STRINGSTRING
NUP107 NUP107 GREM1 GREM1 GPR4 GPR4 POU3F3 POU3F3 FOXC1 FOXC1 BASP1 BASP1 COMMD5 COMMD5 FOXC2 FOXC2 ENSCSAP00000017880 ENSCSAP00000017880 NOG NOG HES5 HES5 CTNNBIP1 CTNNBIP1 WNT4 WNT4 HEYL HEYL TACSTD2 TACSTD2 HS2ST1 HS2ST1 NOTCH2 NOTCH2 KIRREL3 KIRREL3 ENSCSAP00000014771 ENSCSAP00000014771 WNK4 WNK4 EDNRA EDNRA BCL2 BCL2 SMAD4 SMAD4 GREB1L GREB1L EDNRB EDNRB IRX2 IRX2 IRX1 IRX1 ADAMTS16 ADAMTS16 IQGAP1 IQGAP1 ANGPT2 ANGPT2 GDNF GDNF CTNNB1 CTNNB1 AHI1 AHI1 TCF21 TCF21 PROM1 PROM1 NOTCH1 NOTCH1 LAMA5 LAMA5 BMP7 BMP7 GLI3 GLI3 CD34 CD34 LAMB2 LAMB2 SULF2 SULF2 BMP4 BMP4 AQP1 AQP1 MEF2C MEF2C HOXD11 HOXD11 HOXA11 HOXA11 SIX1 SIX1 SULF1 SULF1 EYA1 EYA1 JAG1 JAG1 BMP2 BMP2 GATA3 GATA3 SIX2 SIX2 KLHL3 KLHL3 EGR1 EGR1 TFAP2B TFAP2B CALB1 CALB1 ASXL1 ASXL1 FGF1 FGF1 PGF PGF NPHS2 NPHS2 MYO1E MYO1E SOX8 SOX8 ENSCSAP00000008056 ENSCSAP00000008056 DLL1 DLL1 ANGPT1 ANGPT1 PDGFRB PDGFRB WWTR1 WWTR1 CITED1 CITED1 GZF1 GZF1 PKD1 PKD1 EXT1 EXT1 PBX1 PBX1 MTSS1 MTSS1 SMO SMO TEK TEK NID1 NID1 MPV17 MPV17 PODXL PODXL ENSCSAP00000005731 ENSCSAP00000005731 ERBB4 ERBB4 KIF26B KIF26B HS3ST3A1 HS3ST3A1 HS3ST3B1 HS3ST3B1 DLG1 DLG1 WNT6 WNT6 PTPRO PTPRO KLF15 KLF15 OSR1 OSR1 GPC3 GPC3 GREB1 GREB1 ENSCSAP00000003756 ENSCSAP00000003756 COL4A4 COL4A4 COL4A3 COL4A3 FMN1 FMN1 SHH SHH PTCH1 PTCH1 PDGFB PDGFB WNT1 WNT1 PLCE1 PLCE1 NOTCH3 NOTCH3 HNF1B HNF1B NUP160 NUP160 PAX2 PAX2 LZTS2 LZTS2 FGF8 FGF8 WNT7B WNT7B SALL1 SALL1 TMEM59L TMEM59L IRX3 IRX3 WT1 WT1 LGR4 LGR4 ITGA3 ITGA3 FOXJ1 FOXJ1 NUP85 NUP85 SOX9 SOX9 DCHS1 DCHS1 NPHS1 NPHS1 PKD2 PKD2 PECAM1 PECAM1 WNT11 WNT11 ENPEP ENPEP AQP11 AQP11 WNT9B WNT9B FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
GREM1Gremlin. (184 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
POU3F3POU domain protein. (452 aa)
FOXC1Forkhead box C1. (552 aa)
BASP1Brain abundant membrane attached signal protein 1. (227 aa)
COMMD5COMM domain containing 5. (224 aa)
FOXC2Forkhead box C2. (501 aa)
ENSCSAP00000017880Uncharacterized protein. (78 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
TACSTD2Tumor associated calcium signal transducer 2. (339 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1. (298 aa)
NOTCH2Notch receptor 2. (2471 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (745 aa)
ENSCSAP00000014771Uncharacterized protein. (1348 aa)
WNK4Protein kinase domain-containing protein. (483 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1873 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (442 aa)
IRX2Iroquois homeobox 2. (378 aa)
IRX1Iroquois homeobox 1. (418 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (889 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
ANGPT2Angiopoietin 2. (495 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
CTNNB1Catenin beta 1. (781 aa)
AHI1Abelson helper integration site 1. (1202 aa)
TCF21Transcription factor 21. (179 aa)
PROM1Prominin 1. (855 aa)
NOTCH1Notch receptor 1. (2555 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GLI3GLI family zinc finger 3. (1459 aa)
CD34CD34 molecule. (385 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (950 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
MEF2CMyocyte enhancer factor 2C. (446 aa)
HOXD11Homeobox D11. (338 aa)
HOXA11Homeobox A11. (310 aa)
SIX1SIX homeobox 1. (284 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (586 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
GATA3GATA binding protein 3. (443 aa)
SIX2SIX homeobox 2. (290 aa)
KLHL3Kelch like family member 3. (587 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
TFAP2BTranscription factor AP-2 beta. (471 aa)
CALB1Calbindin 1. (261 aa)
ASXL1ASXL transcriptional regulator 1. (1541 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
NPHS2NPHS2 stomatin family member, podocin. (383 aa)
MYO1EMyosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa)
SOX8SRY-box transcription factor 8. (446 aa)
ENSCSAP00000008056Uncharacterized protein. (534 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
ANGPT1Angiopoietin 1. (407 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
GZF1GDNF inducible zinc finger protein 1. (712 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (3853 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (420 aa)
PBX1PBX homeobox 1. (301 aa)
MTSS1MTSS I-BAR domain containing 1. (690 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
TEKTEK receptor tyrosine kinase. (1123 aa)
NID1Nidogen 1. (1249 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (187 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (535 aa)
ENSCSAP00000005731Protein kinase domain-containing protein. (479 aa)
ERBB4Protein kinase domain-containing protein. (622 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1660 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
DLG1Uncharacterized protein; Belongs to the MAGUK family. (800 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1023 aa)
KLF15Kruppel like factor 15. (416 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
GPC3Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (452 aa)
GREB1Uncharacterized protein. (1418 aa)
ENSCSAP00000003756Uncharacterized protein. (400 aa)
COL4A4Collagen type IV alpha 4 chain. (1692 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
FMN1Formin 1. (1291 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PTCH1Patched 1. (1452 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PLCE1Phosphoinositide phospholipase C. (2317 aa)
NOTCH3Notch receptor 3. (1980 aa)
HNF1BHNF1 homeobox B. (557 aa)
NUP160Nucleoporin 160. (1429 aa)
PAX2Paired box 2. (261 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SALL1Spalt like transcription factor 1. (1321 aa)
TMEM59LTransmembrane protein 59 like. (343 aa)
IRX3Iroquois homeobox 3. (416 aa)
WT1WT1 transcription factor. (320 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1049 aa)
FOXJ1Forkhead box J1. (421 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa)
SOX9SRY-box transcription factor 9. (509 aa)
DCHS1Dachsous cadherin-related 1. (3296 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1242 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (859 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (738 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ENPEPAminopeptidase. (958 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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