STRINGSTRING
SMO SMO GREM1 GREM1 GCNT3 GCNT3 AGTR2 AGTR2 GCNT4 GCNT4 SOX4 SOX4 COMMD5 COMMD5 GCNT1 GCNT1 NOG NOG HES5 HES5 CTNNBIP1 CTNNBIP1 WNT4 WNT4 ZMPSTE24 ZMPSTE24 TACSTD2 TACSTD2 HS2ST1 HS2ST1 WNK4 WNK4 BCL2 BCL2 SMAD4 SMAD4 GREB1L GREB1L IRX2 IRX2 IRX1 IRX1 ADAMTS16 ADAMTS16 GDNF GDNF CTNNB1 CTNNB1 AHI1 AHI1 FGF10 FGF10 TCF21 TCF21 LAMA5 LAMA5 ENSCSAP00000011565 ENSCSAP00000011565 BMP7 BMP7 GLI3 GLI3 BMP4 BMP4 HOXD11 HOXD11 HOXA11 HOXA11 SIX1 SIX1 EYA1 EYA1 BMP2 BMP2 GATA3 GATA3 SIX2 SIX2 KLHL3 KLHL3 CALB1 CALB1 ASXL1 ASXL1 FGF1 FGF1 PGF PGF SOX8 SOX8 PDGFRB PDGFRB WWTR1 WWTR1 CITED1 CITED1 GZF1 GZF1 PKD1 PKD1 PBX1 PBX1 ENSCSAP00000005731 ENSCSAP00000005731 ERBB4 ERBB4 KIF26B KIF26B HS3ST3A1 HS3ST3A1 HS3ST3B1 HS3ST3B1 DLG1 DLG1 WNT6 WNT6 OSR1 OSR1 GPC3 GPC3 GREB1 GREB1 ENSCSAP00000003756 ENSCSAP00000003756 LRRK2 LRRK2 FMN1 FMN1 SHH SHH PTCH1 PTCH1 WNT1 WNT1 HNF1B HNF1B PAX2 PAX2 LZTS2 LZTS2 FGF8 FGF8 WNT7B WNT7B SALL1 SALL1 TMEM59L TMEM59L IRX3 IRX3 WT1 WT1 LGR4 LGR4 FOXJ1 FOXJ1 FRAS1 FRAS1 SOX9 SOX9 DCHS1 DCHS1 PKD2 PKD2 PPP3CA PPP3CA WNT11 WNT11 WNT9B WNT9B FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
GREM1Gremlin. (184 aa)
GCNT3Glucosaminyl (N-acetyl) transferase 3, mucin type. (438 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
GCNT4Glucosaminyl (N-acetyl) transferase 4. (453 aa)
SOX4Transcription factor SOX. (475 aa)
COMMD5COMM domain containing 5. (224 aa)
GCNT1Glucosaminyl (N-acetyl) transferase 1. (428 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
TACSTD2Tumor associated calcium signal transducer 2. (339 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1. (298 aa)
WNK4Protein kinase domain-containing protein. (483 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1873 aa)
IRX2Iroquois homeobox 2. (378 aa)
IRX1Iroquois homeobox 1. (418 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (889 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
CTNNB1Catenin beta 1. (781 aa)
AHI1Abelson helper integration site 1. (1202 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TCF21Transcription factor 21. (179 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
ENSCSAP00000011565Uncharacterized protein. (57 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GLI3GLI family zinc finger 3. (1459 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HOXD11Homeobox D11. (338 aa)
HOXA11Homeobox A11. (310 aa)
SIX1SIX homeobox 1. (284 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (586 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
GATA3GATA binding protein 3. (443 aa)
SIX2SIX homeobox 2. (290 aa)
KLHL3Kelch like family member 3. (587 aa)
CALB1Calbindin 1. (261 aa)
ASXL1ASXL transcriptional regulator 1. (1541 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
SOX8SRY-box transcription factor 8. (446 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
GZF1GDNF inducible zinc finger protein 1. (712 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (3853 aa)
PBX1PBX homeobox 1. (301 aa)
ENSCSAP00000005731Protein kinase domain-containing protein. (479 aa)
ERBB4Protein kinase domain-containing protein. (622 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1660 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
DLG1Uncharacterized protein; Belongs to the MAGUK family. (800 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
GPC3Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (452 aa)
GREB1Uncharacterized protein. (1418 aa)
ENSCSAP00000003756Uncharacterized protein. (400 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
FMN1Formin 1. (1291 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PTCH1Patched 1. (1452 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
HNF1BHNF1 homeobox B. (557 aa)
PAX2Paired box 2. (261 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SALL1Spalt like transcription factor 1. (1321 aa)
TMEM59LTransmembrane protein 59 like. (343 aa)
IRX3Iroquois homeobox 3. (416 aa)
WT1WT1 transcription factor. (320 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
FOXJ1Forkhead box J1. (421 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (3233 aa)
SOX9SRY-box transcription factor 9. (509 aa)
DCHS1Dachsous cadherin-related 1. (3296 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (859 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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