STRINGSTRING
ADAM17 ADAM17 CNTN1 CNTN1 CUL1 CUL1 DNER DNER HDAC7 HDAC7 DTX4 DTX4 HDAC4 HDAC4 ENSCSAP00000018444 ENSCSAP00000018444 EP300 EP300 UBA52 UBA52 NEURL1 NEURL1 HDAC10 HDAC10 PSENEN PSENEN ARRB1 ARRB1 RBX1 RBX1 ENSCSAP00000017765 ENSCSAP00000017765 ENSCSAP00000017750 ENSCSAP00000017750 ENSCSAP00000017575 ENSCSAP00000017575 HES4 HES4 MIB2 MIB2 HES5 HES5 HDAC1 HDAC1 HEYL HEYL ENSCSAP00000016053 ENSCSAP00000016053 UBC UBC NCOR2 NCOR2 DTX1 DTX1 NCSTN NCSTN KAT2A KAT2A MAML2 MAML2 FBXW7 FBXW7 LRBA LRBA HDAC5 HDAC5 DTX2 DTX2 APH1A APH1A CDK8 CDK8 NBEA NBEA MIB1 MIB1 RBPJ RBPJ PSEN2 PSEN2 HEY2 HEY2 NOTCH1 NOTCH1 HDAC2 HDAC2 TBL1X TBL1X CCNC CCNC RPS27A RPS27A HIF1A HIF1A JAG1 JAG1 TLE3 TLE3 SKP1 SKP1 ENSCSAP00000009708 ENSCSAP00000009708 ENSCSAP00000009705 ENSCSAP00000009705 HDAC9 HDAC9 HEY1 HEY1 HDAC6 HDAC6 ARRB2 ARRB2 TBL1XR1 TBL1XR1 PSEN1 PSEN1 NUMB NUMB HDAC3 HDAC3 APH1B APH1B ITCH ITCH ADAM10 ADAM10 DLL1 DLL1 SNW1 SNW1 TLE2 TLE2 HDAC8 HDAC8 DLK1 DLK1 MYC MYC KAT2B KAT2B CREBBP CREBBP NEURL1B NEURL1B JAG2 JAG2 HDAC11 HDAC11 HES1 HES1 NCOR1 NCOR1 MAML1 MAML1 TLE4 TLE4 TLE1 TLE1 DLL4 DLL4 MAMLD1 MAMLD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADAM17ADAM metallopeptidase domain 17. (824 aa)
CNTN1Contactin 1. (1018 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
DNERDelta/notch like EGF repeat containing. (590 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (954 aa)
DTX4Deltex E3 ubiquitin ligase 4. (619 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1088 aa)
ENSCSAP00000018444Ubiquitin-like domain-containing protein. (127 aa)
EP300E1A binding protein p300. (2416 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
HDAC10Histone deacetylase 10. (671 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
ARRB1Arrestin beta 1. (418 aa)
RBX1Ring-box 1. (108 aa)
ENSCSAP00000017765Ubiquitin-like domain-containing protein. (155 aa)
ENSCSAP00000017750Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
ENSCSAP00000017575Ubiquitin-like domain-containing protein. (156 aa)
HES4Hes family bHLH transcription factor 4. (221 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (955 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
ENSCSAP00000016053Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (497 aa)
UBCUncharacterized protein. (228 aa)
NCOR2Nuclear receptor corepressor 2. (2521 aa)
DTX1Deltex E3 ubiquitin ligase 1. (624 aa)
NCSTNNicastrin. (709 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
MAML2Mastermind like transcriptional coactivator 2. (923 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
LRBALPS responsive beige-like anchor protein. (2113 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1155 aa)
DTX2Deltex E3 ubiquitin ligase 2. (622 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
NBEAUncharacterized protein. (752 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (357 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
NOTCH1Notch receptor 1. (2555 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
TBL1XTransducin beta like 1 X-linked. (572 aa)
CCNCCyclin C; Belongs to the cyclin family. (283 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
TLE3TLE family member 3, transcriptional corepressor. (769 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
ENSCSAP00000009708Hist_deacetyl domain-containing protein. (156 aa)
ENSCSAP00000009705Hist_deacetyl domain-containing protein. (114 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (780 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
HDAC6Histone deacetylase 6. (1215 aa)
ARRB2Arrestin beta 2. (409 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
PSEN1Presenilin 1. (467 aa)
NUMBNUMB endocytic adaptor protein. (652 aa)
HDAC3Hist_deacetyl domain-containing protein. (266 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
SNW1SNW domain containing 1. (536 aa)
TLE2TLE family member 2, transcriptional corepressor. (750 aa)
HDAC8Histone deacetylase 8. (364 aa)
DLK1Delta like non-canonical Notch ligand 1. (310 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
KAT2BLysine acetyltransferase 2B. (675 aa)
CREBBPCREB binding protein. (2417 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (555 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1245 aa)
HDAC11Histone deacetylase 11. (347 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
NCOR1Nuclear receptor corepressor 1. (2445 aa)
MAML1Mastermind like transcriptional coactivator 1. (790 aa)
TLE4TLE family member 4, transcriptional corepressor. (773 aa)
TLE1TLE family member 1, transcriptional corepressor. (770 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
MAMLD1Mastermind like domain containing 1. (810 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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