STRINGSTRING
EMC3 EMC3 VCP VCP HYOU1 HYOU1 STT3A STT3A SRPRA SRPRA NPLOC4 NPLOC4 MLEC MLEC P4HB P4HB EMC10 EMC10 ABCB9 ABCB9 KRTCAP2 KRTCAP2 ALG14 ALG14 PIGK PIGK FAF1 FAF1 MAP3K6 MAP3K6 DDOST DDOST EMC1 EMC1 ORMDL3 ORMDL3 EMC6 EMC6 LOC103230436 LOC103230436 PIGC PIGC ENSCSAP00000017859 ENSCSAP00000017859 OSTC OSTC RNF139 RNF139 STT3B STT3B B2M B2M TAPBP TAPBP OST4 OST4 PDIA3 PDIA3 TAP1 TAP1 FAF2 FAF2 GPAA1 GPAA1 UBXN7 UBXN7 SEC61A1 SEC61A1 PIGP PIGP GET1 GET1 ENSCSAP00000004214 ENSCSAP00000004214 SYVN1 SYVN1 MMGT1 MMGT1 FAM8A1 FAM8A1 NBAS NBAS PIGS PIGS SPTLC1 SPTLC1 EMC4 EMC4 EMC7 EMC7 PRKCSH PRKCSH UBXN1 UBXN1 ERN2 ERN2 GANAB GANAB GET3 GET3 CALR CALR INSIG1 INSIG1 TMEM258 TMEM258 SREBF2 SREBF2 EXT2 EXT2 HSD17B12 HSD17B12 RPN2 RPN2 DPM2 DPM2 PIGT PIGT RP9 RP9 PIGA PIGA SPTSSA SPTSSA AUP1 AUP1 SEC61G SEC61G TRAF2 TRAF2 EMC9 EMC9 DAD1 DAD1 TUSC3 TUSC3 SELENOS SELENOS MAP3K5 MAP3K5 FAM167A FAM167A UGT3A2 UGT3A2 UGT3A1 UGT3A1 SEC11A SEC11A RNF125 RNF125 RHBDD2 RHBDD2 SEC11C SEC11C C16orf74 C16orf74 EMC8 EMC8 SPCS3 SPCS3 ZW10 ZW10 ORMDL2 ORMDL2 ENSCSAP00000001596 ENSCSAP00000001596 AMFR AMFR OS9 OS9 RYR1 RYR1 ERN1 ERN1 SPCS2 SPCS2 ELOVL6 ELOVL6 SDF2L1 SDF2L1 CAMLG CAMLG SPCS1 SPCS1 HSPA5 HSPA5 PIGH PIGH SEC61A2 SEC61A2 MZB1 MZB1 HM13 HM13 PIGQ PIGQ SPTSSB SPTSSB PIGU PIGU SPTLC3 SPTLC3 SPTLC2 SPTLC2 EMC2 EMC2 UFD1 UFD1 SEL1L SEL1L RINT1 RINT1 DERL3 DERL3 SEC61B SEC61B MAGT1 MAGT1 SRPRB SRPRB DERL1 DERL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EMC3ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
STT3ASTT3 oligosaccharyltransferase complex catalytic subunit A. (705 aa)
SRPRASRP receptor subunit alpha. (638 aa)
NPLOC4NPL4 homolog, ubiquitin recognition factor. (608 aa)
MLECMalectin. (294 aa)
P4HBProtein disulfide-isomerase. (510 aa)
EMC10ER membrane protein complex subunit 10. (262 aa)
ABCB9ATP binding cassette subfamily B member 9. (766 aa)
KRTCAP2Keratinocyte associated protein 2. (162 aa)
ALG14ALG14 UDP-N-acetylglucosaminyltransferase subunit. (216 aa)
PIGKGPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (395 aa)
FAF1Fas associated factor 1. (649 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1300 aa)
DDOSTDolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (439 aa)
EMC1ER membrane protein complex subunit 1. (995 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
EMC6ER membrane protein complex subunit 6. (110 aa)
LOC103230436Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
PIGCPhosphatidylinositol glycan anchor biosynthesis class C. (297 aa)
ENSCSAP00000017859Uncharacterized protein. (336 aa)
OSTCOligosaccharyltransferase complex subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All s [...] (149 aa)
RNF139Ring finger protein 139. (664 aa)
STT3BSTT3 oligosaccharyltransferase complex catalytic subunit B. (825 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
TAPBPTAP binding protein. (504 aa)
OST4Oligosaccharyltransferase complex subunit 4, non-catalytic. (37 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (798 aa)
FAF2Fas associated factor family member 2. (445 aa)
GPAA1Glycosylphosphatidylinositol anchor attachment 1. (621 aa)
UBXN7UBX domain protein 7. (521 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (423 aa)
PIGPPhosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. (134 aa)
GET1Guided entry of tail-anchored proteins factor 1. (174 aa)
ENSCSAP00000004214Uncharacterized protein; Belongs to the universal ribosomal protein uS8 family. (348 aa)
SYVN1Synoviolin 1. (617 aa)
MMGT1Uncharacterized protein. (266 aa)
FAM8A1Family with sequence similarity 8 member A1. (413 aa)
NBASNeuroblastoma amplified sequence. (2375 aa)
PIGSPhosphatidylinositol glycan anchor biosynthesis class S. (547 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
EMC4ER membrane protein complex subunit 4; Belongs to the EMC4 family. (183 aa)
EMC7ER membrane protein complex subunit 7. (271 aa)
PRKCSHProtein kinase C substrate 80K-H. (535 aa)
UBXN1UBX domain protein 1. (297 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (929 aa)
GANABGlucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family. (910 aa)
GET3ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (348 aa)
CALRCalreticulin. (417 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
TMEM258Transmembrane protein 258. (79 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1144 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (751 aa)
HSD17B12Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
RPN2Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (631 aa)
DPM2Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (84 aa)
PIGTPhosphatidylinositol glycan anchor biosynthesis class T. (578 aa)
RP9RP9 pre-mRNA splicing factor. (221 aa)
PIGAPhosphatidylinositol glycan anchor biosynthesis class A. (484 aa)
SPTSSASerine palmitoyltransferase small subunit A. (71 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (410 aa)
SEC61GSEC61 translocon gamma subunit. (68 aa)
TRAF2TNF receptor-associated factor. (449 aa)
EMC9ER membrane protein complex subunit 9. (208 aa)
DAD1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (113 aa)
TUSC3Tumor suppressor candidate 3. (347 aa)
SELENOSSelenoprotein S. (188 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1219 aa)
FAM167AFamily with sequence similarity 167 member A. (214 aa)
UGT3A2UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (523 aa)
UGT3A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (523 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (153 aa)
RNF125Ring finger protein 125. (232 aa)
RHBDD2Rhomboid domain containing 2. (364 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (192 aa)
C16orf74Chromosome 16 open reading frame 74. (74 aa)
EMC8ER membrane protein complex subunit 8. (210 aa)
SPCS3Signal peptidase complex subunit 3. (180 aa)
ZW10Zw10 kinetochore protein. (781 aa)
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
ENSCSAP00000001596Uncharacterized protein. (292 aa)
AMFRAutocrine motility factor receptor. (643 aa)
OS9OS9 endoplasmic reticulum lectin. (668 aa)
RYR1Ryanodine receptor 1. (4303 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
SPCS2Signal peptidase complex subunit 2. (232 aa)
ELOVL6Elongation of very long chain fatty acids protein. (192 aa)
SDF2L1Stromal cell derived factor 2 like 1. (221 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (270 aa)
SPCS1Signal peptidase complex subunit 1. (169 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
PIGHPhosphatidylinositol glycan anchor biosynthesis class H. (184 aa)
SEC61A2SEC61 translocon alpha 2 subunit. (423 aa)
MZB1Marginal zone B and B1 cell specific protein. (188 aa)
HM13Histocompatibility minor 13. (376 aa)
PIGQPhosphatidylinositol glycan anchor biosynthesis class Q. (581 aa)
SPTSSBSerine palmitoyltransferase small subunit B. (114 aa)
PIGUPhosphatidylinositol glycan anchor biosynthesis class U. (435 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (552 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (325 aa)
EMC2ER membrane protein complex subunit 2. (297 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (794 aa)
RINT1RAD50 interactor 1. (792 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (235 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
MAGT1Magnesium transporter 1. (312 aa)
SRPRBSRP receptor subunit beta. (271 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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