STRINGSTRING
SP6 SP6 FZD2 FZD2 FZD7 FZD7 CITED2 CITED2 SPRY1 SPRY1 NOG NOG DVL1 DVL1 AJAP1 AJAP1 ARHGEF19 ARHGEF19 WNT4 WNT4 GRHL3 GRHL3 TACSTD2 TACSTD2 ROR1 ROR1 CELSR2 CELSR2 CSF1 CSF1 WNT2B WNT2B VANGL1 VANGL1 JHY JHY NGFR NGFR HOXB7 HOXB7 VANGL2 VANGL2 PLEKHA4 PLEKHA4 SFRP2 SFRP2 TGFB1 TGFB1 NTN4 NTN4 SMURF1 SMURF1 APCDD1 APCDD1 PDGFA PDGFA ANKRD6 ANKRD6 MESP1 MESP1 GDNF GDNF DAB2 DAB2 CTNNB1 CTNNB1 AHI1 AHI1 FGF10 FGF10 WNT3A WNT3A SAPCD2 SAPCD2 RSPO3 RSPO3 MSX1 MSX1 FZD3 FZD3 BMP7 BMP7 CELSR3 CELSR3 CD34 CD34 SFRP1 SFRP1 BMP4 BMP4 SNAI2 SNAI2 ABL1 ABL1 HOXD11 HOXD11 DACT1 DACT1 DAAM1 DAAM1 HOXA11 HOXA11 SIX1 SIX1 SIX4 SIX4 SULF1 SULF1 DVL3 DVL3 BMP2 BMP2 GATA3 GATA3 SIX2 SIX2 PKHD1-2 PKHD1-2 PKHD1 PKHD1 MLLT3 MLLT3 BMPR1A BMPR1A SMO SMO PHB2 PHB2 WNT9B WNT9B WNT11 WNT11 SEC24B SEC24B SMURF2 SMURF2 FRS2 FRS2 SOX9 SOX9 CELSR1 CELSR1 LGR4 LGR4 WT1 WT1 NKD1 NKD1 HOXC11 HOXC11 FGF8 FGF8 PAX2 PAX2 MKS1 MKS1 SHH SHH PRICKLE1 PRICKLE1 AGT AGT DKK1 DKK1 ROR2 ROR2 STOX1 STOX1 GPC4 GPC4 WNT10A WNT10A DMRT3 DMRT3 TIAM1 TIAM1 WNT7A WNT7A FGF7 FGF7 RYK RYK CAV3 CAV3 TNFRSF11B TNFRSF11B WNT2 WNT2 BTBD7 BTBD7 MED12 MED12 PTK7 PTK7 RSPO2 RSPO2 TBX1 TBX1 SOX8 SOX8 CTHRC1 CTHRC1 AR AR FZD6 FZD6 HGF HGF DVL2 DVL2 PRICKLE2 PRICKLE2 RUNX2 RUNX2 FGF1 FGF1 MAGED1 MAGED1 WNT5A WNT5A SPEF1 SPEF1 GREM1 GREM1 AGTR2 AGTR2 FZD1 FZD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SP6Sp6 transcription factor. (376 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DVL1Dishevelled segment polarity protein 1. (574 aa)
AJAP1Adherens junctions associated protein 1. (409 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19. (809 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
GRHL3Grainyhead like transcription factor 3. (623 aa)
TACSTD2Tumor associated calcium signal transducer 2. (339 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1. (749 aa)
CELSR2Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2757 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (560 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (347 aa)
VANGL1Vang-like protein. (524 aa)
JHYJunctional cadherin complex regulator. (777 aa)
NGFRNerve growth factor receptor. (427 aa)
HOXB7Homeobox B7. (217 aa)
VANGL2Vang-like protein. (521 aa)
PLEKHA4Pleckstrin homology domain containing A4. (721 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NTN4Netrin 4. (628 aa)
SMURF1E3 ubiquitin-protein ligase. (728 aa)
APCDD1APC down-regulated 1. (514 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
ANKRD6Ankyrin repeat domain 6. (727 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
DAB2DAB adaptor protein 2. (770 aa)
CTNNB1Catenin beta 1. (781 aa)
AHI1Abelson helper integration site 1. (1202 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
SAPCD2Suppressor APC domain containing 2. (395 aa)
RSPO3R-spondin 3. (273 aa)
MSX1Msh homeobox 1. (303 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CELSR3Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family. (3317 aa)
CD34CD34 molecule. (385 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
ABL1Tyrosine-protein kinase. (1130 aa)
HOXD11Homeobox D11. (338 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (798 aa)
DAAM1Dishevelled associated activator of morphogenesis 1. (1078 aa)
HOXA11Homeobox A11. (310 aa)
SIX1SIX homeobox 1. (284 aa)
SIX4SIX homeobox 4. (780 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
GATA3GATA binding protein 3. (443 aa)
SIX2SIX homeobox 2. (290 aa)
PKHD1-2Uncharacterized protein. (139 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (2535 aa)
MLLT3MLLT3 super elongation complex subunit. (543 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
PHB2Prohibitin. (288 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1213 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (474 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
SOX9SRY-box transcription factor 9. (509 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3017 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
WT1WT1 transcription factor. (320 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (421 aa)
HOXC11Homeobox C11. (304 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PAX2Paired box 2. (261 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PRICKLE1Prickle planar cell polarity protein 1. (831 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2. (581 aa)
STOX1Storkhead box 1. (876 aa)
GPC4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1466 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
RYKReceptor like tyrosine kinase. (609 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
TNFRSF11BTNF receptor superfamily member 11b. (428 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
BTBD7BTB domain containing 7. (1125 aa)
MED12Mediator complex subunit 12. (2090 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
RSPO2R-spondin 2. (243 aa)
TBX1T-box transcription factor 1. (490 aa)
SOX8SRY-box transcription factor 8. (446 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
ARAndrogen receptor. (900 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
DVL2Dishevelled segment polarity protein 2. (733 aa)
PRICKLE2Prickle planar cell polarity protein 2. (844 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (450 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MAGED1MAGE family member D1. (778 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SPEF1Sperm flagellar 1. (236 aa)
GREM1Gremlin. (184 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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