STRINGSTRING
COMP COMP WNT7B WNT7B CD44 CD44 HOXC4 HOXC4 RARG RARG EXT2 EXT2 MAPK3 MAPK3 WNT10B WNT10B COL2A1 COL2A1 SNORC SNORC NPPC NPPC BGN BGN ESRRA ESRRA BMP6 BMP6 EDN1 EDN1 GPLD1 GPLD1 LTBP3 LTBP3 SOX5 SOX5 OSR1 OSR1 MATN3 MATN3 BBS1 BBS1 MGP MGP IHH IHH SCX SCX RUNX1 RUNX1 CREB3L2 CREB3L2 NFIB NFIB CER1 CER1 BARX2 BARX2 HOXB3 HOXB3 TRPV4 TRPV4 ZBTB16 ZBTB16 THRA THRA RARA RARA CHST11 CHST11 HAND2 HAND2 MMP13 MMP13 SFRP2 SFRP2 SMAD1 SMAD1 TGFB1 TGFB1 MEX3C MEX3C ECM1 ECM1 FGF9 FGF9 RB1 RB1 CNMD CNMD TYMS TYMS TWSG1 TWSG1 UNCX UNCX ARID5A ARID5A ADAMTS12 ADAMTS12 CTNNB1 CTNNB1 CHSY1 CHSY1 CCN2 CCN2 BMP1 BMP1 SLC39A14 SLC39A14 TAPT1 TAPT1 EIF2AK3 EIF2AK3 MSX1 MSX1 CYTL1 CYTL1 STC1 STC1 EVC EVC PTH1R PTH1R FGFR3 FGFR3 BMP7 BMP7 GLI3 GLI3 SNAI1 SNAI1 SULF2 SULF2 BMP4 BMP4 SNAI2 SNAI2 DLX2 DLX2 MEF2C MEF2C IMPAD1 IMPAD1 ATF2 ATF2 HOXD11 HOXD11 HOXD3 HOXD3 HOXA11 HOXA11 HOXA5 HOXA5 HOXA3 HOXA3 HYAL3 HYAL3 HYAL1 HYAL1 HYAL2 HYAL2 HIF1A HIF1A SULF1 SULF1 MKKS MKKS ITGB8 ITGB8 BMP2 BMP2 PITX1 PITX1 TGFBI TGFBI SMAD5 SMAD5 SIX2 SIX2 DDRGK1 DDRGK1 BMP5 BMP5 IL17F IL17F WNT5A WNT5A COL27A1 COL27A1 RUNX2 RUNX2 COL3A1 COL3A1 OSR2 OSR2 IFT80 IFT80 SHOX2 SHOX2 RSPO2 RSPO2 OTOR OTOR WNT5B WNT5B ZEB1 ZEB1 SRF SRF PRRX1 PRRX1 SATB2 SATB2 TRIP11 TRIP11 FGF6 FGF6 PKD1 PKD1 ANXA6 ANXA6 EXT1 EXT1 CCN3 CCN3 HAND1 HAND1 ATP7A ATP7A BMPR2 BMPR2 FGF4 FGF4 GDF5 GDF5 MAPK14 MAPK14 GHRL GHRL GDF2 GDF2 RARB RARB BMPR1A BMPR1A FGF18 FGF18 TGFBR2 TGFBR2 COL11A2 COL11A2 WNT7A WNT7A LOC103243499 LOC103243499 NOG NOG TSKU TSKU HES5 HES5 RUNX3 RUNX3 MATN1 MATN1 ENSCSAP00000016885 ENSCSAP00000016885 ENSCSAP00000016884 ENSCSAP00000016884 ENSCSAP00000016878 ENSCSAP00000016878 ZMPSTE24 ZMPSTE24 CCN1 CCN1 COL11A1 COL11A1 WNT2B WNT2B PBXIP1 PBXIP1 THBS3 THBS3 MEF2D MEF2D SNX19 SNX19 EPYC EPYC MYF5 MYF5 SERPINH1 SERPINH1 CHRDL2 CHRDL2 SMPD3 SMPD3 AXIN2 AXIN2 BMPR1B BMPR1B SOX9 SOX9 ENSCSAP00000000740 ENSCSAP00000000740 SCUBE2 SCUBE2 BMP3 BMP3 SOX6 SOX6 BBS2 BBS2 COL1A1 COL1A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COMPCartilage oligomeric matrix protein. (757 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CD44CD44 molecule (Indian blood group). (699 aa)
HOXC4Homeobox C4. (264 aa)
RARGRetinoic acid receptor gamma. (443 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (751 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
COL2A1Collagen type II alpha 1 chain. (1488 aa)
SNORCSecondary ossification center associated regulator of chondrocyte maturation. (121 aa)
NPPCNatriuretic peptide C. (126 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (368 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
BMP6Bone morphogenetic protein 6. (433 aa)
EDN1Endothelin 1. (211 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (638 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1298 aa)
SOX5SRY-box transcription factor 5. (763 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
MATN3Matrilin 3. (486 aa)
BBS1BBS1 domain-containing protein. (593 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (103 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (456 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
BARX2BARX homeobox 2. (217 aa)
HOXB3Homeobox B3. (431 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (824 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
THRAThyroid hormone receptor alpha. (490 aa)
RARARetinoic acid receptor alpha. (462 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
MMP13Matrix metallopeptidase 13. (471 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MEX3CMex-3 RNA binding family member C. (659 aa)
ECM1Extracellular matrix protein 1. (540 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RB1RB transcriptional corepressor 1. (928 aa)
CNMDChondromodulin. (334 aa)
TYMSThymidylate synthetase. (313 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
UNCXUNC homeobox. (377 aa)
ARID5AAT-rich interaction domain 5A. (593 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
CTNNB1Catenin beta 1. (781 aa)
CHSY1Hexosyltransferase. (711 aa)
CCN2Cellular communication network factor 2. (349 aa)
BMP1Metalloendopeptidase. (986 aa)
SLC39A14Solute carrier family 39 member 14. (342 aa)
TAPT1Transmembrane anterior posterior transformation 1. (674 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (965 aa)
MSX1Msh homeobox 1. (303 aa)
CYTL1Cytokine like 1. (136 aa)
STC1Stanniocalcin 1. (247 aa)
EVCEvC ciliary complex subunit 1. (948 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GLI3GLI family zinc finger 3. (1459 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (950 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
DLX2Distal-less homeobox 2. (329 aa)
MEF2CMyocyte enhancer factor 2C. (446 aa)
IMPAD1Inositol monophosphatase domain containing 1. (359 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
HOXD11Homeobox D11. (338 aa)
HOXD3Homeobox D3. (432 aa)
HOXA11Homeobox A11. (310 aa)
HOXA5Homeobox A5. (381 aa)
HOXA3Homeobox A3. (443 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
HYAL1Hyaluronidase. (450 aa)
HYAL2Hyaluronidase. (473 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
PITX1Homeobox protein. (314 aa)
TGFBITransforming growth factor beta induced. (683 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SIX2SIX homeobox 2. (290 aa)
DDRGK1DDRGK domain containing 1. (312 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
IL17FInterleukin 17F. (163 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
COL27A1Collagen type XXVII alpha 1 chain. (1860 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (450 aa)
COL3A1Collagen type III alpha 1 chain. (878 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
IFT80Intraflagellar transport 80. (768 aa)
SHOX2Short stature homeobox 2. (331 aa)
RSPO2R-spondin 2. (243 aa)
OTOROtoraplin. (128 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1124 aa)
SRFSerum response factor. (508 aa)
PRRX1Paired related homeobox 1. (217 aa)
SATB2DNA-binding protein SATB. (733 aa)
TRIP11Thyroid hormone receptor interactor 11. (1700 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (3853 aa)
ANXA6Annexin. (676 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (420 aa)
CCN3Cellular communication network factor 3. (357 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
GDF5Growth differentiation factor 5. (499 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GHRLGhrelin and obestatin prepropeptide. (141 aa)
GDF2Growth differentiation factor 2. (429 aa)
RARBRetinoic acid receptor beta. (448 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
COL11A2Collagen type XI alpha 2 chain. (1650 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LOC103243499Uncharacterized protein. (251 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
MATN1Matrilin 1. (496 aa)
ENSCSAP00000016885TGFb_propeptide domain-containing protein. (144 aa)
ENSCSAP00000016884TGF_BETA_2 domain-containing protein. (292 aa)
ENSCSAP00000016878TGF_BETA_2 domain-containing protein. (354 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
CCN1Cellular communication network factor 1. (381 aa)
COL11A1Collagen type XI alpha 1 chain. (1806 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (347 aa)
PBXIP1PBX homeobox interacting protein 1. (735 aa)
THBS3Thrombospondin 3. (947 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
SNX19Sorting nexin 19. (992 aa)
EPYCEpiphycan. (322 aa)
MYF5Myogenic factor 5. (255 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (418 aa)
CHRDL2Chordin like 2. (429 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
AXIN2Axin 2. (843 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (536 aa)
SOX9SRY-box transcription factor 9. (509 aa)
ENSCSAP00000000740Uncharacterized protein. (88 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (944 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (474 aa)
SOX6SRY-box transcription factor 6. (466 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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