STRINGSTRING
GRB2 GRB2 BCAR1 BCAR1 STAT6 STAT6 PDGFRA PDGFRA PIK3R2 PIK3R2 PDGFB PDGFB NEDD9 NEDD9 KRAS KRAS NCK1 NCK1 HRAS HRAS PIK3CB PIK3CB PDGFRB PDGFRB STAT1 STAT1 SOS1 SOS1 FNDC3B FNDC3B PIK3CA PIK3CA CRKL CRKL SRC SRC PLCG1 PLCG1 CRK CRK RASA1 RASA1 RAPGEF1 RAPGEF1 CASS4 CASS4 PIK3R1 PIK3R1 EFS EFS NCK2 NCK2 PDGFA PDGFA FNDC3A FNDC3A STAT3 STAT3 STAT5A STAT5A STAT5B STAT5B GRB7 GRB7 PTPN11 PTPN11 CSDE1 CSDE1 NRAS NRAS ERAS ERAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRB2Growth factor receptor bound protein 2. (217 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (870 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PIK3R2Uncharacterized protein. (629 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NCK1Cytoplasmic protein. (377 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
SRCTyrosine-protein kinase. (633 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1264 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EFSEmbryonal Fyn-associated substrate. (527 aa)
NCK2Cytoplasmic protein. (382 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5ASignal transducer and activator of transcription. (798 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
GRB7Growth factor receptor bound protein 7. (532 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ERASES cell expressed Ras. (233 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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