STRINGSTRING
PPP2CA PPP2CA ELK1 ELK1 AP2M1 AP2M1 MAP2K5 MAP2K5 CRKL CRKL MAP2K1 MAP2K1 EGR1 EGR1 RPS6KA3 RPS6KA3 ATF2 ATF2 MAPK15 MAPK15 BRAF BRAF FOSL1 FOSL1 MAPK7 MAPK7 KRAS KRAS ID4 ID4 NTRK2 NTRK2 EGR2 EGR2 SHC3 SHC3 ENSCSAP00000003372 ENSCSAP00000003372 KIDINS220 KIDINS220 ID2 ID2 DNM2 DNM2 SHC2 SHC2 YWHAB YWHAB MAPKAPK3 MAPKAPK3 CDK5 CDK5 ENSCSAP00000010255 ENSCSAP00000010255 LYL1 LYL1 DNAL4 DNAL4 CDK5R1 CDK5R1 AP2B1 AP2B1 MAPK3 MAPK3 ATF1 ATF1 CLTC CLTC EP300 EP300 FNBP4 FNBP4 PIK3R2 PIK3R2 REST REST NAB2 NAB2 TPH1 TPH1 MAPK12 MAPK12 MAPK11 MAPK11 GRB2 GRB2 RRAD RRAD FRS2 FRS2 DUSP6 DUSP6 DNM1 DNM1 CRK CRK SH3GL2 SH3GL2 ENSCSAP00000005580 ENSCSAP00000005580 CREB1 CREB1 TRIB1 TRIB1 MAPK14 MAPK14 MAPK13 MAPK13 CHD4 CHD4 AP2A2 AP2A2 SHC4 SHC4 ADORA2A ADORA2A CLTA CLTA MAP2K2 MAP2K2 PPP4R4 PPP4R4 HRAS HRAS PIK3CB PIK3CB RPS6KA5 RPS6KA5 PPP2R5D PPP2R5D MEF2C MEF2C ADCYAP1R1 ADCYAP1R1 RAPGEF1 RAPGEF1 MAPKAPK2 MAPKAPK2 ENSCSAP00000011134 ENSCSAP00000011134 RHOA RHOA RALA RALA EGR4 EGR4 LOC103243620 LOC103243620 PPP2CB PPP2CB DUSP4 DUSP4 PIK3R1 PIK3R1 EGR3 EGR3 RALB RALB SGK1 SGK1 MEF2A MEF2A SH3GL3 SH3GL3 IRS2 IRS2 PPP4R1 PPP4R1 ENSCSAP00000013641 ENSCSAP00000013641 RIT2 RIT2 RELCH RELCH DUSP3 DUSP3 STAT3 STAT3 ENSCSAP00000014866 ENSCSAP00000014866 PPP2R1B PPP2R1B ENSCSAP00000015592 ENSCSAP00000015592 AP2A1 AP2A1 VRK3 VRK3 NTRK1 NTRK1 MEF2D MEF2D RIT1 RIT1 PPP2R1A PPP2R1A SHC1 SHC1 CSDE1 CSDE1 NRAS NRAS RAP1A RAP1A F3 F3 RPS6KA1 RPS6KA1 ID3 ID3 NGF NGF JUND JUND ARC ARC CDK5R2 CDK5R2 JUNB JUNB ASCL1 ASCL1 ASCL2 ASCL2 VGF VGF SRF SRF DNM3 DNM3 TCF12 TCF12 FOS FOS ENSCSAP00000008334 ENSCSAP00000008334 RPS6KA2 RPS6KA2 NAB1 NAB1 SOS1 SOS1 ERAS ERAS NKPD1 NKPD1 ID1 ID1 PIK3CA PIK3CA PLCG1 PLCG1 DUSP7 DUSP7 SRC SRC MAPK1 MAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ELK1Uncharacterized protein. (296 aa)
AP2M1Adaptor related protein complex 2 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (251 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MAPK15Mitogen-activated protein kinase. (593 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
NTRK2Neurotrophic receptor tyrosine kinase 2. (477 aa)
EGR2Early growth response 2. (476 aa)
SHC3SHC adaptor protein 3. (598 aa)
ENSCSAP00000003372Uncharacterized protein. (478 aa)
KIDINS220Kinase D interacting substrate 220. (1771 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
SHC2Uncharacterized protein. (590 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
MAPKAPK3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (382 aa)
CDK5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (224 aa)
ENSCSAP00000010255Protein kinase domain-containing protein. (310 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
DNAL4Dynein light chain. (105 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
AP2B1AP complex subunit beta. (951 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ATF1Activating transcription factor 1. (270 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1495 aa)
EP300E1A binding protein p300. (2416 aa)
FNBP4Formin binding protein 4. (1015 aa)
PIK3R2Uncharacterized protein. (629 aa)
RESTRE1 silencing transcription factor. (1096 aa)
NAB2NGFI-A binding protein 2. (442 aa)
TPH1Tryptophan hydroxylase 1. (343 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (775 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (317 aa)
ENSCSAP00000005580ETS domain-containing protein. (412 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CHD4Uncharacterized protein. (1914 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (939 aa)
SHC4SHC adaptor protein 4. (630 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
CLTAClathrin light chain A. (218 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (872 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RPS6KA5Ribosomal protein S6 kinase. (776 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
MEF2CMyocyte enhancer factor 2C. (446 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (496 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1264 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ENSCSAP00000011134Uncharacterized protein. (910 aa)
RHOARas homolog family member A. (193 aa)
RALARAS like proto-oncogene A. (206 aa)
EGR4Early growth response 4. (588 aa)
LOC103243620WRNPLPNID domain-containing protein. (925 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGR3Early growth response 3. (387 aa)
RALBRAS like proto-oncogene B. (206 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
MEF2AMyocyte enhancer factor 2A. (503 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (347 aa)
IRS2Insulin receptor substrate 2. (906 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (933 aa)
ENSCSAP00000013641GLUCAGON domain-containing protein. (322 aa)
RIT2Ras like without CAAX 2. (149 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ENSCSAP00000014866Uncharacterized protein. (177 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (599 aa)
ENSCSAP00000015592Adaptin_N domain-containing protein. (132 aa)
AP2A1Alpha_adaptinC2 domain-containing protein. (817 aa)
VRK3VRK serine/threonine kinase 3. (482 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
RIT1Ras like without CAAX 1. (233 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
SHC1SHC adaptor protein 1. (474 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
F3Coagulation factor III, tissue factor. (245 aa)
RPS6KA1Ribosomal protein S6 kinase. (735 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (241 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (348 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (239 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
VGFVGF nerve growth factor inducible. (615 aa)
SRFSerum response factor. (508 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
TCF12Transcription factor 12. (682 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ENSCSAP00000008334Uncharacterized protein. (72 aa)
RPS6KA2Ribosomal protein S6 kinase. (730 aa)
NAB1NGFI-A binding protein 1. (488 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ERASES cell expressed Ras. (233 aa)
NKPD1NTPase KAP family P-loop domain containing 1. (608 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
SRCTyrosine-protein kinase. (633 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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