STRINGSTRING
CAMK2A CAMK2A ITPR1 ITPR1 GNB5 GNB5 GNG7 GNG7 PDE6A PDE6A FZD6 FZD6 GNG13 GNG13 GNG10 GNG10 GNGT1 GNGT1 GNG11 GNG11 WNT5A WNT5A GNB4 GNB4 PLCB1 PLCB1 TCF7 TCF7 MAP3K20 MAP3K20 ENSCSAP00000010823 ENSCSAP00000010823 WDR92 WDR92 PDE6B PDE6B PPP3R1 PPP3R1 GNG2 GNG2 ERAS ERAS ENSCSAP00000018787 ENSCSAP00000018787 FZD2 FZD2 FZD5 FZD5 ENSCSAP00000017690 ENSCSAP00000017690 GNB1 GNB1 AGO4 AGO4 AGO1 AGO1 AGO3 AGO3 GNG12 GNG12 GNAT2 GNAT2 MOV10 MOV10 PDE6G PDE6G GNGT2 GNGT2 GNG8 GNG8 FZD4 FZD4 NFATC1 NFATC1 GNB2 GNB2 MAP3K7 MAP3K7 CTNNB1 CTNNB1 TCF7L1 TCF7L1 FZD3 FZD3 WNT11 WNT11 LEF1 LEF1 PPP3CA PPP3CA PRKCA PRKCA NFAT5 NFAT5 PRKG2 PRKG2 ENSCSAP00000001444 ENSCSAP00000001444 GNAO1 GNAO1 TNRC6B TNRC6B PDE6C PDE6C GNG3 GNG3 PLCB3 PLCB3 PRKG1 PRKG1 PLCB2 PLCB2 NLK NLK ITPR2 ITPR2 KRAS KRAS PDE6H PDE6H PPP3CB PPP3CB AGO2 AGO2 ITPR3 ITPR3 GNG4 GNG4 GNB3 GNB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2758 aa)
GNB5G protein subunit beta 5. (353 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PDE6APhosphodiesterase. (860 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GNB4G protein subunit beta 4. (340 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
TCF7Transcription factor 7. (387 aa)
MAP3K20Protein kinase domain-containing protein. (292 aa)
ENSCSAP00000010823Protein kinase domain-containing protein. (169 aa)
WDR92WD repeat domain 92. (357 aa)
PDE6BPhosphodiesterase. (856 aa)
PPP3R1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
ERASES cell expressed Ras. (233 aa)
ENSCSAP00000018787Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
ENSCSAP00000017690Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNB1G protein subunit beta 1. (340 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNAT2G protein subunit alpha transducin 2. (357 aa)
MOV10Mov10 RISC complex RNA helicase. (1003 aa)
PDE6GPhosphodiesterase 6G. (87 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
NFATC1Nuclear factor of activated T cells 1. (929 aa)
GNB2G protein subunit beta 2. (340 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CTNNB1Catenin beta 1. (781 aa)
TCF7L1Transcription factor 7 like 1. (442 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
NFAT5Nuclear factor of activated T cells 5. (1548 aa)
PRKG2cGMP-dependent protein kinase. (675 aa)
ENSCSAP00000001444HMG box domain-containing protein. (377 aa)
GNAO1G protein subunit alpha o1. (354 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1773 aa)
PDE6CPhosphodiesterase. (858 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
PRKG1Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (471 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
NLKMitogen-activated protein kinase. (376 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PDE6HPhosphodiesterase 6H. (83 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (904 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNB3G protein subunit beta 3. (340 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.