(39 nodes) Type I interferon signaling pathway network (Chlorocebus sabaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

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protein homology

Your Input:
	OAS2	2'-5'-oligoadenylate synthetase 2. (687 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	IRF7	Interferon regulatory factor 7. (506 aa)
	IFI27	Uncharacterized protein. (122 aa)
	IFITM3	Uncharacterized protein. (104 aa)
	STAT1	Signal transducer and activator of transcription. (750 aa)
	MAVS	Mitochondrial antiviral signaling protein. (540 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	TANK	TRAF family member associated NFKB activator. (425 aa)
	IRF3	Interferon regulatory factor 3. (422 aa)
	OAS1	2'-5'-oligoadenylate synthetase 1. (448 aa)
	JAK1	Tyrosine-protein kinase. (1154 aa)
	ENSCSAP00000017361	Uncharacterized protein. (133 aa)
	IFNAR2	Uncharacterized protein. (516 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (571 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	STAT2	Signal transducer and activator of transcription. (851 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (686 aa)
	SP100	SP100 nuclear antigen. (851 aa)
	TYK2	Tyrosine-protein kinase. (1184 aa)
	IFNA8	Interferon alpha 8. (195 aa)
	IFNE	Interferon epsilon. (207 aa)
	IFNK	Interferon kappa. (207 aa)
	ENSCSAP00000017563	Uncharacterized protein. (189 aa)
	ENSCSAP00000017564	Uncharacterized protein. (189 aa)
	IFNA6	Interferon alpha 6. (189 aa)
	IFNA14	Interferon alpha 14. (189 aa)
	ENSCSAP00000017567	Uncharacterized protein. (189 aa)
	ENSCSAP00000017568	Uncharacterized protein. (189 aa)
	ENSCSAP00000017569	Uncharacterized protein. (189 aa)
	IFNW1	Interferon omega 1. (195 aa)
	IFNB1	Interferon beta 1. (187 aa)
	ENSCSAP00000017822	Uncharacterized protein. (133 aa)
	ENSCSAP00000017900	Uncharacterized protein. (133 aa)
	ENSCSAP00000017972	Uncharacterized protein. (122 aa)
	ENSCSAP00000018876	Uncharacterized protein. (133 aa)
	ENSCSAP00000018918	Uncharacterized protein. (133 aa)
	ENSCSAP00000018958	Uncharacterized protein. (125 aa)

Your Current Organism:

Chlorocebus sabaeus

NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSAP00000017563	IFNA14	ENSCSAP00000017563	ENSCSAP00000017566	Uncharacterized protein.	Interferon alpha 14.	0.403
ENSCSAP00000017563	IFNAR1	ENSCSAP00000017563	ENSCSAP00000005998	Uncharacterized protein.	Interferon alpha and beta receptor subunit 1.	0.950
ENSCSAP00000017563	IFNAR2	ENSCSAP00000017563	ENSCSAP00000005985	Uncharacterized protein.	Uncharacterized protein.	0.959
ENSCSAP00000017563	IFNB1	ENSCSAP00000017563	ENSCSAP00000017571	Uncharacterized protein.	Interferon beta 1.	0.526
ENSCSAP00000017563	IRF3	ENSCSAP00000017563	ENSCSAP00000015566	Uncharacterized protein.	Interferon regulatory factor 3.	0.765
ENSCSAP00000017563	IRF7	ENSCSAP00000017563	ENSCSAP00000007052	Uncharacterized protein.	Interferon regulatory factor 7.	0.764
ENSCSAP00000017563	JAK1	ENSCSAP00000017563	ENSCSAP00000016666	Uncharacterized protein.	Tyrosine-protein kinase.	0.791
ENSCSAP00000017563	TYK2	ENSCSAP00000017563	ENSCSAP00000003507	Uncharacterized protein.	Tyrosine-protein kinase.	0.450
ENSCSAP00000017564	IFNA14	ENSCSAP00000017564	ENSCSAP00000017566	Uncharacterized protein.	Interferon alpha 14.	0.402
ENSCSAP00000017564	IFNAR1	ENSCSAP00000017564	ENSCSAP00000005998	Uncharacterized protein.	Interferon alpha and beta receptor subunit 1.	0.950
ENSCSAP00000017564	IFNAR2	ENSCSAP00000017564	ENSCSAP00000005985	Uncharacterized protein.	Uncharacterized protein.	0.959
ENSCSAP00000017564	IFNB1	ENSCSAP00000017564	ENSCSAP00000017571	Uncharacterized protein.	Interferon beta 1.	0.525
ENSCSAP00000017564	IRF3	ENSCSAP00000017564	ENSCSAP00000015566	Uncharacterized protein.	Interferon regulatory factor 3.	0.765
ENSCSAP00000017564	IRF7	ENSCSAP00000017564	ENSCSAP00000007052	Uncharacterized protein.	Interferon regulatory factor 7.	0.764
ENSCSAP00000017564	JAK1	ENSCSAP00000017564	ENSCSAP00000016666	Uncharacterized protein.	Tyrosine-protein kinase.	0.791
ENSCSAP00000017564	TYK2	ENSCSAP00000017564	ENSCSAP00000003507	Uncharacterized protein.	Tyrosine-protein kinase.	0.450
ENSCSAP00000017567	IFNAR1	ENSCSAP00000017567	ENSCSAP00000005998	Uncharacterized protein.	Interferon alpha and beta receptor subunit 1.	0.938
ENSCSAP00000017567	IFNAR2	ENSCSAP00000017567	ENSCSAP00000005985	Uncharacterized protein.	Uncharacterized protein.	0.946
ENSCSAP00000017567	IRF3	ENSCSAP00000017567	ENSCSAP00000015566	Uncharacterized protein.	Interferon regulatory factor 3.	0.698
ENSCSAP00000017567	IRF7	ENSCSAP00000017567	ENSCSAP00000007052	Uncharacterized protein.	Interferon regulatory factor 7.	0.710

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