STRINGSTRING
KLB KLB IGF1R IGF1R IRS2 IRS2 KL KL PIK3C3 PIK3C3 FLT3 FLT3 FGF9 FGF9 PDPK1 PDPK1 GAB1 GAB1 IGF1 IGF1 FLT3LG FLT3LG PTPN11 PTPN11 THEM4 THEM4 NRAS NRAS IRS4 IRS4 ERAS ERAS PIK3CA PIK3CA LOC103227720 LOC103227720 GAB4 GAB4 FGFR1 FGFR1 FGFR3 FGFR3 PIK3R1 PIK3R1 FGF17 FGF17 FGF10 FGF10 FGF20 FGF20 FGF2 FGF2 AKT2 AKT2 GAB2 GAB2 FRS2 FRS2 FGF5 FGF5 FGFR2 FGFR2 PDE3B PDE3B GRB2 GRB2 PIK3R2 PIK3R2 FGF8 FGF8 TRIB2 TRIB2 KRAS KRAS FGFR4 FGFR4 FGF12 FGF12 FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 FGF18 FGF18 IGF2 IGF2 PIK3R4 PIK3R4 FGF7 FGF7 FGF16 FGF16 HRAS HRAS FGF6 FGF6 FGF23 FGF23 PIK3CB PIK3CB SPEM2 SPEM2 SPEM1 SPEM1 SOS1 SOS1 FGF1 FGF1 FGF22 FGF22 TRIB3 TRIB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLBKlotho beta. (907 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
IRS2Insulin receptor substrate 2. (906 aa)
KLKlotho. (1010 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
IGF1Insulin like growth factor 1. (159 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (288 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
IRS4Insulin receptor substrate 4. (1251 aa)
ERASES cell expressed Ras. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC103227720TIR domain-containing protein. (1032 aa)
GAB4GRB2 associated binding protein family member 4. (638 aa)
FGFR1Fibroblast growth factor receptor. (830 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (333 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
PDE3BPhosphodiesterase. (1117 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (629 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TRIB2Tribbles pseudokinase 2. (284 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FGFR4Fibroblast growth factor receptor. (806 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (142 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
IGF2Insulin like growth factor 2. (236 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SPEM2SPEM family member 2. (505 aa)
SPEM1Spermatid maturation 1. (309 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
TRIB3Tribbles pseudokinase 3. (358 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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