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MACROH2A1 MACROH2A1 FOXC1 FOXC1 NDN NDN FOXC2 FOXC2 ENSCSAP00000017750 ENSCSAP00000017750 KDM1A KDM1A ZNF683 ZNF683 HDAC1 HDAC1 GADD45A GADD45A GTF2B GTF2B TRIM28 TRIM28 ZNF304 ZNF304 ENSCSAP00000016053 ENSCSAP00000016053 ZNF750 ZNF750 IRF3 IRF3 PCGF2 PCGF2 MED1 MED1 IKZF3 IKZF3 ZC3H4 ZC3H4 ERCC1 ERCC1 POU4F2 POU4F2 SETDB1 SETDB1 FOXO1 FOXO1 ENSCSAP00000013833 ENSCSAP00000013833 NIPBL NIPBL ISL1 ISL1 GLI2 GLI2 NRL NRL HDAC2 HDAC2 PCGF1 PCGF1 PRDM1 PRDM1 ATF2 ATF2 CHD7 CHD7 SMAD3 SMAD3 WDR13 WDR13 EGR1 EGR1 DHX9 DHX9 ZNF609 ZNF609 BMI1 BMI1 MAGED2 MAGED2 STAT1 STAT1 TRO TRO FOXO4 FOXO4 POLR2A POLR2A KLF4 KLF4 TP53 TP53 GTF2F1 GTF2F1 HNRNPU HNRNPU EHMT2 EHMT2 HSF1 HSF1 PRDM15 PRDM15 ERCC4 ERCC4 SIRT1 SIRT1 DNMT1 DNMT1 EZH2 EZH2 SOX10 SOX10 MECP2 MECP2 SUZ12 SUZ12 ATF4 ATF4 RBL2 RBL2 MYOD1 MYOD1 TAF10 TAF10 NUP98 NUP98 DDX5 DDX5 E2F4 E2F4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (368 aa)
FOXC1Forkhead box C1. (552 aa)
NDNNecdin, MAGE family member. (321 aa)
FOXC2Forkhead box C2. (501 aa)
ENSCSAP00000017750Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (872 aa)
ZNF683Zinc finger protein 683. (281 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
TRIM28Tripartite motif containing 28. (834 aa)
ZNF304Zinc finger protein 304. (659 aa)
ENSCSAP00000016053Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (497 aa)
ZNF750Zinc finger protein 750. (723 aa)
IRF3Interferon regulatory factor 3. (422 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
IKZF3IKAROS family zinc finger 3. (509 aa)
ZC3H4Zinc finger CCCH-type containing 4. (1257 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
POU4F2POU domain protein. (407 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1139 aa)
FOXO1Forkhead box O1. (655 aa)
ENSCSAP00000013833Uncharacterized protein. (132 aa)
NIPBLNipped-B protein. (2804 aa)
ISL1ISL LIM homeobox 1. (349 aa)
GLI2GLI family zinc finger 2. (1554 aa)
NRLNeural retina leucine zipper. (237 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
PRDM1PR/SET domain 1. (825 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
WDR13WD repeat domain 13. (564 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
DHX9DExH-box helicase 9. (1126 aa)
ZNF609Zinc finger protein 609. (1414 aa)
BMI1RING-type domain-containing protein. (449 aa)
MAGED2MAGE family member D2. (606 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
TROTrophinin. (1430 aa)
FOXO4Forkhead box O4. (505 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1971 aa)
KLF4Kruppel like factor 4. (479 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (438 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1197 aa)
HSF1Heat shock transcription factor 1. (529 aa)
PRDM15PR/SET domain 15. (1160 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
SIRT1Sirtuin 1. (743 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1616 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
SOX10SRY-box transcription factor 10. (236 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (479 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
ATF4Activating transcription factor 4. (351 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
NUP98Nucleoporin 98. (1800 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
E2F4E2F transcription factor 4. (418 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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