STRINGSTRING
WNT11 WNT11 NRN1L NRN1L SOX9 SOX9 LLPH LLPH FGFR2 FGFR2 AREG AREG SALL1 SALL1 WNT7B WNT7B RARG RARG LZTS2 LZTS2 SLIT1 SLIT1 TBX2 TBX2 HNF1B HNF1B ALCAM ALCAM SHH SHH CYFIP1 CYFIP1 CDK5 CDK5 PLXNA3 PLXNA3 FMN1 FMN1 EIF2AK4 EIF2AK4 NRN1 NRN1 PAK6 PAK6 SEMA5B SEMA5B EDN1 EDN1 SLC9A6 SLC9A6 ULK2 ULK2 PLXNA1 PLXNA1 DDR1 DDR1 DCX DCX PPP3CB PPP3CB VCL VCL APP APP KIF26B KIF26B SH3GL2 SH3GL2 TGFBR2 TGFBR2 C9orf72 C9orf72 SLIT3 SLIT3 NRP2 NRP2 RAPH1 RAPH1 TMEM108 TMEM108 RYK RYK EXT1 EXT1 NRP1 NRP1 MED12 MED12 PTK7 PTK7 SRF SRF TNN TNN TNR TNR SEMA3A SEMA3A POU4F3 POU4F3 STK11 STK11 FGF1 FGF1 SPAG6 SPAG6 WNT5A WNT5A ITGA4 ITGA4 HDAC6 HDAC6 LHX2 LHX2 JADE2 JADE2 RDH10 RDH10 KDM5B KDM5B SEMA7A SEMA7A ESR1 ESR1 SEMA3F SEMA3F HOXD13 HOXD13 BMP4 BMP4 MST1 MST1 SFRP1 SFRP1 NIN NIN EFNA5 EFNA5 LAMB2 LAMB2 EMX1 EMX1 AURKA AURKA WASF1 WASF1 EDN3 EDN3 MAP1B MAP1B CDH4 CDH4 NOTCH1 NOTCH1 COBL COBL BIN3 BIN3 WNT3A WNT3A ENSCSAP00000012530 ENSCSAP00000012530 SSNA1 SSNA1 ENSCSAP00000012589 ENSCSAP00000012589 SLIT2 SLIT2 EPB41L5 EPB41L5 FGF10 FGF10 CTNNB1 CTNNB1 IQGAP1 IQGAP1 MESP1 MESP1 SEMA5A SEMA5A ENSCSAP00000013468 ENSCSAP00000013468 IMPACT IMPACT SPART SPART DCLK1 DCLK1 RNF6 RNF6 LIMK1 LIMK1 AUTS2 AUTS2 TGFB1 TGFB1 POU4F2 POU4F2 RND2 RND2 EDNRA EDNRA SFRP2 SFRP2 YAP1 YAP1 CADM1 CADM1 MED1 MED1 ULK1 ULK1 TRIM28 TRIM28 CSF1 CSF1 LPAR3 LPAR3 EDN2 EDN2 PRKCZ PRKCZ DVL1 DVL1 SPRY1 SPRY1 S1PR1 S1PR1 SPRY2 SPRY2 FLRT3 FLRT3 NDN NDN FLRT1 FLRT1 BDNF BDNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NRN1LNeuritin 1 like. (106 aa)
SOX9SRY-box transcription factor 9. (509 aa)
LLPHLLP homolog, long-term synaptic facilitation factor. (129 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
AREGAmphiregulin. (252 aa)
SALL1Spalt like transcription factor 1. (1321 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
RARGRetinoic acid receptor gamma. (443 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
SLIT1Slit guidance ligand 1. (1396 aa)
TBX2T-box transcription factor 2. (588 aa)
HNF1BHNF1 homeobox B. (557 aa)
ALCAMActivated leukocyte cell adhesion molecule. (599 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
CDK5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (224 aa)
PLXNA3Plexin A3. (1871 aa)
FMN1Formin 1. (1291 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
NRN1Neuritin 1. (142 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
SEMA5BSemaphorin 5B. (1152 aa)
EDN1Endothelin 1. (211 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (702 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1036 aa)
PLXNA1Plexin A1. (1916 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
DCXDoublecortin. (358 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
VCLVinculin. (1134 aa)
APPAmyloid beta precursor protein. (770 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1660 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (317 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
SLIT3Slit guidance ligand 3. (1320 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (901 aa)
RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1303 aa)
TMEM108Transmembrane protein 108. (575 aa)
RYKReceptor like tyrosine kinase. (609 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (420 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
MED12Mediator complex subunit 12. (2090 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
SRFSerum response factor. (508 aa)
TNNTenascin N. (1299 aa)
TNRTenascin R. (1034 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (746 aa)
POU4F3POU domain protein. (338 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SPAG6Sperm associated antigen 6. (509 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
HDAC6Histone deacetylase 6. (1215 aa)
LHX2LIM homeobox 2. (406 aa)
JADE2Jade family PHD finger 2. (834 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
KDM5BLysine demethylase 5B. (1544 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (501 aa)
ESR1Estrogen receptor 1. (487 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (754 aa)
HOXD13Homeobox D13. (343 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
NINNinein. (2179 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (197 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
EMX1Empty spiracles homeobox 1. (290 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (403 aa)
WASF1WASP family member 1. (559 aa)
EDN3Endothelin 3. (230 aa)
MAP1BMicrotubule associated protein 1B. (2468 aa)
CDH4Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (700 aa)
NOTCH1Notch receptor 1. (2555 aa)
COBLCordon-bleu WH2 repeat protein. (1302 aa)
BIN3Bridging integrator 3. (254 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ENSCSAP00000012530Spatacsin_C domain-containing protein. (308 aa)
SSNA1SS nuclear autoantigen 1. (119 aa)
ENSCSAP00000012589LRRNT domain-containing protein. (132 aa)
SLIT2Slit guidance ligand 2. (1332 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (699 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CTNNB1Catenin beta 1. (781 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
SEMA5ASemaphorin 5A. (1074 aa)
ENSCSAP00000013468Uncharacterized protein. (1924 aa)
IMPACTImpact RWD domain protein. (320 aa)
SPARTSpartin. (666 aa)
DCLK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (487 aa)
RNF6Ring finger protein 6. (685 aa)
LIMK1LIM domain kinase 1. (647 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1015 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
POU4F2POU domain protein. (407 aa)
RND2Rho family GTPase 2. (227 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
YAP1Yes associated protein 1. (508 aa)
CADM1Cell adhesion molecule 1. (323 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1070 aa)
TRIM28Tripartite motif containing 28. (834 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (560 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
EDN2Endothelin 2. (178 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (488 aa)
DVL1Dishevelled segment polarity protein 1. (574 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
NDNNecdin, MAGE family member. (321 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (674 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (247 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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