STRINGSTRING
UPK3B UPK3B BRCA2 BRCA2 PMS2 PMS2 FANCI FANCI PAXX PAXX ERCC8 ERCC8 MSH3 MSH3 XRCC4 XRCC4 PRKDC PRKDC ASCC3 ASCC3 MLH1 MLH1 MSH6 MSH6 MSH2 MSH2 DCLRE1C DCLRE1C PMS1 PMS1 MLH3 MLH3 ATP23 ATP23 PHF21A PHF21A RAD23B RAD23B XPA XPA RCOR1 RCOR1 FANCD2 FANCD2 ASCC2 ASCC2 XPC XPC XRCC5 XRCC5 TP53BP1 TP53BP1 ZSWIM7 ZSWIM7 ASCC1 ASCC1 NHEJ1 NHEJ1 ERCC4 ERCC4 CETN2 CETN2 SWSAP1 SWSAP1 PALB2 PALB2 XRCC6 XRCC6 LIG4 LIG4 KDM1A KDM1A POLD1 POLD1 ATM ATM ERCC1 ERCC1 BRCA1 BRCA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UPK3BUroplakin 3B. (276 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (862 aa)
FANCIFA complementation group I. (1199 aa)
PAXXPAXX non-homologous end joining factor. (204 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1125 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4131 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2202 aa)
MLH1MutL homolog 1. (756 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
DCLRE1CDNA cross-link repair 1C. (639 aa)
PMS1PMS1 homolog 1, mismatch repair system component. (931 aa)
MLH3MutL homolog 3. (1237 aa)
ATP23Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (246 aa)
PHF21APHD finger protein 21A. (599 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
XPAXPA, DNA damage recognition and repair factor. (226 aa)
RCOR1REST corepressor 1. (352 aa)
FANCD2Uncharacterized protein. (1458 aa)
ASCC2Activating signal cointegrator 1 complex subunit 2. (752 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (888 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
TP53BP1Tumor protein p53 binding protein 1. (1977 aa)
ZSWIM7Zinc finger SWIM-type containing 7. (140 aa)
ASCC1Activating signal cointegrator 1 complex subunit 1. (379 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
CETN2Centrin 2. (163 aa)
SWSAP1SWIM-type zinc finger 7 associated protein 1. (229 aa)
PALB2Partner and localizer of BRCA2. (1183 aa)
XRCC6X-ray repair cross complementing 6. (609 aa)
LIG4DNA ligase. (911 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (872 aa)
POLD1DNA polymerase. (1086 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
BRCA1Uncharacterized protein. (663 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.