STRINGSTRING
SRI SRI CACNG5 CACNG5 KCNK6 KCNK6 RYR1 RYR1 SCN4A SCN4A ENSCSAP00000000163 ENSCSAP00000000163 ATP2B1 ATP2B1 ENSCSAP00000001481 ENSCSAP00000001481 KCNK18 KCNK18 SCN1B SCN1B FXYD3 FXYD3 FXYD1 FXYD1 FXYD7 FXYD7 FXYD5 FXYD5 STIM1 STIM1 CACNG4 CACNG4 HIPK2 HIPK2 FKBP1B FKBP1B CAMK2G CAMK2G KCNK3 KCNK3 NKX2-5 NKX2-5 KCNQ1 KCNQ1 KCNK9 KCNK9 ITPR3 ITPR3 RYR2 RYR2 KAT2B KAT2B KCNIP1 KCNIP1 ATP2B2 ATP2B2 ASPHD2 ASPHD2 KCNK1 KCNK1 KCNJ11 KCNJ11 KCNJ4 KCNJ4 KCNA5 KCNA5 PLN PLN KCNE4 KCNE4 KCNE1 KCNE1 KCNE2 KCNE2 KCNE5 KCNE5 ENSCSAP00000017596 ENSCSAP00000017596 KCNJ2 KCNJ2 KCNJ12 KCNJ12 SLN SLN KCNE3 KCNE3 RANGRF RANGRF NPR2 NPR2 KCND2 KCND2 ITPR1 ITPR1 FXYD4 FXYD4 KCNK5 KCNK5 KCNK17 KCNK17 KCNK16 KCNK16 ENSCSAP00000007254 ENSCSAP00000007254 ATP1B1 ATP1B1 ATP1B3 ATP1B3 TRPC1 TRPC1 CACNA1C CACNA1C ATP1B2 ATP1B2 KCNK13 KCNK13 WWTR1 WWTR1 CAMK2A CAMK2A KCNK10 KCNK10 FGF11 FGF11 MME MME CACNA2D1 CACNA2D1 SLC8A1 SLC8A1 AKAP9 AKAP9 CACNB2 CACNB2 SLC8A3 SLC8A3 KCND1 KCND1 ATP2A3 ATP2A3 KCNK12 KCNK12 CACNA2D2 CACNA2D2 KCNK15 KCNK15 ASPH ASPH ATP2B4 ATP2B4 PHEX PHEX SCN5A SCN5A SCN10A SCN10A SCN11A SCN11A SCN7A SCN7A SCN9A SCN9A SCN1A SCN1A SCN2A SCN2A SCN3A SCN3A KCNK2 KCNK2 CAMK2B CAMK2B MAST4 MAST4 ENSCSAP00000011977 ENSCSAP00000011977 KCNIP4 KCNIP4 STIM2 STIM2 GATA4 GATA4 CORIN CORIN ENSCSAP00000013420 ENSCSAP00000013420 FAHD2A FAHD2A KCNIP3 KCNIP3 FGF14 FGF14 ORAI2 ORAI2 ATP1A3 ATP1A3 DMPK DMPK SLC8A2 SLC8A2 KCNJ14 KCNJ14 CACNB1 CACNB1 ORAI1 ORAI1 NOS1 NOS1 TBX5 TBX5 SCN3B SCN3B ATP2A2 ATP2A2 MMEL1 MMEL1 NPPA NPPA NPPB NPPB MAST2 MAST2 AHCYL1 AHCYL1 KCND3 KCND3 HIPK1 HIPK1 CASQ2 CASQ2 ATP1A1 ATP1A1 TNNI3 TNNI3 NPR1 NPR1 CACNG6 CACNG6 CACNG8 CACNG8 CACNG7 CACNG7 FXYD2 FXYD2 FXYD6 FXYD6 SCN4B SCN4B SCN2B SCN2B CASQ1 CASQ1 ATP1A4 ATP1A4 ATP1A2 ATP1A2 CLIC2 CLIC2 MAST1 MAST1 NPPC NPPC ATP2A1 ATP2A1 KCNH2 KCNH2 RYR3 RYR3 ATP2B3 ATP2B3 KCNK4 KCNK4 FGF13 FGF13 ITPR2 ITPR2 KCNK7 KCNK7 ABCC9 ABCC9 ASPHD1 ASPHD1 SCN8A SCN8A ORAI3 ORAI3 KCNIP2 KCNIP2 MAST3 MAST3 ENSCSAP00000001494 ENSCSAP00000001494 ENSCSAP00000001489 ENSCSAP00000001489
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRISorcin. (183 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (278 aa)
KCNK6Potassium channel subfamily K member. (326 aa)
RYR1Ryanodine receptor 1. (4303 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1836 aa)
ENSCSAP00000000163Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (489 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1176 aa)
ENSCSAP00000001481Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (532 aa)
KCNK18Potassium two pore domain channel subfamily K member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (383 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (218 aa)
FXYD3FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (87 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
FXYD7FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (80 aa)
FXYD5FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (180 aa)
STIM1Stromal interaction molecule 1. (684 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (588 aa)
KCNK3Potassium channel subfamily K member. (394 aa)
NKX2-5NK2 homeobox 5. (324 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (518 aa)
KCNK9Potassium channel subfamily K member. (374 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
RYR2Ryanodine receptor 2. (4906 aa)
KAT2BLysine acetyltransferase 2B. (675 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (214 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1199 aa)
ASPHD2Aspartate beta-hydroxylase domain containing 2. (369 aa)
KCNK1Potassium channel subfamily K member. (336 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (445 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (170 aa)
KCNE1Uncharacterized protein. (146 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
ENSCSAP00000017596Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
KCNJ12Uncharacterized protein. (433 aa)
SLNSarcolipin. (31 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
NPR2Guanylate cyclase. (1047 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (389 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2758 aa)
FXYD4FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (89 aa)
KCNK5Potassium two pore domain channel subfamily K member 5; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (499 aa)
KCNK17Potassium channel subfamily K member. (332 aa)
KCNK16Potassium two pore domain channel subfamily K member 16; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (308 aa)
ENSCSAP00000007254FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (95 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (265 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (793 aa)
CACNA1CCalcium voltage-gated channel subunit alpha1 C. (1898 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
KCNK13Potassium two pore domain channel subfamily K member 13; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (408 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
KCNK10Potassium two pore domain channel subfamily K member 10; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (539 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
MMEMembrane metalloendopeptidase. (678 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (962 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (632 aa)
AKAP9A-kinase anchoring protein 9. (3922 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (612 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
KCND1Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family. (647 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1038 aa)
KCNK12Potassium two pore domain channel subfamily K member 12; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (430 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1074 aa)
KCNK15Potassium two pore domain channel subfamily K member 15; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (330 aa)
ASPHAspartate beta-hydroxylase. (744 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1170 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (652 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1881 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1956 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1791 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1680 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1992 aa)
SCN1ASodium voltage-gated channel alpha subunit 1. (1359 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2052 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1701 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (411 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (628 aa)
MAST4Microtubule associated serine/threonine kinase family member 4. (2430 aa)
ENSCSAP00000011977Uncharacterized protein. (92 aa)
KCNIP4Potassium voltage-gated channel interacting protein 4. (188 aa)
STIM2Stromal interaction molecule 2. (832 aa)
GATA4GATA binding protein 4. (442 aa)
CORINCorin, serine peptidase. (1042 aa)
ENSCSAP00000013420FAA_hydrolase domain-containing protein. (185 aa)
FAHD2AFumarylacetoacetate hydrolase domain containing 2A. (314 aa)
KCNIP3Potassium voltage-gated channel interacting protein 3. (196 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (261 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1013 aa)
DMPKDM1 protein kinase. (629 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (436 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (643 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (303 aa)
NOS1Nitric oxide synthase 1. (768 aa)
TBX5T-box transcription factor 5. (518 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (997 aa)
MMEL1Membrane metalloendopeptidase like 1. (779 aa)
NPPANatriuretic peptide A. (153 aa)
NPPBNatriuretic peptide B. (134 aa)
MAST2Microtubule associated serine/threonine kinase 2. (1802 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
NPR1Guanylate cyclase. (1270 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (261 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (421 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
FXYD6FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (95 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
MAST1Microtubule associated serine/threonine kinase 1. (1570 aa)
NPPCNatriuretic peptide C. (126 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (994 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1160 aa)
RYR3Ryanodine receptor 3. (3921 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1173 aa)
KCNK4Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (419 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (242 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
KCNK7Potassium two pore domain channel subfamily K member 7; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (305 aa)
ABCC9ATP binding cassette subfamily C member 9. (1549 aa)
ASPHD1Aspartate beta-hydroxylase domain containing 1. (366 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
ORAI3ORAI calcium release-activated calcium modulator 3. (295 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (285 aa)
MAST3Microtubule associated serine/threonine kinase 3. (1139 aa)
ENSCSAP00000001494Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
ENSCSAP00000001489Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (567 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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