node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHMP2A | HGS | ENSCSAP00000016440 | ENSCSAP00000015796 | Charged multivesicular body protein 2A. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.947 |
CHMP2A | PDCD6IP | ENSCSAP00000016440 | ENSCSAP00000005596 | Charged multivesicular body protein 2A. | BRO1 domain-containing protein. | 0.660 |
CHMP2A | SNF8 | ENSCSAP00000016440 | ENSCSAP00000015550 | Charged multivesicular body protein 2A. | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | 0.941 |
CHMP2A | STAM | ENSCSAP00000016440 | ENSCSAP00000008819 | Charged multivesicular body protein 2A. | Signal transducing adaptor molecule. | 0.614 |
CHMP2A | TSG101 | ENSCSAP00000016440 | ENSCSAP00000001374 | Charged multivesicular body protein 2A. | Tumor susceptibility 101. | 0.900 |
CHMP2A | VPS4A | ENSCSAP00000016440 | ENSCSAP00000000479 | Charged multivesicular body protein 2A. | Uncharacterized protein; Belongs to the AAA ATPase family. | 0.960 |
ENSCSAP00000010642 | PDCD6IP | ENSCSAP00000010642 | ENSCSAP00000005596 | Uncharacterized protein. | BRO1 domain-containing protein. | 0.756 |
ENSCSAP00000010642 | SDC1 | ENSCSAP00000010642 | ENSCSAP00000004340 | Uncharacterized protein. | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.522 |
ENSCSAP00000010642 | SDC4 | ENSCSAP00000010642 | ENSCSAP00000010494 | Uncharacterized protein. | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.763 |
HGS | CHMP2A | ENSCSAP00000015796 | ENSCSAP00000016440 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Charged multivesicular body protein 2A. | 0.947 |
HGS | PDCD6IP | ENSCSAP00000015796 | ENSCSAP00000005596 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | BRO1 domain-containing protein. | 0.670 |
HGS | SNF8 | ENSCSAP00000015796 | ENSCSAP00000015550 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | 0.897 |
HGS | STAM | ENSCSAP00000015796 | ENSCSAP00000008819 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Signal transducing adaptor molecule. | 0.999 |
HGS | TSG101 | ENSCSAP00000015796 | ENSCSAP00000001374 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Tumor susceptibility 101. | 0.994 |
HGS | VPS4A | ENSCSAP00000015796 | ENSCSAP00000000479 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Uncharacterized protein; Belongs to the AAA ATPase family. | 0.597 |
PDCD6IP | CHMP2A | ENSCSAP00000005596 | ENSCSAP00000016440 | BRO1 domain-containing protein. | Charged multivesicular body protein 2A. | 0.660 |
PDCD6IP | ENSCSAP00000010642 | ENSCSAP00000005596 | ENSCSAP00000010642 | BRO1 domain-containing protein. | Uncharacterized protein. | 0.756 |
PDCD6IP | HGS | ENSCSAP00000005596 | ENSCSAP00000015796 | BRO1 domain-containing protein. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.670 |
PDCD6IP | SDC1 | ENSCSAP00000005596 | ENSCSAP00000004340 | BRO1 domain-containing protein. | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.491 |
PDCD6IP | SDCBP | ENSCSAP00000005596 | ENSCSAP00000018195 | BRO1 domain-containing protein. | Uncharacterized protein. | 0.756 |