP6 NRG1 NRG1 NOTCH1 NOTCH1 MMP14 MMP14 MSX1 MSX1 HEY2 HEY2 SMYD1 SMYD1 CCNT2 CCNT2 WNT3A WNT3A LAMA2 LAMA2 PARP2 PARP2 MESP1 MESP1 AKIRIN2 AKIRIN2 ATP11A ATP11A EFNB2 EFNB2 ENSCSAP00000013601 ENSCSAP00000013601 FGF9 FGF9 SMAD4 SMAD4 BCL2 BCL2 CTDP1 CTDP1 MYF5 MYF5 MYF6 MYF6 NFATC3 NFATC3 ENSCSAP00000000421 ENSCSAP00000000421 FRS2 FRS2 FGFR2 FGFR2 EREG EREG SOX6 SOX6 ANKRD17 ANKRD17 MYOD1 MYOD1 MAPK11 MAPK11 MAPK12 MAPK12 KIT KIT HOPX HOPX PDCD4 PDCD4 PPARA PPARA TARBP2 TARBP2 TRIM72 TRIM72 HDAC4 HDAC4 TOMM70 TOMM70 PDGFB PDGFB SHH SHH G6PD G6PD MECP2 MECP2 EZH2 EZH2 DKK1 DKK1 SUPT6H SUPT6H DNMT1 DNMT1 SIRT1 SIRT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD1Mothers against decapentaplegic homolog. (465 aa)
IGF1Insulin like growth factor 1. (159 aa)
DMPKDM1 protein kinase. (629 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2533 aa)
MAMSTRMEF2 activating motif and SAP domain containing transcriptional regulator. (416 aa)
YBX1Y-box binding protein 1. (255 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
TRIM32Tripartite motif containing 32. (653 aa)
ZBED6Zinc finger BED-type containing 6. (977 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
TMEM119Transmembrane protein 119. (280 aa)
BHLHA15Basic helix-loop-helix family member a15. (194 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
NFATC1Nuclear factor of activated T cells 1. (929 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1155 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
EDN1Endothelin 1. (211 aa)
RBM24RNA binding motif protein 24. (236 aa)
OLFM2Olfactomedin 2. (376 aa)
BHLHE41Basic helix-loop-helix family member e41. (482 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (901 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
MAML1Mastermind like transcriptional coactivator 1. (790 aa)
MYOCDMyocardin. (986 aa)
NKX2-5NK2 homeobox 5. (324 aa)
TCF23Transcription factor 23. (214 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NID1Nidogen 1. (1249 aa)
IGF2Insulin like growth factor 2. (236 aa)
XBP1X-box binding protein 1. (261 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (460 aa)
SETD3Protein-histidine N-methyltransferase. (595 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CCN3Cellular communication network factor 3. (357 aa)
FOXO4Forkhead box O4. (505 aa)
FOXP1Fork-head domain-containing protein. (677 aa)
SRFSerum response factor. (508 aa)
LMOD3Leiomodin 3. (558 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1124 aa)
TBX1T-box transcription factor 1. (490 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
SHOX2Short stature homeobox 2. (331 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (217 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
LAMC1Laminin subunit gamma 1. (1573 aa)
PTBP1Polypyrimidine tract binding protein 1. (556 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (780 aa)
ENSCSAP00000009705Hist_deacetyl domain-containing protein. (114 aa)
ENSCSAP00000009708Hist_deacetyl domain-containing protein. (156 aa)
NIBAN2Niban apoptosis regulator 2. (746 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (488 aa)
ENGEndoglin. (658 aa)
MYOGMyogenin. (249 aa)
MEGF10Multiple EGF like domains 10. (1140 aa)
PRDM6PR/SET domain 6. (597 aa)
FBXO22F-box protein 22. (438 aa)
MEF2CMyocyte enhancer factor 2C. (446 aa)
PLPP7Phospholipid phosphatase 7 (inactive). (271 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
NFATC2Nuclear factor of activated T cells 2. (928 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (459 aa)
RBM38RNA binding motif protein 38. (237 aa)
PROX1Prospero homeobox 1. (737 aa)
CCDC142Coiled-coil domain containing 142. (750 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
NRG1Neuregulin 1. (467 aa)
NOTCH1Notch receptor 1. (2555 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
MSX1Msh homeobox 1. (303 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
SMYD1SET and MYND domain containing 1. (490 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (663 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LAMA2Laminin subunit alpha 2. (3147 aa)
PARP2Poly(ADP-ribose) polymerase 2. (570 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
AKIRIN2Akirin 2. (204 aa)
ATP11APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1134 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
ENSCSAP00000013601Uncharacterized protein. (637 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (864 aa)
MYF5Myogenic factor 5. (255 aa)
MYF6Myogenic factor 6. (241 aa)
NFATC3RHD domain-containing protein. (637 aa)
ENSCSAP00000000421Uncharacterized protein. (398 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
EREGEpiregulin. (171 aa)
SOX6SRY-box transcription factor 6. (466 aa)
ANKRD17Ankyrin repeat domain 17. (2490 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
HOPXHomeobox domain-containing protein. (73 aa)
PDCD4Programmed cell death 4. (469 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
TRIM72Tripartite motif containing 72. (348 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1088 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (608 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (479 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1580 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1616 aa)
SIRT1Sirtuin 1. (743 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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