STRINGSTRING
CACNG2 CACNG2 GRIN2B GRIN2B KMO KMO ADORA2A ADORA2A RELN RELN NLGN1 NLGN1 PTGS2 PTGS2 NLGN2 NLGN2 NRXN1 NRXN1 PTK2B PTK2B RAB3GAP1 RAB3GAP1 GRIN1 GRIN1 GRIN2D GRIN2D NTRK1 NTRK1 CACNG7 CACNG7 CACNG8 CACNG8 CCR2 CCR2 TSHZ3 TSHZ3 TNR TNR CACNG5 CACNG5 CACNG4 CACNG4 NPS NPS SHANK3 SHANK3 CCL2 CCL2 ROR2 ROR2 DTNBP1 DTNBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1402 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (486 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
RELNReelin. (3427 aa)
NLGN1Neuroligin 1. (509 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (572 aa)
NLGN2Neuroligin 2. (836 aa)
NRXN1Neurexin 1. (831 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (989 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1336 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (421 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
TSHZ3Teashirt zinc finger homeobox 3. (1081 aa)
TNRTenascin R. (1034 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (278 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
NPSNeuropeptide S. (89 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1737 aa)
CCL2C-C motif chemokine. (99 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2. (581 aa)
DTNBP1Dystrobrevin binding protein 1. (350 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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