STRINGSTRING
OTP OTP EGF EGF WDR62 WDR62 GLI1 GLI1 CX3CL1 CX3CL1 PAX6 PAX6 PITX3 PITX3 MDK MDK LHX1 LHX1 CIP2A CIP2A SHH SHH SMARCD3 SMARCD3 SOX10 SOX10 DLL4 DLL4 ID4 ID4 ENSCSAP00000005586 ENSCSAP00000005586 ELL3 ELL3 SMO SMO DISC1 DISC1 LHX2 LHX2 ASPM ASPM HIF1A HIF1A GPR37L1 GPR37L1 TOX TOX LYN LYN ZNF335 ZNF335 NR2E1 NR2E1 LRP2 LRP2 GLI3 GLI3 PROX1 PROX1 NOTCH1 NOTCH1 FZD3 FZD3 WNT3A WNT3A CTNNB1 CTNNB1 DCT DCT VEGFC VEGFC DRD2 DRD2 LHX5 LHX5 CDON CDON NES NES DMRTA2 DMRTA2 KDM1A KDM1A DISP3 DISP3 GJC2 GJC2 CX3CR1 CX3CR1 ASCL1 ASCL1 RASSF10 RASSF10 FOXG1 FOXG1 FZD9 FZD9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OTPOrthopedia homeobox. (325 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
WDR62WD repeat domain 62. (1514 aa)
GLI1GLI family zinc finger 1. (1106 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (402 aa)
PAX6Paired box 6. (436 aa)
PITX3Homeobox protein. (302 aa)
MDKUncharacterized protein. (159 aa)
LHX1LIM homeobox 1. (406 aa)
CIP2ACell proliferation regulating inhibitor of protein phosphatase 2A. (910 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (470 aa)
SOX10SRY-box transcription factor 10. (236 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
ENSCSAP00000005586Uncharacterized protein. (163 aa)
ELL3Elongation factor for RNA polymerase II 3. (399 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
DISC1DISC1 scaffold protein. (639 aa)
LHX2LIM homeobox 2. (406 aa)
ASPMAbnormal spindle microtubule assembly. (2794 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
GPR37L1G protein-coupled receptor 37 like 1. (481 aa)
TOXThymocyte selection associated high mobility group box. (487 aa)
LYNTyrosine-protein kinase. (512 aa)
ZNF335Zinc finger protein 335. (1346 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
LRP2LDL receptor related protein 2. (3861 aa)
GLI3GLI family zinc finger 3. (1459 aa)
PROX1Prospero homeobox 1. (737 aa)
NOTCH1Notch receptor 1. (2555 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CTNNB1Catenin beta 1. (781 aa)
DCTDopachrome tautomerase. (519 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
LHX5LIM homeobox 5. (402 aa)
CDONCell adhesion associated, oncogene regulated. (1287 aa)
NESNestin; Belongs to the intermediate filament family. (1619 aa)
DMRTA2DMRT like family A2. (538 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (872 aa)
DISP3Dispatched RND transporter family member 3. (1392 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (441 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (239 aa)
RASSF10Ras association domain family member 10. (508 aa)
FOXG1Forkhead box G1. (490 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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