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THBS1 THBS1 COL5A3 COL5A3 COL4A4 COL4A4 BCAR1 BCAR1 SPP1 SPP1 GRB2 GRB2 STAT6 STAT6 PDGFRA PDGFRA VWA2 VWA2 PIK3R2 PIK3R2 COL6A3 COL6A3 COL2A1 COL2A1 PDGFB PDGFB COL4A3 COL4A3 COL6A2 COL6A2 COL6A1 COL6A1 PDGFRB PDGFRB PTPN12 PTPN12 PCSK4 PCSK4 STAT1 STAT1 PLG PLG SOS1 SOS1 COL5A2 COL5A2 COL3A1 COL3A1 FNDC3B FNDC3B PIK3CA PIK3CA CRKL CRKL COL9A1 COL9A1 SRC SRC PLCG1 PLCG1 CRK CRK RASA1 RASA1 RAPGEF1 RAPGEF1 PLAT PLAT THBS4 THBS4 CASS4 CASS4 COL5A1 COL5A1 PIK3R1 PIK3R1 EFS EFS COL9A3 COL9A3 FURIN FURIN NCK2 NCK2 COL4A2 COL4A2 COL4A1 COL4A1 PDGFA PDGFA FNDC3A FNDC3A PDGFC PDGFC STAT3 STAT3 STAT5A STAT5A STAT5B STAT5B PDGFD PDGFD GRB7 GRB7 PTPN11 PTPN11 THBS3 THBS3 CSDE1 CSDE1 NRAS NRAS COL9A2 COL9A2 ERAS ERAS NEDD9 NEDD9 KRAS KRAS COL4A5 COL4A5 ENSCSAP00000006425 ENSCSAP00000006425 COL6A5 COL6A5 COL6A6 COL6A6 NCK1 NCK1 HRAS HRAS PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THBS1Thrombospondin 1. (1170 aa)
COL5A3Collagen type V alpha 3 chain. (1749 aa)
COL4A4Collagen type IV alpha 4 chain. (1692 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (870 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
VWA2Von Willebrand factor A domain containing 2. (757 aa)
PIK3R2Uncharacterized protein. (629 aa)
COL6A3Collagen type VI alpha 3 chain. (3175 aa)
COL2A1Collagen type II alpha 1 chain. (1488 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
COL6A2Collagen type VI alpha 2 chain. (1019 aa)
COL6A1Uncharacterized protein. (1003 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (780 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (681 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
COL3A1Collagen type III alpha 1 chain. (878 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
SRCTyrosine-protein kinase. (633 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1264 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
THBS4Thrombospondin 4. (870 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
COL5A1Collagen type V alpha 1 chain. (1641 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EFSEmbryonal Fyn-associated substrate. (527 aa)
COL9A3Uncharacterized protein. (684 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
NCK2Cytoplasmic protein. (382 aa)
COL4A2Collagen type IV alpha 2 chain. (1696 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5ASignal transducer and activator of transcription. (798 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
PDGFDPlatelet derived growth factor D. (332 aa)
GRB7Growth factor receptor bound protein 7. (532 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
THBS3Thrombospondin 3. (947 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
COL9A2Collagen type IX alpha 2 chain. (689 aa)
ERASES cell expressed Ras. (233 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
COL4A5Collagen type IV alpha 5 chain. (882 aa)
ENSCSAP00000006425Uncharacterized protein. (2238 aa)
COL6A5Collagen type VI alpha 5 chain. (2618 aa)
COL6A6Collagen type VI alpha 6 chain. (2262 aa)
NCK1Cytoplasmic protein. (377 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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