STRINGSTRING
MKNK2 MKNK2 FRS3 FRS3 FGF23 FGF23 HRAS HRAS FGF16 FGF16 FGF18 FGF18 FGF4 FGF4 BRAF BRAF KRAS KRAS MAPK3 MAPK3 FGF8 FGF8 UBA52 UBA52 GRB2 GRB2 FGF5 FGF5 FRS2 FRS2 FGF2 FGF2 ERAS ERAS ENSCSAP00000018444 ENSCSAP00000018444 SPRY2 SPRY2 ENSCSAP00000017765 ENSCSAP00000017765 ENSCSAP00000017575 ENSCSAP00000017575 MKNK1 MKNK1 NRAS NRAS CSDE1 CSDE1 SHC1 SHC1 UBC UBC PPP2R1A PPP2R1A PTPN11 PTPN11 CBL CBL GAB1 GAB1 FGF9 FGF9 FNDC3A FNDC3A FGF20 FGF20 FGF17 FGF17 PPP2CB PPP2CB PIK3R1 PIK3R1 FGFR3 FGFR3 GALNT3 GALNT3 RPS27A RPS27A PLCG1 PLCG1 SRC SRC MAPK1 MAPK1 PPP2CA PPP2CA PIK3CA PIK3CA FNDC3B FNDC3B FGF1 FGF1 SOS1 SOS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
ERASES cell expressed Ras. (233 aa)
ENSCSAP00000018444Ubiquitin-like domain-containing protein. (127 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
ENSCSAP00000017765Ubiquitin-like domain-containing protein. (155 aa)
ENSCSAP00000017575Ubiquitin-like domain-containing protein. (156 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (418 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CSDE1Cold shock domain containing E1. (844 aa)
SHC1SHC adaptor protein 1. (474 aa)
UBCUncharacterized protein. (228 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
CBLCbl proto-oncogene. (907 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (333 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
GALNT3Polypeptide N-acetylgalactosaminyltransferase. (633 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
SRCTyrosine-protein kinase. (633 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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