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| | NOP14 | NOP14 nucleolar protein. (857 aa) |
| | ANGEL2 | Angel homolog 2. (544 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (397 aa) |
| | ANKRD31 | RAMA domain-containing protein. (512 aa) |
| | TATDN3 | TatD DNase domain containing 3. (273 aa) |
| | FANCM | FA complementation group M. (2050 aa) |
| | REXO4 | REX4 homolog, 3'-5' exonuclease. (422 aa) |
| | NUDT12 | Nudix hydrolase 12. (462 aa) |
| | CCDC36 | Coiled-coil domain containing 36. (580 aa) |
| | DCP2 | Decapping mRNA 2. (420 aa) |
| | APLF | Aprataxin and PNKP like factor. (511 aa) |
| | EXOSC2 | Exosome component 2. (293 aa) |
| | ENDOV | Endonuclease V. (308 aa) |
| | DCPS | Decapping enzyme, scavenger. (339 aa) |
| | POP5 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (163 aa) |
| | POLD1 | DNA polymerase. (1086 aa) |
| | ISG20L2 | Interferon stimulated exonuclease gene 20 like 2. (353 aa) |
| | PIWIL1 | Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (861 aa) |
| | TSEN34 | tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (310 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (532 aa) |
| | ENSCSAP00000016536 | Uncharacterized protein. (286 aa) |
| | DNASE2B | Deoxyribonuclease 2 beta. (361 aa) |
| | TOE1 | Target of EGR1, exonuclease. (509 aa) |
| | ERI3 | ERI1 exoribonuclease family member 3. (337 aa) |
| | SLFNL1 | Schlafen like 1. (407 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (601 aa) |
| | AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa) |
| | LOC103231340 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (685 aa) |
| | EXOSC7 | Exosome component 7. (291 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | ZC3H12C | Zinc finger CCCH-type containing 12C. (884 aa) |
| | ENSCSAP00000015264 | Exonuclease domain-containing protein. (330 aa) |
| | REXO2 | RNA exonuclease 2. (237 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) |
| | ERCC2 | ERCC excision repair 2, TFIIH core complex helicase subunit. (736 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase 3. (941 aa) |
| | RNASE4 | Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (147 aa) |
| | EXD3 | Exonuclease 3'-5' domain containing 3. (875 aa) |
| | PIWIL2 | Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (973 aa) |
| | HELZ2 | Helicase with zinc finger 2. (2822 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1016 aa) |
| | ENDOD1 | Endonuclease domain containing 1. (500 aa) |
| | UTP20 | UTP20 small subunit processome component. (2785 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | EXOSC5 | Exosome component 5. (260 aa) |
| | NOCT | Nocturnin. (365 aa) |
| | ENSCSAP00000014110 | Uncharacterized protein. (86 aa) |
| | ELAC1 | ElaC ribonuclease Z 1. (279 aa) |
| | HORMAD1 | HORMA domain containing 1. (394 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (887 aa) |
| | POP7 | Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa) |
| | N4BP2L1 | NEDD4 binding protein 2 like 1. (229 aa) |
| | EXOSC8 | Exosome component 8. (276 aa) |
| | AZGP1 | Alpha-2-glycoprotein 1, zinc-binding; Belongs to the MHC class I family. (298 aa) |
| | CPSF4 | Cleavage and polyadenylation specific factor 4. (269 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (862 aa) |
| | DNASE1L1 | Deoxyribonuclease; Belongs to the DNase I family. (302 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | DIS3 | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa) |
| | BIVM | Basic, immunoglobulin-like variable motif containing. (503 aa) |
| | ERCC5 | ERCC excision repair 5, endonuclease. (1182 aa) |
| | MEI4 | Meiotic double-stranded break formation protein 4. (389 aa) |
| | ZC3H12D | Zinc finger CCCH-type containing 12D. (530 aa) |
| | DROSHA | Drosha ribonuclease III. (1379 aa) |
| | AEN | Apoptosis enhancing nuclease. (325 aa) |
| | ISG20 | Interferon stimulated exonuclease gene 20. (181 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1228 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (280 aa) |
| | N4BP2 | NEDD4 binding protein 2. (1770 aa) |
| | ERI1 | Exoribonuclease 1. (349 aa) |
| | CNOT7 | CCR4-NOT transcription complex subunit 7. (285 aa) |
| | TSN | Translin. (228 aa) |
| | PELO | Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa) |
| | LOC103231340-2 | DNA-(apurinic or apyrimidinic site) lyase. (318 aa) |
| | ENSCSAP00000012217 | Uncharacterized protein. (293 aa) |
| | RPS21 | 40S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa) |
| | NOP9 | NOP9 nucleolar protein. (639 aa) |
| | NYNRIN | NYN domain and retroviral integrase containing. (1898 aa) |
| | KHNYN | KH and NYN domain containing. (678 aa) |
| | UBXN8 | UBX domain protein 8. (269 aa) |
| | WRN | WRN RecQ like helicase. (1399 aa) |
| | PRORP | Uncharacterized protein. (581 aa) |
| | RPP25 | Ribonuclease P and MRP subunit p25. (199 aa) |
| | RIDA | Uncharacterized protein. (137 aa) |
| | MBLAC1 | Metallo-beta-lactamase domain containing 1. (266 aa) |
| | RPP38 | Ribonuclease P/MRP subunit p38. (282 aa) |
| | ENSCSAP00000018240 | Uncharacterized protein. (294 aa) |
| | ENSCSAP00000018116 | Exonuclease domain-containing protein. (599 aa) |
| | ENSCSAP00000018107 | Uncharacterized protein. (295 aa) |
| | RRS1 | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa) |
| | EXO5 | Exonuclease 5. (373 aa) |
| | RNASE8 | Ribonuclease A family member 8; Belongs to the pancreatic ribonuclease family. (154 aa) |
| | RNASE7 | RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (156 aa) |
| | RNASE2 | Ribonuclease A family member 2; Belongs to the pancreatic ribonuclease family. (160 aa) |
| | RNASE1 | Ribonuclease A family member 1, pancreatic; Belongs to the pancreatic ribonuclease family. (152 aa) |
| | RNASE6 | Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. (150 aa) |
| | RNASE12 | Ribonuclease A family member 12 (inactive); Belongs to the pancreatic ribonuclease family. (147 aa) |
| | RNASE11 | Ribonuclease A family member 11 (inactive); Belongs to the pancreatic ribonuclease family. (199 aa) |
| | ENSCSAP00000017611 | Uncharacterized protein. (295 aa) |
| | ENSCSAP00000017561 | Uncharacterized protein. (294 aa) |
| | ENSCSAP00000017472 | ERCC4 domain-containing protein. (551 aa) |
| | FCF1 | PINc domain-containing protein. (198 aa) |
| | PNRC2 | Proline rich nuclear receptor coactivator 2. (139 aa) |
| | INTS11 | Integrator complex subunit 11. (600 aa) |
| | NOL9 | Nucleolar protein 9. (700 aa) |
| | EXOSC10 | Exosome component 10. (884 aa) |
| | PPP1R8 | Protein phosphatase 1 regulatory subunit 8. (351 aa) |
| | AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa) |
| | PXDNL | Peroxidasin like. (1336 aa) |
| | EXOG | Exo/endonuclease G. (344 aa) |
| | ENDOG | Endonuclease. (299 aa) |
| | EDC3 | Enhancer of mRNA decapping 3. (508 aa) |
| | PNPT1 | Polyribonucleotide nucleotidyltransferase 1. (784 aa) |
| | ENSCSAP00000010000 | Uncharacterized protein. (254 aa) |
| | LACTB2 | Lactamase beta 2. (288 aa) |
| | SMG6 | SMG6 nonsense mediated mRNA decay factor. (1419 aa) |
| | POLR3K | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa) |
| | DIS3L | DIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (971 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (636 aa) |
| | DCP1A | Decapping mRNA 1A. (582 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (639 aa) |
| | ENSCSAP00000009094 | Uncharacterized protein. (717 aa) |
| | SWT1 | SWT1 RNA endoribonuclease homolog. (903 aa) |
| | TSEN15 | tRNA splicing endonuclease subunit 15. (183 aa) |
| | ARID3A | AT-rich interaction domain 3A. (498 aa) |
| | RNASEL | Ribonuclease L. (741 aa) |
| | PNLDC1 | PARN like, ribonuclease domain containing 1. (522 aa) |
| | POP1 | POP1 homolog, ribonuclease P/MRP subunit. (929 aa) |
| | PDE12 | Phosphodiesterase 12. (608 aa) |
| | RNASEK | Ribonuclease K. (137 aa) |
| | DNASE1L3 | Deoxyribonuclease 1 like 3. (165 aa) |
| | RPP14 | Ribonuclease P/MRP subunit p14. (71 aa) |
| | RNASET2 | Uncharacterized protein; Belongs to the RNase T2 family. (218 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa) |
| | ZC3H12B | Uncharacterized protein. (333 aa) |
| | LAS1L | LAS1 like, ribosome biogenesis factor. (722 aa) |
| | ANGEL1 | Angel homolog 1. (680 aa) |
| | REXO1 | RNA exonuclease 1 homolog. (1218 aa) |
| | RRP36 | Ribosomal RNA processing 36. (257 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (342 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (463 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (383 aa) |
| | PLSCR1 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (313 aa) |
| | CPSF2 | Cleavage and polyadenylation specificity factor subunit 2. (782 aa) |
| | XRN1 | 5'-3' exoribonuclease 1. (1707 aa) |
| | MEIOB | Meiosis specific with OB-fold. (472 aa) |
| | TBL3 | Transducin beta like 3. (808 aa) |
| | BMS1 | BMS1 ribosome biogenesis factor. (1283 aa) |
| | XRN2 | 5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa) |
| | B4GALNT4 | Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1039 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa) |
| | SETMAR | SET domain and mariner transposase fusion gene. (684 aa) |
| | DBR1 | Debranching RNA lariats 1. (544 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (226 aa) |
| | UTP23 | UTP23 small subunit processome component. (249 aa) |
| | NCBP1 | Nuclear cap binding protein subunit 1. (790 aa) |
| | G3BP1 | G3BP stress granule assembly factor 1. (466 aa) |
| | ENSCSAP00000007055 | Uncharacterized protein. (251 aa) |
| | ENPP2 | Ectonucleotide pyrophosphatase/phosphodiesterase 2. (940 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | DNASE1L2 | Deoxyribonuclease; Belongs to the DNase I family. (279 aa) |
| | CNOT8 | CCR4-NOT transcription complex subunit 8. (292 aa) |
| | DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1920 aa) |
| | OGG1 | 8-oxoguanine DNA glycosylase. (405 aa) |
| | PGBD5 | PiggyBac transposable element derived 5. (524 aa) |
| | NUDT16 | Nudix hydrolase 16. (195 aa) |
| | ASTE1 | Asteroid homolog 1. (679 aa) |
| | PIWIL3 | Piwi like RNA-mediated gene silencing 3; Belongs to the argonaute family. (870 aa) |
| | TATDN1 | TatD DNase domain containing 1. (281 aa) |
| | SND1 | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa) |
| | TATDN2 | Uncharacterized protein. (761 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa) |
| | DNASE1 | Deoxyribonuclease; Belongs to the DNase I family. (288 aa) |
| | APTX | Aprataxin. (356 aa) |
| | TSEN2 | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (466 aa) |
| | PLD4 | Phospholipase D family member 4. (515 aa) |
| | AGO2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (904 aa) |
| | EXO1 | Exonuclease 1. (845 aa) |
| | ELAC2 | ElaC ribonuclease Z 2. (826 aa) |
| | MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (572 aa) |
| | DXO | Decapping exoribonuclease. (396 aa) |
| | RCL1 | RNA terminal phosphate cyclase like 1. (373 aa) |
| | EXOSC4 | Exosome component 4. (245 aa) |
| | BOP1 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (745 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | CPSF1 | Cleavage and polyadenylation specific factor 1. (1442 aa) |
| | PLD6 | Phospholipase D family member 6. (249 aa) |
| | C11orf80 | Chromosome 11 open reading frame 80. (524 aa) |
| | CNOT6 | CCR4-NOT transcription complex subunit 6. (557 aa) |
| | RPP21 | Ribonuclease P/MRP subunit p21. (154 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (735 aa) |
| | PARN | Poly(A)-specific ribonuclease. (639 aa) |
| | ZNRD1 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa) |
| | MARF1 | Meiosis regulator and mRNA stability factor 1. (1742 aa) |
| | ABT1 | Activator of basal transcription 1. (276 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (907 aa) |
| | DDX1 | DEAD-box helicase 1. (740 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (358 aa) |
| | MRPL44 | Mitochondrial ribosomal protein L44. (280 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | ERI2 | ERI1 exoribonuclease family member 2. (691 aa) |
| | REXO5 | RNA exonuclease 5. (772 aa) |
| | RPP40 | Ribonuclease P/MRP subunit p40. (363 aa) |
| | YBEY | YbeY metalloendoribonuclease. (147 aa) |
| | CPSF3 | Cleavage and polyadenylation specific factor 3. (631 aa) |
| | KRI1 | KRI1 homolog. (590 aa) |
| | HAUS7 | HAUS augmin like complex subunit 7. (387 aa) |
| | RNASEH1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa) |
| | ENDOU | Endonuclease, poly(U) specific. (391 aa) |
| | RPP30 | Ribonuclease P/MRP subunit p30. (268 aa) |
| | ERN2 | Endoplasmic reticulum to nucleus signaling 2. (929 aa) |
| | DIS3L2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (918 aa) |
| | TRIR | Telomerase RNA component interacting RNase. (176 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa) |
| | TUT1 | PAP-associated domain-containing protein. (784 aa) |
| | DNASE2 | Deoxyribonuclease 2, lysosomal. (251 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1838 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (346 aa) |
| | CPSF7 | Cleavage and polyadenylation specific factor 7. (462 aa) |
| | SLFN12 | Schlafen family member 12. (580 aa) |
| | SLFN12L | Schlafen family member 12 like. (616 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | RAD51C | RAD51 paralog C. (367 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (615 aa) |
| | NME1 | Nucleoside diphosphate kinase. (152 aa) |
| | C12orf10 | Chromosome 12 open reading frame 10. (380 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (953 aa) |
| | N4BP1 | NEDD4 binding protein 1. (810 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) |
| | TTC38 | Tetratricopeptide repeat domain 38. (475 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1202 aa) |
| | NUDT21 | Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (1040 aa) |
| | POP4 | Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (218 aa) |
| | USB1 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family. (265 aa) |
| | CNOT1 | CCR4-NOT transcription complex subunit 1. (2376 aa) |
| | CNOT6L | CCR4-NOT transcription complex subunit 6 like. (555 aa) |
| | CPSF4L | Cleavage and polyadenylation specific factor 4 like. (180 aa) |
| | LRRC27 | Leucine rich repeat containing 27. (529 aa) |
| | POLR2I | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa) |
| | CPSF6 | Cleavage and polyadenylation specific factor 6. (588 aa) |
| | CNOT2 | CCR4-NOT transcription complex subunit 2. (540 aa) |
| | NOB1 | RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (412 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (977 aa) |
| | EDC4 | Enhancer of mRNA decapping 4. (1401 aa) |
| | RPS3 | Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | ZGRF1 | Zinc finger GRF-type containing 1. (2109 aa) |
| | PLD3 | Phospholipase D family member 3. (490 aa) |
| | EXOSC9 | Exosome component 9. (439 aa) |
| | PCF11 | PCF11 cleavage and polyadenylation factor subunit. (1555 aa) |
