STRINGSTRING
NOP14 NOP14 ANGEL2 ANGEL2 SPO11 SPO11 ANKRD31 ANKRD31 TATDN3 TATDN3 FANCM FANCM REXO4 REXO4 NUDT12 NUDT12 CCDC36 CCDC36 DCP2 DCP2 APLF APLF EXOSC2 EXOSC2 ENDOV ENDOV DCPS DCPS POP5 POP5 POLD1 POLD1 ISG20L2 ISG20L2 PIWIL1 PIWIL1 TSEN34 TSEN34 POLE POLE DCLRE1B DCLRE1B ENSCSAP00000016536 ENSCSAP00000016536 DNASE2B DNASE2B TOE1 TOE1 ERI3 ERI3 SLFNL1 SLFNL1 ZC3H12A ZC3H12A AGO3 AGO3 LOC103231340 LOC103231340 ENPP1 ENPP1 EXOSC7 EXOSC7 ERCC1 ERCC1 ZC3H12C ZC3H12C ENSCSAP00000015264 ENSCSAP00000015264 REXO2 REXO2 PNKP PNKP ERCC2 ERCC2 ENPP3 ENPP3 RNASE4 RNASE4 EXD3 EXD3 PIWIL2 PIWIL2 HELZ2 HELZ2 ZRANB3 ZRANB3 ENDOD1 ENDOD1 UTP20 UTP20 MRE11 MRE11 EXOSC5 EXOSC5 NOCT NOCT ENSCSAP00000014110 ENSCSAP00000014110 ELAC1 ELAC1 HORMAD1 HORMAD1 PAN3 PAN3 POP7 POP7 N4BP2L1 N4BP2L1 EXOSC8 EXOSC8 AZGP1 AZGP1 CPSF4 CPSF4 PMS2 PMS2 DNASE1L1 DNASE1L1 RBBP8 RBBP8 DIS3 DIS3 BIVM BIVM ERCC5 ERCC5 MEI4 MEI4 ZC3H12D ZC3H12D DROSHA DROSHA AEN AEN ISG20 ISG20 POLG POLG RAD1 RAD1 N4BP2 N4BP2 ERI1 ERI1 CNOT7 CNOT7 TSN TSN PELO PELO LOC103231340-2 LOC103231340-2 ENSCSAP00000012217 ENSCSAP00000012217 RPS21 RPS21 NOP9 NOP9 NYNRIN NYNRIN KHNYN KHNYN UBXN8 UBXN8 WRN WRN PRORP PRORP RPP25 RPP25 RIDA RIDA MBLAC1 MBLAC1 RPP38 RPP38 ENSCSAP00000018240 ENSCSAP00000018240 ENSCSAP00000018116 ENSCSAP00000018116 ENSCSAP00000018107 ENSCSAP00000018107 RRS1 RRS1 EXO5 EXO5 RNASE8 RNASE8 RNASE7 RNASE7 RNASE2 RNASE2 RNASE1 RNASE1 RNASE6 RNASE6 RNASE12 RNASE12 RNASE11 RNASE11 ENSCSAP00000017611 ENSCSAP00000017611 ENSCSAP00000017561 ENSCSAP00000017561 ENSCSAP00000017472 ENSCSAP00000017472 FCF1 FCF1 PNRC2 PNRC2 INTS11 INTS11 NOL9 NOL9 EXOSC10 EXOSC10 PPP1R8 PPP1R8 AGO4 AGO4 PXDNL PXDNL EXOG EXOG ENDOG ENDOG EDC3 EDC3 PNPT1 PNPT1 ENSCSAP00000010000 ENSCSAP00000010000 LACTB2 LACTB2 SMG6 SMG6 POLR3K POLR3K DIS3L DIS3L EXD2 EXD2 DCP1A DCP1A DCLRE1C DCLRE1C ENSCSAP00000009094 ENSCSAP00000009094 SWT1 SWT1 TSEN15 TSEN15 ARID3A ARID3A RNASEL RNASEL PNLDC1 PNLDC1 POP1 POP1 PDE12 PDE12 RNASEK RNASEK DNASE1L3 DNASE1L3 RPP14 RPP14 RNASET2 RNASET2 APEX2 APEX2 ZC3H12B ZC3H12B LAS1L LAS1L ANGEL1 ANGEL1 REXO1 REXO1 RRP36 RRP36 MGME1 MGME1 TDP1 TDP1 EME2 EME2 PLSCR1 PLSCR1 CPSF2 CPSF2 XRN1 XRN1 MEIOB MEIOB TBL3 TBL3 BMS1 BMS1 XRN2 XRN2 B4GALNT4 B4GALNT4 NTHL1 NTHL1 SETMAR SETMAR DBR1 DBR1 XPA XPA UTP23 UTP23 NCBP1 NCBP1 G3BP1 G3BP1 ENSCSAP00000007055 ENSCSAP00000007055 ENPP2 ENPP2 EXOSC3 EXOSC3 DNASE1L2 DNASE1L2 CNOT8 CNOT8 DICER1 DICER1 OGG1 OGG1 PGBD5 PGBD5 NUDT16 NUDT16 ASTE1 ASTE1 PIWIL3 PIWIL3 TATDN1 TATDN1 SND1 SND1 TATDN2 TATDN2 SAMHD1 SAMHD1 DNASE1 DNASE1 APTX APTX TSEN2 TSEN2 PLD4 PLD4 AGO2 AGO2 EXO1 EXO1 ELAC2 ELAC2 MBD4 MBD4 DXO DXO RCL1 RCL1 EXOSC4 EXOSC4 BOP1 BOP1 RAD9A RAD9A CPSF1 CPSF1 PLD6 PLD6 C11orf80 C11orf80 CNOT6 CNOT6 RPP21 RPP21 ERCC4 ERCC4 PARN PARN ZNRD1 ZNRD1 MARF1 MARF1 ABT1 ABT1 GEN1 GEN1 DDX1 DDX1 TDP2 TDP2 MRPL44 MRPL44 DNA2 DNA2 ERI2 ERI2 REXO5 REXO5 RPP40 RPP40 YBEY YBEY CPSF3 CPSF3 KRI1 KRI1 HAUS7 HAUS7 RNASEH1 RNASEH1 FAN1 FAN1 ENDOU ENDOU RPP30 RPP30 ERN2 ERN2 DIS3L2 DIS3L2 TRIR TRIR RNASEH2A RNASEH2A TUT1 TUT1 DNASE2 DNASE2 ATAD5 ATAD5 FEN1 FEN1 CPSF7 CPSF7 SLFN12 SLFN12 SLFN12L SLFN12L SLX1 SLX1 RAD51C RAD51C ANKLE1 ANKLE1 NME1 NME1 C12orf10 C12orf10 RAG1 RAG1 N4BP1 N4BP1 EME1 EME1 TTC38 TTC38 PAN2 PAN2 NUDT21 NUDT21 DCLRE1A DCLRE1A POP4 POP4 USB1 USB1 CNOT1 CNOT1 CNOT6L CNOT6L CPSF4L CPSF4L LRRC27 LRRC27 POLR2I POLR2I CPSF6 CPSF6 CNOT2 CNOT2 NOB1 NOB1 ERN1 ERN1 EDC4 EDC4 RPS3 RPS3 ZGRF1 ZGRF1 PLD3 PLD3 EXOSC9 EXOSC9 PCF11 PCF11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOP14NOP14 nucleolar protein. (857 aa)
ANGEL2Angel homolog 2. (544 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (397 aa)
ANKRD31RAMA domain-containing protein. (512 aa)
TATDN3TatD DNase domain containing 3. (273 aa)
FANCMFA complementation group M. (2050 aa)
REXO4REX4 homolog, 3'-5' exonuclease. (422 aa)
NUDT12Nudix hydrolase 12. (462 aa)
CCDC36Coiled-coil domain containing 36. (580 aa)
DCP2Decapping mRNA 2. (420 aa)
APLFAprataxin and PNKP like factor. (511 aa)
EXOSC2Exosome component 2. (293 aa)
ENDOVEndonuclease V. (308 aa)
DCPSDecapping enzyme, scavenger. (339 aa)
POP5Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (163 aa)
POLD1DNA polymerase. (1086 aa)
ISG20L2Interferon stimulated exonuclease gene 20 like 2. (353 aa)
PIWIL1Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (861 aa)
TSEN34tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (310 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
ENSCSAP00000016536Uncharacterized protein. (286 aa)
DNASE2BDeoxyribonuclease 2 beta. (361 aa)
TOE1Target of EGR1, exonuclease. (509 aa)
ERI3ERI1 exoribonuclease family member 3. (337 aa)
SLFNL1Schlafen like 1. (407 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
LOC103231340DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (685 aa)
EXOSC7Exosome component 7. (291 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
ZC3H12CZinc finger CCCH-type containing 12C. (884 aa)
ENSCSAP00000015264Exonuclease domain-containing protein. (330 aa)
REXO2RNA exonuclease 2. (237 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (736 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (941 aa)
RNASE4Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (147 aa)
EXD3Exonuclease 3'-5' domain containing 3. (875 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (973 aa)
HELZ2Helicase with zinc finger 2. (2822 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1016 aa)
ENDOD1Endonuclease domain containing 1. (500 aa)
UTP20UTP20 small subunit processome component. (2785 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
EXOSC5Exosome component 5. (260 aa)
NOCTNocturnin. (365 aa)
ENSCSAP00000014110Uncharacterized protein. (86 aa)
ELAC1ElaC ribonuclease Z 1. (279 aa)
HORMAD1HORMA domain containing 1. (394 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (887 aa)
POP7Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (229 aa)
EXOSC8Exosome component 8. (276 aa)
AZGP1Alpha-2-glycoprotein 1, zinc-binding; Belongs to the MHC class I family. (298 aa)
CPSF4Cleavage and polyadenylation specific factor 4. (269 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (862 aa)
DNASE1L1Deoxyribonuclease; Belongs to the DNase I family. (302 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
BIVMBasic, immunoglobulin-like variable motif containing. (503 aa)
ERCC5ERCC excision repair 5, endonuclease. (1182 aa)
MEI4Meiotic double-stranded break formation protein 4. (389 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (530 aa)
DROSHADrosha ribonuclease III. (1379 aa)
AENApoptosis enhancing nuclease. (325 aa)
ISG20Interferon stimulated exonuclease gene 20. (181 aa)
POLGDNA polymerase gamma, catalytic subunit. (1228 aa)
RAD1RAD1 checkpoint DNA exonuclease. (280 aa)
N4BP2NEDD4 binding protein 2. (1770 aa)
ERI1Exoribonuclease 1. (349 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
TSNTranslin. (228 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
LOC103231340-2DNA-(apurinic or apyrimidinic site) lyase. (318 aa)
ENSCSAP00000012217Uncharacterized protein. (293 aa)
RPS2140S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
NOP9NOP9 nucleolar protein. (639 aa)
NYNRINNYN domain and retroviral integrase containing. (1898 aa)
KHNYNKH and NYN domain containing. (678 aa)
UBXN8UBX domain protein 8. (269 aa)
WRNWRN RecQ like helicase. (1399 aa)
PRORPUncharacterized protein. (581 aa)
RPP25Ribonuclease P and MRP subunit p25. (199 aa)
RIDAUncharacterized protein. (137 aa)
MBLAC1Metallo-beta-lactamase domain containing 1. (266 aa)
RPP38Ribonuclease P/MRP subunit p38. (282 aa)
ENSCSAP00000018240Uncharacterized protein. (294 aa)
ENSCSAP00000018116Exonuclease domain-containing protein. (599 aa)
ENSCSAP00000018107Uncharacterized protein. (295 aa)
RRS1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
EXO5Exonuclease 5. (373 aa)
RNASE8Ribonuclease A family member 8; Belongs to the pancreatic ribonuclease family. (154 aa)
RNASE7RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (156 aa)
RNASE2Ribonuclease A family member 2; Belongs to the pancreatic ribonuclease family. (160 aa)
RNASE1Ribonuclease A family member 1, pancreatic; Belongs to the pancreatic ribonuclease family. (152 aa)
RNASE6Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. (150 aa)
RNASE12Ribonuclease A family member 12 (inactive); Belongs to the pancreatic ribonuclease family. (147 aa)
RNASE11Ribonuclease A family member 11 (inactive); Belongs to the pancreatic ribonuclease family. (199 aa)
ENSCSAP00000017611Uncharacterized protein. (295 aa)
ENSCSAP00000017561Uncharacterized protein. (294 aa)
ENSCSAP00000017472ERCC4 domain-containing protein. (551 aa)
FCF1PINc domain-containing protein. (198 aa)
PNRC2Proline rich nuclear receptor coactivator 2. (139 aa)
INTS11Integrator complex subunit 11. (600 aa)
NOL9Nucleolar protein 9. (700 aa)
EXOSC10Exosome component 10. (884 aa)
PPP1R8Protein phosphatase 1 regulatory subunit 8. (351 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
PXDNLPeroxidasin like. (1336 aa)
EXOGExo/endonuclease G. (344 aa)
ENDOGEndonuclease. (299 aa)
EDC3Enhancer of mRNA decapping 3. (508 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (784 aa)
ENSCSAP00000010000Uncharacterized protein. (254 aa)
LACTB2Lactamase beta 2. (288 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1419 aa)
POLR3KDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
DIS3LDIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (971 aa)
EXD2Exonuclease 3'-5' domain containing 2. (636 aa)
DCP1ADecapping mRNA 1A. (582 aa)
DCLRE1CDNA cross-link repair 1C. (639 aa)
ENSCSAP00000009094Uncharacterized protein. (717 aa)
SWT1SWT1 RNA endoribonuclease homolog. (903 aa)
TSEN15tRNA splicing endonuclease subunit 15. (183 aa)
ARID3AAT-rich interaction domain 3A. (498 aa)
RNASELRibonuclease L. (741 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (522 aa)
POP1POP1 homolog, ribonuclease P/MRP subunit. (929 aa)
PDE12Phosphodiesterase 12. (608 aa)
RNASEKRibonuclease K. (137 aa)
DNASE1L3Deoxyribonuclease 1 like 3. (165 aa)
RPP14Ribonuclease P/MRP subunit p14. (71 aa)
RNASET2Uncharacterized protein; Belongs to the RNase T2 family. (218 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
ZC3H12BUncharacterized protein. (333 aa)
LAS1LLAS1 like, ribosome biogenesis factor. (722 aa)
ANGEL1Angel homolog 1. (680 aa)
REXO1RNA exonuclease 1 homolog. (1218 aa)
RRP36Ribosomal RNA processing 36. (257 aa)
MGME1Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (342 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (463 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (383 aa)
PLSCR1Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (313 aa)
CPSF2Cleavage and polyadenylation specificity factor subunit 2. (782 aa)
XRN15'-3' exoribonuclease 1. (1707 aa)
MEIOBMeiosis specific with OB-fold. (472 aa)
TBL3Transducin beta like 3. (808 aa)
BMS1BMS1 ribosome biogenesis factor. (1283 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa)
B4GALNT4Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1039 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
SETMARSET domain and mariner transposase fusion gene. (684 aa)
DBR1Debranching RNA lariats 1. (544 aa)
XPAXPA, DNA damage recognition and repair factor. (226 aa)
UTP23UTP23 small subunit processome component. (249 aa)
NCBP1Nuclear cap binding protein subunit 1. (790 aa)
G3BP1G3BP stress granule assembly factor 1. (466 aa)
ENSCSAP00000007055Uncharacterized protein. (251 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (940 aa)
EXOSC3Exosome component 3. (275 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (279 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1920 aa)
OGG18-oxoguanine DNA glycosylase. (405 aa)
PGBD5PiggyBac transposable element derived 5. (524 aa)
NUDT16Nudix hydrolase 16. (195 aa)
ASTE1Asteroid homolog 1. (679 aa)
PIWIL3Piwi like RNA-mediated gene silencing 3; Belongs to the argonaute family. (870 aa)
TATDN1TatD DNase domain containing 1. (281 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
TATDN2Uncharacterized protein. (761 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa)
DNASE1Deoxyribonuclease; Belongs to the DNase I family. (288 aa)
APTXAprataxin. (356 aa)
TSEN2tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (466 aa)
PLD4Phospholipase D family member 4. (515 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (904 aa)
EXO1Exonuclease 1. (845 aa)
ELAC2ElaC ribonuclease Z 2. (826 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (572 aa)
DXODecapping exoribonuclease. (396 aa)
RCL1RNA terminal phosphate cyclase like 1. (373 aa)
EXOSC4Exosome component 4. (245 aa)
BOP1Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (745 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa)
CPSF1Cleavage and polyadenylation specific factor 1. (1442 aa)
PLD6Phospholipase D family member 6. (249 aa)
C11orf80Chromosome 11 open reading frame 80. (524 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (557 aa)
RPP21Ribonuclease P/MRP subunit p21. (154 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
PARNPoly(A)-specific ribonuclease. (639 aa)
ZNRD1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
MARF1Meiosis regulator and mRNA stability factor 1. (1742 aa)
ABT1Activator of basal transcription 1. (276 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (907 aa)
DDX1DEAD-box helicase 1. (740 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (358 aa)
MRPL44Mitochondrial ribosomal protein L44. (280 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
ERI2ERI1 exoribonuclease family member 2. (691 aa)
REXO5RNA exonuclease 5. (772 aa)
RPP40Ribonuclease P/MRP subunit p40. (363 aa)
YBEYYbeY metalloendoribonuclease. (147 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (631 aa)
KRI1KRI1 homolog. (590 aa)
HAUS7HAUS augmin like complex subunit 7. (387 aa)
RNASEH1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
ENDOUEndonuclease, poly(U) specific. (391 aa)
RPP30Ribonuclease P/MRP subunit p30. (268 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (929 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (918 aa)
TRIRTelomerase RNA component interacting RNase. (176 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa)
TUT1PAP-associated domain-containing protein. (784 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (251 aa)
ATAD5ATPase family AAA domain containing 5. (1838 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (346 aa)
CPSF7Cleavage and polyadenylation specific factor 7. (462 aa)
SLFN12Schlafen family member 12. (580 aa)
SLFN12LSchlafen family member 12 like. (616 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
RAD51CRAD51 paralog C. (367 aa)
ANKLE1Ankyrin repeat and LEM domain containing 1. (615 aa)
NME1Nucleoside diphosphate kinase. (152 aa)
C12orf10Chromosome 12 open reading frame 10. (380 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (953 aa)
N4BP1NEDD4 binding protein 1. (810 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
TTC38Tetratricopeptide repeat domain 38. (475 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1202 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
DCLRE1ADNA cross-link repair 1A. (1040 aa)
POP4Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (218 aa)
USB1U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family. (265 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2376 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (555 aa)
CPSF4LCleavage and polyadenylation specific factor 4 like. (180 aa)
LRRC27Leucine rich repeat containing 27. (529 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
CPSF6Cleavage and polyadenylation specific factor 6. (588 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (540 aa)
NOB1RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (412 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
EDC4Enhancer of mRNA decapping 4. (1401 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ZGRF1Zinc finger GRF-type containing 1. (2109 aa)
PLD3Phospholipase D family member 3. (490 aa)
EXOSC9Exosome component 9. (439 aa)
PCF11PCF11 cleavage and polyadenylation factor subunit. (1555 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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