STRINGSTRING
ARHGEF18 ARHGEF18 NCOR1 NCOR1 PPP1CA PPP1CA STRAP STRAP LTBP3 LTBP3 ITGB5 ITGB5 MEN1 MEN1 UBE2D1 UBE2D1 CCNQ CCNQ CCNT1 CCNT1 MAPK3 MAPK3 EP300 EP300 MTMR4 MTMR4 SP1 SP1 KXD1 KXD1 UBA52 UBA52 IRX3 IRX3 IRX5 IRX5 IRX6 IRX6 USP15 USP15 SMURF2 SMURF2 PARD6A PARD6A ITGB3 ITGB3 E2F4 E2F4 LTBP4 LTBP4 WWTR1 WWTR1 ENSCSAP00000019055 ENSCSAP00000019055 ENSCSAP00000018574 ENSCSAP00000018574 ENSCSAP00000018444 ENSCSAP00000018444 JUNB JUNB TGIF2LX TGIF2LX ENSCSAP00000017765 ENSCSAP00000017765 ENSCSAP00000017750 ENSCSAP00000017750 TFDP3 TFDP3 ENSCSAP00000017575 ENSCSAP00000017575 PRKCZ PRKCZ SKI SKI HDAC1 HDAC1 YBX1 YBX1 ZFYVE9 ZFYVE9 UBE2M UBE2M TRIM33 TRIM33 ENSCSAP00000016224 ENSCSAP00000016224 ENSCSAP00000016053 ENSCSAP00000016053 UBC UBC NCOR2 NCOR2 CBL CBL F11R F11R PPP1CC PPP1CC PPP1R15A PPP1R15A MEIS3 MEIS3 TGFB1 TGFB1 ATP1B4 ATP1B4 USP9Y USP9Y NEDD4L NEDD4L SMAD4 SMAD4 SMAD7 SMAD7 SMAD2 SMAD2 SERPINE1 SERPINE1 CDK8 CDK8 RNF165 RNF165 ENSCSAP00000013833 ENSCSAP00000013833 SMURF1 SMURF1 TGIF1 TGIF1 LDLRAD4 LDLRAD4 TFDP1 TFDP1 IRX4 IRX4 IRX2 IRX2 IRX1 IRX1 FURIN FURIN CCNT2 CCNT2 PARP1 PARP1 TGFB2 TGFB2 ITGB6 ITGB6 PMEPA1 PMEPA1 RHOA RHOA CCNC CCNC XPO1 XPO1 PPM1A PPM1A RPS27A RPS27A USP9X USP9X CDK9 CDK9 MAPK1 MAPK1 ITGB8 ITGB8 SMAD3 SMAD3 E2F5 E2F5 ITGA8 ITGA8 COL1A2 COL1A2 SKIL SKIL ITGAV ITGAV LTBP2 LTBP2 STUB1 STUB1 STAT1 STAT1 PCSK4 PCSK4 RNF111 RNF111 TGFB3 TGFB3 MKX MKX SNW1 SNW1 BAMBI BAMBI LTBP1 LTBP1 ITGB1 ITGB1 PARD3 PARD3 TFDP2 TFDP2 TGFBR1 TGFBR1 PPP1CB PPP1CB FKBP1A FKBP1A FBN1 FBN1 CCNK CCNK PARD3B PARD3B MYC MYC TGIF2 TGIF2 CDKN2B CDKN2B TGFBR2 TGFBR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGEF18Uncharacterized protein. (1172 aa)
NCOR1Nuclear receptor corepressor 1. (2445 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
STRAPSerine/threonine kinase receptor associated protein. (350 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1298 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
MEN1Menin 1. (610 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
CCNQCyclin Q; Belongs to the cyclin family. (248 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (728 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
EP300E1A binding protein p300. (2416 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
SP1Sp1 transcription factor. (786 aa)
KXD1KxDL motif containing 1. (176 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
IRX3Iroquois homeobox 3. (416 aa)
IRX5Iroquois homeobox 5. (410 aa)
IRX6Iroquois homeobox 6. (446 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (474 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
E2F4E2F transcription factor 4. (418 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1557 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
ENSCSAP00000019055Transcription factor. (409 aa)
ENSCSAP00000018574Ubiquitin-like domain-containing protein. (81 aa)
ENSCSAP00000018444Ubiquitin-like domain-containing protein. (127 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
TGIF2LXTGFB induced factor homeobox 2 like X-linked. (249 aa)
ENSCSAP00000017765Ubiquitin-like domain-containing protein. (155 aa)
ENSCSAP00000017750Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
TFDP3Transcription factor. (405 aa)
ENSCSAP00000017575Ubiquitin-like domain-containing protein. (156 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (488 aa)
SKISKI proto-oncogene. (728 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
YBX1Y-box binding protein 1. (255 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1380 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
TRIM33Tripartite motif containing 33. (1127 aa)
ENSCSAP00000016224Myosin_tail_1 domain-containing protein. (1099 aa)
ENSCSAP00000016053Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (497 aa)
UBCUncharacterized protein. (228 aa)
NCOR2Nuclear receptor corepressor 2. (2521 aa)
CBLCbl proto-oncogene. (907 aa)
F11RF11 receptor. (323 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (719 aa)
MEIS3Meis homeobox 3. (375 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (356 aa)
USP9YUbiquitin specific peptidase 9 Y-linked; Belongs to the peptidase C19 family. (2237 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (993 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
RNF165Ring finger protein 165. (326 aa)
ENSCSAP00000013833Uncharacterized protein. (132 aa)
SMURF1E3 ubiquitin-protein ligase. (728 aa)
TGIF1TGFB induced factor homeobox 1. (272 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (269 aa)
TFDP1Transcription factor. (410 aa)
IRX4Iroquois homeobox 4. (515 aa)
IRX2Iroquois homeobox 2. (378 aa)
IRX1Iroquois homeobox 1. (418 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (663 aa)
PARP1Poly(ADP-ribose) polymerase 1. (709 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (287 aa)
RHOARas homolog family member A. (193 aa)
CCNCCyclin C; Belongs to the cyclin family. (283 aa)
XPO1Exportin 1. (1071 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (488 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
E2F5E2F transcription factor 5. (351 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
COL1A2Collagen type I alpha 2 chain. (1274 aa)
SKILSKI like proto-oncogene. (684 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1824 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (681 aa)
RNF111Ring finger protein 111. (985 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MKXMohawk homeobox. (272 aa)
SNW1SNW domain containing 1. (536 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1724 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PARD3Par-3 family cell polarity regulator. (1218 aa)
TFDP2Transcription factor. (404 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
FKBP1APeptidylprolyl isomerase. (145 aa)
FBN1Fibrillin 1. (2666 aa)
CCNKCyclin K; Belongs to the cyclin family. (407 aa)
PARD3BPar-3 family cell polarity regulator beta. (1037 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (137 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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