STRINGSTRING
HRAS HRAS BCAR1 BCAR1 TENM4 TENM4 AKT2 AKT2 ITGB3 ITGB3 ELMO3 ELMO3 PAK1 PAK1 PRKCA PRKCA DOCK1 DOCK1 CDH5 CDH5 MAPK11 MAPK11 MAPK12 MAPK12 KDR KDR SPHK1 SPHK1 PRR5 PRR5 PIK3R2 PIK3R2 NCKAP1L NCKAP1L HSH2D HSH2D ENSCSAP00000002108 ENSCSAP00000002108 CTNND1 CTNND1 LPXN LPXN PRKACA PRKACA CYFIP1 CYFIP1 PRKCB PRKCB NOS3 NOS3 VEGFB VEGFB ROCK2 ROCK2 NEDD9 NEDD9 ITPR2 ITPR2 KRAS KRAS NCF4 NCF4 FLT4 FLT4 PAK2 PAK2 PAK3 PAK3 AAMP AAMP VAV1 VAV1 AKT3 AKT3 PTK2 PTK2 ITPR3 ITPR3 AKT1 AKT1 BRK1 BRK1 MAPK14 MAPK14 MAPK13 MAPK13 TENM2 TENM2 ENSCSAP00000006456 ENSCSAP00000006456 HSP90AA1 HSP90AA1 NRP2 NRP2 SHF SHF ABI2 ABI2 SHD SHD CYFIP2 CYFIP2 SHB SHB MLST8 MLST8 NCK1 NCK1 CAV1 CAV1 ITPR1 ITPR1 PIK3CB PIK3CB NRP1 NRP1 ARVCF ARVCF ABI1 ABI1 VEGFA VEGFA PGF PGF ITGAV ITGAV NCKAP1 NCKAP1 NCF2 NCF2 FNDC3B FNDC3B TRIB3 TRIB3 PIK3CA PIK3CA PRKCD PRKCD SHC2 SHC2 CTNNA1 CTNNA1 MAPKAP1 MAPKAP1 SRC SRC PLCG1 PLCG1 CRK CRK ENSCSAP00000010255 ENSCSAP00000010255 MAPKAPK3 MAPKAPK3 ELMO2 ELMO2 RASA1 RASA1 MAPKAPK2 MAPKAPK2 VEGFD VEGFD ELMO1 ELMO1 RHOA RHOA CASS4 CASS4 WASF1 WASF1 VAV2 VAV2 FYN FYN PIK3R1 PIK3R1 PTK2B PTK2B EFS EFS STX7 STX7 CTNNB1 CTNNB1 RICTOR RICTOR NCK2 NCK2 ROCK1 ROCK1 ENSCSAP00000013696 ENSCSAP00000013696 FNDC3A FNDC3A FLT1 FLT1 WASF3 WASF3 CYBB CYBB HSPB1 HSPB1 NCF1 NCF1 PDPK1 PDPK1 TENM1 TENM1 AXL AXL VEGFC VEGFC CYBA CYBA TENM3 TENM3 JUP JUP BAIAP2 BAIAP2 PXN PXN SH2D2A SH2D2A SHE SHE THEM4 THEM4 CSDE1 CSDE1 NRAS NRAS AHCYL1 AHCYL1 VAV3 VAV3 PRKACB PRKACB STX12 STX12 WASF2 WASF2 CDC42 CDC42 ACTL8 ACTL8 SZRD1 SZRD1 MTOR MTOR PRKCZ PRKCZ ACTRT2 ACTRT2 ENSCSAP00000017376 ENSCSAP00000017376 RNF222 RNF222 ACTL7A ACTL7A ACTL7B ACTL7B LOC103240948 LOC103240948 ACTRT1 ACTRT1 PRKACG PRKACG ACTL9 ACTL9 ERAS ERAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HRASHRas proto-oncogene, GTPase. (189 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (870 aa)
TENM4Teneurin transmembrane protein 4. (2605 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
ELMO3Engulfment and cell motility 3. (720 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1330 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
SPHK1Sphingosine kinase 1. (472 aa)
PRR5Proline rich 5. (379 aa)
PIK3R2Uncharacterized protein. (629 aa)
NCKAP1LNCK associated protein 1 like. (907 aa)
HSH2DHematopoietic SH2 domain containing. (352 aa)
ENSCSAP00000002108WD_REPEATS_REGION domain-containing protein. (434 aa)
CTNND1Catenin delta 1. (962 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (354 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
NOS3Nitric oxide synthase 3. (867 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NCF4Neutrophil cytosolic factor 4. (294 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
AAMPWD_REPEATS_REGION domain-containing protein. (435 aa)
VAV1Vav guanine nucleotide exchange factor 1. (719 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1038 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BRK1Uncharacterized protein. (75 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
TENM2Teneurin transmembrane protein 2. (1419 aa)
ENSCSAP00000006456Teneurin N-terminal domain-containing protein. (172 aa)
HSP90AA1HATPase_c domain-containing protein. (387 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (901 aa)
SHFSrc homology 2 domain containing F. (286 aa)
ABI2Abl interactor 2. (523 aa)
SHDSrc homology 2 domain containing transforming protein D. (340 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
NCK1Cytoplasmic protein. (377 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2758 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ARVCFARVCF delta catenin family member. (935 aa)
ABI1Abl interactor 1. (508 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
NCKAP1NCK associated protein 1. (1128 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
TRIB3Tribbles pseudokinase 3. (358 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
SHC2Uncharacterized protein. (590 aa)
CTNNA1Catenin alpha 1. (906 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
SRCTyrosine-protein kinase. (633 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
ENSCSAP00000010255Protein kinase domain-containing protein. (310 aa)
MAPKAPK3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (382 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
RHOARas homolog family member A. (193 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
WASF1WASP family member 1. (559 aa)
VAV2Vav guanine nucleotide exchange factor 2. (896 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
EFSEmbryonal Fyn-associated substrate. (527 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
CTNNB1Catenin beta 1. (781 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1679 aa)
NCK2Cytoplasmic protein. (382 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ENSCSAP00000013696Uncharacterized protein; Belongs to the actin family. (223 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
WASF3WASP family member 3. (502 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (143 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
TENM1Teneurin transmembrane protein 1. (2558 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
TENM3Teneurin transmembrane protein 3. (2427 aa)
JUPJunction plakoglobin. (745 aa)
BAIAP2BAI1 associated protein 2. (595 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (591 aa)
SH2D2ASH2 domain containing 2A. (389 aa)
SHESrc homology 2 domain containing E. (495 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
VAV3Vav guanine nucleotide exchange factor 3. (782 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
WASF2WASP family member 2. (498 aa)
CDC42Cell division cycle 42. (191 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
SZRD1SUZ domain-containing protein. (152 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (488 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (377 aa)
ENSCSAP00000017376Uncharacterized protein. (75 aa)
RNF222Ring finger protein 222. (220 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
LOC103240948Uncharacterized protein. (375 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (375 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
ACTL9Actin like 9; Belongs to the actin family. (416 aa)
ERASES cell expressed Ras. (233 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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