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DLL4 DLL4 HEG1 HEG1 EFEMP2 EFEMP2 FOXH1 FOXH1 PROX1 PROX1 XIRP2 XIRP2 LRP2 LRP2 BMP10 BMP10 TBX20 TBX20 CHD7 CHD7 TNNI1 TNNI1 TNNT2 TNNT2 ENG ENG BMP2 BMP2 TNNC1 TNNC1 TTN TTN WNT5A WNT5A MYLK2 MYLK2 COL3A1 COL3A1 SHOX2 SHOX2 ZFPM2 ZFPM2 TBX1 TBX1 TGFBR1 TGFBR1 WNT2 WNT2 HAND1 HAND1 EGLN1 EGLN1 BMPR1A BMPR1A RYR2 RYR2 NKX2-5 NKX2-5 HEY2 HEY2 MED1 MED1 MYH6 MYH6 MYH7 MYH7 NOTCH1 NOTCH1 ISL1 ISL1 NRG1 NRG1 TGFB2 TGFB2 PTCD2 PTCD2 SMAD7 SMAD7 MYL10 MYL10 SMAD4 SMAD4 TGFB1 TGFB1 EDNRA EDNRA ZFPM1 ZFPM1 TCAP TCAP MYL3 MYL3 MYL2 MYL2 TNNI3 TNNI3 COL11A1 COL11A1 TGFBR3 TGFBR3 NOG NOG S1PR1 S1PR1 FOXC2 FOXC2 FZD2 FZD2 FOXC1 FOXC1 FZD1 FZD1 MYF5 MYF5 MYF6 MYF6 FGFR2 FGFR2 MYBPC3 MYBPC3 MYLPF MYLPF ANKRD1 ANKRD1 PKP2 PKP2 DSP DSP ADARB1 ADARB1 MYLK MYLK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
HEG1Heart development protein with EGF like domains 1. (1323 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
FOXH1Forkhead box H1. (365 aa)
PROX1Prospero homeobox 1. (737 aa)
XIRP2Xin actin binding repeat containing 2. (3378 aa)
LRP2LDL receptor related protein 2. (3861 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
TBX20T-box transcription factor 20. (447 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
TNNI1Troponin I1, slow skeletal type. (183 aa)
TNNT2Troponin T2, cardiac type. (302 aa)
ENGEndoglin. (658 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
TTNTitin. (32000 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
MYLK2Myosin light chain kinase 2. (595 aa)
COL3A1Collagen type III alpha 1 chain. (878 aa)
SHOX2Short stature homeobox 2. (331 aa)
ZFPM2Zinc finger protein, FOG family member 2. (940 aa)
TBX1T-box transcription factor 1. (490 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RYR2Ryanodine receptor 2. (4906 aa)
NKX2-5NK2 homeobox 5. (324 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1942 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1501 aa)
NOTCH1Notch receptor 1. (2555 aa)
ISL1ISL LIM homeobox 1. (349 aa)
NRG1Neuregulin 1. (467 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
PTCD2Pentatricopeptide repeat domain 2. (383 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
MYL10Myosin light chain 10. (136 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ZFPM1Zinc finger protein, FOG family member 1. (992 aa)
TCAPTitin-cap. (167 aa)
MYL3Myosin light chain 3. (197 aa)
MYL2Myosin light chain 2. (166 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
COL11A1Collagen type XI alpha 1 chain. (1806 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
FOXC2Forkhead box C2. (501 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
FOXC1Forkhead box C1. (552 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa)
MYF5Myogenic factor 5. (255 aa)
MYF6Myogenic factor 6. (241 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
MYBPC3Myosin binding protein C, cardiac. (1266 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (169 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
PKP2Plakophilin 2. (837 aa)
DSPDesmoplakin. (2871 aa)
ADARB1Adenosine deaminase RNA specific B1. (701 aa)
MYLKMyosin light chain kinase. (1914 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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