STRINGSTRING
TP53 TP53 PAX6 PAX6 NF1 NF1 SPINT1 SPINT1 GATA2 GATA2 PTN PTN BTG2 BTG2 NR2E1 NR2E1 PROX1 PROX1 LIMS2 LIMS2 SLC16A2 SLC16A2 KIFAP3 KIFAP3 WNT5A WNT5A CTNNA1 CTNNA1 ENSCSAP00000019086 ENSCSAP00000019086 VAX1 VAX1 CEND1 CEND1 APPL2 APPL2 TGFB1 TGFB1 SIRT2 SIRT2 KDM2B KDM2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
PAX6Paired box 6. (436 aa)
NF1Neurofibromin 1. (2849 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (513 aa)
GATA2GATA binding protein 2. (397 aa)
PTNPleiotrophin. (168 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
PROX1Prospero homeobox 1. (737 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (341 aa)
SLC16A2Solute carrier family 16 member 2. (537 aa)
KIFAP3Kinesin associated protein 3. (794 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CTNNA1Catenin alpha 1. (906 aa)
ENSCSAP00000019086Uncharacterized protein. (141 aa)
VAX1Ventral anterior homeobox 1. (333 aa)
CEND1Cell cycle exit and neuronal differentiation 1. (152 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (664 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
KDM2BLysine demethylase 2B. (1348 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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