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HCN4 HCN4 YWHAE YWHAE SCN5A SCN5A KCNJ3 KCNJ3 ISL1 ISL1 CAV1 CAV1 HCN1 HCN1 BIN1 BIN1 DSG2 DSG2 DSC2 DSC2 JUP JUP KCNA5 KCNA5 KCNE4 KCNE4 KCNE1 KCNE1 CACNA1C CACNA1C KCNE2 KCNE2 KCNE5 KCNE5 KCNJ2 KCNJ2 KCNE3 KCNE3 HCN3 HCN3 KCNJ5 KCNJ5 SCN2B SCN2B SCN4B SCN4B TRPM4 TRPM4 CACNA2D1 CACNA2D1 ENSCSAP00000000163 ENSCSAP00000000163 ANK2 ANK2 KCNH6 KCNH6 SCN1B SCN1B CACNA1G CACNA1G KCNH2 KCNH2 PKP2 PKP2 DSP DSP CTNNA3 CTNNA3 KCNQ1 KCNQ1 AKAP9 AKAP9 CACNB2 CACNB2 HCN2 HCN2 CACNA1D CACNA1D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (240 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1881 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
ISL1ISL LIM homeobox 1. (349 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
HCN1Cyclic nucleotide-binding domain-containing protein. (604 aa)
BIN1Bridging integrator 1. (608 aa)
DSG2Desmoglein 2. (1118 aa)
DSC2Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (901 aa)
JUPJunction plakoglobin. (745 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (170 aa)
KCNE1Uncharacterized protein. (146 aa)
CACNA1CCalcium voltage-gated channel subunit alpha1 C. (1898 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (777 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (432 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1214 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (962 aa)
ENSCSAP00000000163Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (489 aa)
ANK2Ankyrin 2. (4035 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (994 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (218 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2186 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1160 aa)
PKP2Plakophilin 2. (837 aa)
DSPDesmoplakin. (2871 aa)
CTNNA3Uncharacterized protein. (305 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (518 aa)
AKAP9A-kinase anchoring protein 9. (3922 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (612 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (806 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2036 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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