STRINGSTRING
SMURF2 SMURF2 CXCL13 CXCL13 HTRA1 HTRA1 CREB3L1 CREB3L1 GPC1 GPC1 WNT1 WNT1 DAND5 DAND5 HHEX HHEX NF1 NF1 DKK1 DKK1 THBS1 THBS1 UBE2D1 UBE2D1 TMPRSS6 TMPRSS6 EPN2 EPN2 HIPK2 HIPK2 APLN APLN CHRDL1 CHRDL1 CER1 CER1 VWC2L VWC2L EMILIN1 EMILIN1 CTDSPL2 CTDSPL2 LEMD2 LEMD2 MMRN2 MMRN2 GDF3 GDF3 FBN1 FBN1 AGT AGT PIK3CB PIK3CB XDH XDH BAMBI BAMBI NEDD4 NEDD4 CRIM1 CRIM1 IL12A IL12A SPRY4 SPRY4 RBPMS2 RBPMS2 FSTL3 FSTL3 WNT5A WNT5A SMAD6 SMAD6 DAB2IP DAB2IP SKOR1 SKOR1 GATA3 GATA3 SOSTDC1 SOSTDC1 CHRD CHRD NIBAN2 NIBAN2 IL4 IL4 PRDM14 PRDM14 SULF1 SULF1 HRG HRG PPM1A PPM1A ATP2B4 ATP2B4 SEMA6A SEMA6A ABL1 ABL1 DLX1 DLX1 BMPER BMPER SULF2 SULF2 SFRP1 SFRP1 PTPN1 PTPN1 LRP2 LRP2 ADGRA2 ADGRA2 NOTCH1 NOTCH1 HTRA3 HTRA3 VWC2 VWC2 TNFAIP6 TNFAIP6 ENSCSAP00000012589 ENSCSAP00000012589 SLIT2 SLIT2 ADAMTS12 ADAMTS12 TWSG1 TWSG1 SMURF1 SMURF1 SPART SPART SHISA2 SHISA2 SKOR2 SKOR2 SMAD7 SMAD7 SOST SOST SFRP2 SFRP2 NGFR NGFR SORL1 SORL1 FUZ FUZ HGS HGS HJV HJV TRIM33 TRIM33 WNT4 WNT4 NBL1 NBL1 SKI SKI NOG NOG SPRY3 SPRY3 SPRY1 SPRY1 SPRY2 SPRY2 FZD1 FZD1 GREM2 GREM2 AGTR2 AGTR2 GREM1 GREM1 DCN DCN CHRDL2 CHRDL2 LEMD3 LEMD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (474 aa)
CXCL13C-X-C motif chemokine. (109 aa)
HTRA1HtrA serine peptidase 1. (524 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
HHEXHematopoietically expressed homeobox. (268 aa)
NF1Neurofibromin 1. (2849 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
THBS1Thrombospondin 1. (1170 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (800 aa)
EPN2Epsin 2. (584 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
APLNApelin. (77 aa)
CHRDL1Chordin like 1. (458 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (174 aa)
EMILIN1Elastin microfibril interfacer 1. (860 aa)
CTDSPL2CTD small phosphatase like 2. (466 aa)
LEMD2LEM domain containing 2. (509 aa)
MMRN2Multimerin 2. (951 aa)
GDF3Growth differentiation factor 3. (364 aa)
FBN1Fibrillin 1. (2666 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
XDHXanthine dehydrogenase. (1339 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
NEDD4E3 ubiquitin-protein ligase. (900 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1036 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
SPRY4Sprouty RTK signaling antagonist 4. (322 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (217 aa)
FSTL3Follistatin like 3. (263 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
DAB2IPDAB2 interacting protein. (1036 aa)
SKOR1SKI family transcriptional corepressor 1. (964 aa)
GATA3GATA binding protein 3. (443 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (956 aa)
NIBAN2Niban apoptosis regulator 2. (746 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
PRDM14PR/SET domain 14. (571 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
HRGHistidine rich glycoprotein. (521 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1170 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1043 aa)
ABL1Tyrosine-protein kinase. (1130 aa)
DLX1Distal-less homeobox 1. (255 aa)
BMPERBMP binding endothelial regulator. (685 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (950 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
LRP2LDL receptor related protein 2. (3861 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1338 aa)
NOTCH1Notch receptor 1. (2555 aa)
HTRA3HtrA serine peptidase 3. (470 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
ENSCSAP00000012589LRRNT domain-containing protein. (132 aa)
SLIT2Slit guidance ligand 2. (1332 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
SMURF1E3 ubiquitin-protein ligase. (728 aa)
SPARTSpartin. (666 aa)
SHISA2Shisa family member 2. (295 aa)
SKOR2SKI family transcriptional corepressor 2. (1001 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SOSTSclerostin. (213 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
NGFRNerve growth factor receptor. (427 aa)
SORL1Sortilin related receptor 1. (2214 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
TRIM33Tripartite motif containing 33. (1127 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (181 aa)
SKISKI proto-oncogene. (728 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SPRY3Sprouty RTK signaling antagonist 3. (288 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa)
GREM2Gremlin. (168 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
GREM1Gremlin. (184 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
CHRDL2Chordin like 2. (429 aa)
LEMD3LEM domain containing 3. (911 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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