STRINGSTRING
HGS HGS UVRAG UVRAG VPS4A VPS4A ENSCSAP00000001087 ENSCSAP00000001087 TSG101 TSG101 MVB12A MVB12A CHMP2B CHMP2B LAPTM4A LAPTM4A VPS28 VPS28 RUBCN RUBCN PDCD6IP PDCD6IP LYST LYST TMEM50B TMEM50B CHMP5 CHMP5 UBAP1 UBAP1 VCP VCP SYTL4 SYTL4 UBXN6 UBXN6 RAB27A RAB27A CHMP4B CHMP4B LAPTM4B LAPTM4B STAM STAM CHMP4C CHMP4C MVB12B MVB12B RILP RILP LEPROTL1 LEPROTL1 CHMP4A CHMP4A STAM2 STAM2 PTPN23 PTPN23 CHMP7 CHMP7 CHMP3 CHMP3 VPS37A VPS37A VTA1 VTA1 VPS36 VPS36 RAB27B RAB27B VPS25 VPS25 EXPH5 EXPH5 CHMP1A CHMP1A SNF8 SNF8 CHMP6 CHMP6 VPS37B VPS37B RILPL1 RILPL1 CHMP2A CHMP2A SORT1 SORT1 LEPROT LEPROT TMEM50A TMEM50A ENSCSAP00000018972 ENSCSAP00000018972
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
UVRAGUV radiation resistance associated. (699 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
ENSCSAP00000001087UDENN domain-containing protein. (357 aa)
TSG101Tumor susceptibility 101. (390 aa)
MVB12AMultivesicular body subunit 12A. (273 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
LAPTM4ALysosomal protein transmembrane 4 alpha. (233 aa)
VPS28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (231 aa)
RUBCNRubicon autophagy regulator. (1011 aa)
PDCD6IPBRO1 domain-containing protein. (868 aa)
LYSTLysosomal trafficking regulator. (3804 aa)
TMEM50BTransmembrane protein 50B. (158 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
UBAP1Ubiquitin associated protein 1. (502 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
SYTL4Synaptotagmin like 4. (672 aa)
UBXN6UBX domain protein 6. (441 aa)
RAB27ARAB27A, member RAS oncogene family. (221 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
LAPTM4BLysosomal protein transmembrane 4 beta. (226 aa)
STAMSignal transducing adaptor molecule. (540 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
MVB12BMultivesicular body subunit 12B. (321 aa)
RILPRab interacting lysosomal protein. (395 aa)
LEPROTL1Leptin receptor overlapping transcript like 1. (131 aa)
CHMP4ACharged multivesicular body protein 4A. (222 aa)
STAM2Signal transducing adaptor molecule 2. (525 aa)
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1632 aa)
CHMP7Charged multivesicular body protein 7. (453 aa)
CHMP3Charged multivesicular body protein 3. (292 aa)
VPS37AVPS37A subunit of ESCRT-I. (396 aa)
VTA1Vesicle trafficking 1. (307 aa)
VPS36Vacuolar protein sorting 36 homolog. (386 aa)
RAB27BRAB27B, member RAS oncogene family. (218 aa)
VPS25Vacuolar protein sorting 25 homolog. (176 aa)
EXPH5Exophilin 5. (1934 aa)
CHMP1ACharged multivesicular body protein 1A. (196 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
CHMP6Charged multivesicular body protein 6. (201 aa)
VPS37BVPS37B subunit of ESCRT-I. (285 aa)
RILPL1Rab interacting lysosomal protein like 1. (385 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
SORT1Sortilin. (831 aa)
LEPROTLeptin receptor overlapping transcript. (131 aa)
TMEM50ATransmembrane protein 50A. (157 aa)
ENSCSAP00000018972UDENN domain-containing protein. (357 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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